Navigation Links
Resistance to Anti-HIV Drugs in Uganda Developed Due to Drug Supply Problems

Some HIV-infected patients in Uganda who self-paid for their antiretroviral medications experienced interruptions in drug supply due to either financial// demands or supply logistical disruptions. These treatment interruptions led to the development of resistance to antiretroviral medications in patients.

These findings by a team led by researchers at the Infectious Diseases Institute at Makerere University, Kampala, and UCSF are reported in the April 22, 2007 issue of the journal "AIDS."

"We have found the concern is not about the occasional missed dose—most of the patients had near perfect adherence and full suppression of the virus— but about supply interruptions that led to longer multi-day treatment interruptions allowing resistance to develop," said study lead author Jessica Oyugi, MD, from the Infectious Diseases Institute at Makerere University, Kampala, Uganda.

The study followed just under 100 patients who self paid for generic fixed-dose antiretroviral formulations. Findings showed that medications were very effective at suppressing the virus, with full viral suppression in over 80 percent of people on treatment for 6 months. Resistance developed in people during treatment interruptions, and 90 percent of all missed doses were due to treatment interruptions as opposed to the occasional skipped dose. Further, almost 50 percent of the participants interrupted treatment due to financial difficulties. In addition, at one point during the study period, supply of one product was halted due to customs issues. A two-week nationwide shortage resulted that created gaps in treatment for some individuals taking that medication.

"In a context where the ability of poor people to adhere to medications regimens has been questioned, the issue is not so much about behavioral strategies to increase adherence, but about structural failures that interrupt access to treatment. Free access to treatment leads to better survival th an self-pay therapy because free treatment may be less susceptible to interruptions that lead to resistance" said study senior author David R. Bangsberg, MD, MPH, director of the UCSF Epidemiology and Prevention Interventions Center at San Francisco General Hospital.

The climate in Uganda has changed since the study took place between September 2002 and April 2004. At that time, most patients paid for antiretroviral therapy. Today, most HIV patients are receiving drugs supplied for free by either PEPFAR—the U.S. President’s Emergency Plan for AIDS Relief, a five-year, $15-billion, multifaceted approach to combating HIV/AIDS around the world—or The Global Fund to Fight AIDS, Tuberculosis and Malaria, which was created to dramatically increase resources to fight three of the world's most devastating diseases, and to direct those resources to areas of greatest need.

"Notwithstanding the current programs providing free antiretrovirals, these findings do highlight the need for strong logistics and drug supply management in any antiretroviral therapy program as well as continued monitoring of adherence. While our patients did a great job of taking their medications as directed when they were affordable and available, their overall adherence did wane a bit over the study period," said Oyugi.

Source-Eurekalert
MD/B
'"/>




Related medicine news :

1. Link between birth weight and Insulin Resistance
2. Easier Methods Required to Screen Insulin Resistance
3. Easier Methods Required to Screen Insulin Resistance
4. Insulin Resistance Linked To Difference In Gender
5. Adopting Easier Methods To Screen Insulin Resistance
6. Drug Resistance Questioned in Patients With Chronic Sinusitis
7. Understanding Insulin Resistance
8. Scientists Unveil Mechanism Behind Resistance to Severe Malaria
9. Junk Food Causes High Level Of Insulin Resistance In Children
10. Ways Of Tackling Antibiotic Resistance
11. Flu-Drugs Are Causing Resistance Across The World
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... N.J. (PRWEB) , ... June 27, 2016 , ... Quality ... sources, yet in many ways they remain in the eye of the beholder, according ... (EBO), a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... Orion, Clarkston, Michigan (PRWEB) , ... June 26, ... ... with respect to fertility once they have been diagnosed with endometriosis. These women ... intercourse but they also require a comprehensive approach that can help for preservation ...
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published ... unfamiliar with. The article goes on to state that individuals are now more comfortable ... less common operations such as calf and cheek reduction. The Los Angeles area medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg ... Legal Elite. The attorneys chosen by their peers for this recognition are considered among ... Greenberg Traurig Shareholders received special honors as members of this year’s Legal Elite Hall ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research and ... Market for Companion Diagnostic Tests" report to their offering. ... for Companion Diagnostics The World Market for ... personalized medicine diagnostics. Market analysis in the report includes the ... Market (In Vitro Diagnostic Kits) by Region (N. America, EU, ...
(Date:6/24/2016)... 2016   Pulmatrix, Inc ., (NASDAQ: ... drugs, announced today that it was added to the ... its comprehensive set of U.S. and global equity indexes ... important milestone for Pulmatrix," said Chief Executive Officer ... our progress in developing drugs for crucial unmet medical ...
(Date:6/24/2016)... , June 24, 2016  Arkis BioSciences, ... less invasive and more durable cerebrospinal fluid treatments, ... funding.  The Series-A funding is led by Innova ... Fund, and other private investors.  Arkis, new financing ... instrumentation and the market release of its in-licensed ...
Breaking Medicine Technology: