Navigation Links
Researchers have Identified the Gene that Spreads Skin Cancer

static melanoma, scientists have discovered large regions of chromosomal DNA that have been amplified or deleted. In such cases, it would be a daunting task to pinpoint the actual gene culprit among a large number of “bystander” gene abnormalities that may not be relevant to the cancer.

For example, scientists had previously shown that the entire short arm of Chromosome 6, referred to as 6p, is amplified in more than 35 percent of cells from melanoma tumors that had metastasized. But the 6p region is only rarely amplified in primary, non-spreading melanomas. There are hundreds of genes on 6p, making the task of narrowing down to a few candidate culprits nearly impossible. Chin had previously created transgenic mice in which melanoma could be induced by turning cancer genes on or off. When tumors from these mice were transplanted into normal mice lacking an immune system, the cancers grew and a few of them became metastatic. Genome scans of the metastatic tumors -- known as "escapers" -- revealed an amplified region on Chromosome 13 that was not present in the primary (non-metastatic) tumor cells. That region, presumably, reflected a genetic change that promoted metastasis.

Although it is located on Chromosome 13 in the mouse, the amplified region was similar to the amplified region on Chromosome 6 in human melanoma cells, but, fortunately, it contained only eight genes. Therefore it was possible to pinpoint the NEDD9 gene in the mouse tumors and verify that the same gene in humans, when overactive, drives metastasis of melanoma tumors.

"This is a demonstration of the principle, that the mouse has similar genomic changes that are important for cancer, and we can use the mouse model as a 'filter' to help us identify which gene is responsible for the cancer development and metastasis," said Chin, who is also an associate professor of dermatology at Harvard Medical School.

(Source: Newswis)
'"/>




Page: 1 2

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers have Identified the Gene that Spreads Skin Cancer

(Date:11/18/2014)... (HealthDay News) -- Until recently, insect-transmitted Chagas disease was found ... made its way to the United States over the past ... transmitted via the bite of the "kissing bug," which feeds ... new study suggests that common bedbugs might be carriers as ... transmit the parasite. Our next step is to determine whether ...
(Date:11/17/2014)... Los Angeles, CA (PRWEB) November 17, 2014 ... revealed that thousands of patients throughout the country are ... feeling better than ever before. This is because the ... hormone therapy to their already impressive collection of prescription ... , Those who have incorporated Diet Doc’s best ...
(Date:11/17/2014)... World Food Processing announced today that they will ... airing via RFD-TV 2nd QTR 2015. American Farmer airs ... World Food Processing is a sustainable solution for non-GMO ... provides a secure system, supplying non-GMO and organic products ... educate viewers about World Food Processing’s unparalleled capability to ...
(Date:11/17/2014)... Whitehouse Station, NJ (PRWEB) November 17, 2014 ... military families with their September “Dog Tag” Promotion. ... than $75,000 for Hope For The Warriors® in support ... For The Warriors® is a national nonprofit dedicated to ... and restoring hope for our service members and our ...
(Date:11/17/2014)... For the first time in medical ... from a single cell extracted from a 3-day-old embryo ... father’s family. Double-board certified expert Maher Abdallah, M.D. of ... then implanted only the healthy embryos that, in turn, ... In Vitro Fertilization has taken a giant step forward ...
Breaking Medicine News(10 mins):Health News:Bedbugs Could Be Potential New Source of Tropical Disease in U.S. 2Health News:Bedbugs Could Be Potential New Source of Tropical Disease in U.S. 3Health News:Best Anti-Aging Human Growth Hormone Therapy Safely and Naturally Restores Diet Doc Patients to More Youthful Levels 2Health News:Best Anti-Aging Human Growth Hormone Therapy Safely and Naturally Restores Diet Doc Patients to More Youthful Levels 3Health News:American Farmer to Feature World Food Processing in 2015 Series 2Health News:QuickChek Gives Big Support to Hope For The Warriors One Dollar at a Time 2Health News:IVF Specialist From American Reproductive Centers Performs World's First DNA Sequencing On Single Cell So Defected Genes Won't Be Passed To Future Generations 2
... Rising Medical Solutions, Inc.,(Rising), a leading medical-financial ... featured in Norman Scarborough,s recently published,entrepreneurship textbook, ... and previous editions, are utilized in business,schools ... providing tools and,encouragement to those students who ...
... Ancient acupuncture and modern myofascial pain therapy each focus ... treat pain, although they do it differently, says a ... two techniques. , Results of the study, published May ... suggest that people who want relief from chronic musculoskeletal ...
... in patient care by recognizing quality and,safety in ... The American Society,for Gastrointestinal Endoscopy (ASGE) announces the ... in endoscopy, in all settings,where it is practiced ... Program will recognize endoscopy units that follow the ...
... Group on Health, a national non-profit organization of ... and,dedication to promoting a healthy workplace and encouraging ... Sanofi-aventis U.S. was among 52 employers that received ... Leadership Summit sponsored,by the National Business Group on ...
... executive to lead BCBSIL,s sales and,marketing, CHICAGO, ... divisional senior vice president, Local and Consumer Markets, ... In his new role, Freer,will oversee small, mid-market, ... Illinois, as well as manage HMO Illinois. Freer ...
... RELEASE, 13 May 200] Scientists at the Swedish medical ... that a receptor called ALK7 plays important roles in ... the release of insulin from beta-cells in the pancreas. ... against diabetes and obesity. , We have shown ...
Cached Medicine News:Health News:Rising Medical Solutions and CEO Are Featured as a Case Study in the Effective Small Business Management, Ninth Edition Textbook 2Health News:Rising Medical Solutions and CEO Are Featured as a Case Study in the Effective Small Business Management, Ninth Edition Textbook 3Health News:Mayo Clinic study shows acupuncture and myofascial trigger therapy treat same pain areas 2Health News:ASGE Launches Endoscopy Unit Recognition Program 2Health News:ASGE Launches Endoscopy Unit Recognition Program 3Health News:ASGE Launches Endoscopy Unit Recognition Program 4Health News:Sanofi-aventis Named One of Best Employers for Healthy Lifestyles by National Business Group on Health 2Health News:Sanofi-aventis Named One of Best Employers for Healthy Lifestyles by National Business Group on Health 3Health News:Blue Cross and Blue Shield of Illinois Names New Vice President, Local and Consumer Markets 2Health News:Novel mechanisms controlling insulin release and fat deposition discovered 2
(Date:11/18/2014)... 2014  Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ) ... Monday, December 8, 2014 at 9:00 a.m. Eastern Time to ... th American Society of Hematology Annual Meeting and Exposition.  ... by dialing 877-443-5662 or access the webcast at www.isispharm.com ... time at the same address. ABOUT ISIS ...
(Date:11/18/2014)... 18, 2014  Renova Therapeutics, a biopharmaceutical company ... and other chronic diseases, announced that Daniel ... The company also completed its third round of ... board member brings decades of life science experience ... executive with more than 30 years of experience ...
(Date:11/17/2014)... STAAR Surgical Company (NASDAQ: STAA ... lenses and delivery systems for the eye, today announced ... Medical Technology & Diagnostics Forum in New ... Thursday, November 20 at 12:30 p.m. PT/3:30 p.m. ET. ... of the Company,s current business trends, financial results, and ...
Breaking Medicine Technology:Isis Pharmaceuticals to Host Webcast to Discuss ISIS-FXI Rx Data Presented at the ASH Annual Meeting 2Isis Pharmaceuticals to Host Webcast to Discuss ISIS-FXI Rx Data Presented at the ASH Annual Meeting 3Renova Therapeutics welcomes new board member, raises $7.52 million in Series C financing round 2Renova Therapeutics welcomes new board member, raises $7.52 million in Series C financing round 3STAAR Surgical To Present At The Canaccord Genuity 2014 Medical Technology & Diagnostics Forum 2
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: