Navigation Links
Researchers have Identified the Gene that Spreads Skin Cancer

Researchers have identified a novel gene that facilitates the spread of malignant melanoma, a life-threatening skin cancer, //using a technique they say can speed the discovery of hard-to-find cancer genes.

A team of scientists from Dana-Farber Cancer Institute, led by Lynda Chin, MD, report that the gene, NEDD9, is abnormally abundant in more than a third of melanomas that have metastasized, but not in primary melanomas that have not spread.

The protein made by the NEDD9 gene allows the cancer cells to migrate beyond the initial skin tumor, to invade surrounding tissues and ultimately to metastasize to distant organs. While the protein itself does not lend itself to targeting by cancer drugs, say the researchers, insights gained in this study suggest that disrupting genes and proteins associated with NEDD9 may be fruitful in halting spread of melanoma.

"This is clinically important," said Chin, "because primary skin melanoma doesn’t kill patients – metastases are the major problem. So understanding the events that drive metastasis may lead to identifying the most relevant targets for therapy, and potentially, for preventing metastasis."

More than 62,000 cases of melanoma will be diagnosed in the United States this year, according to American Cancer Society estimates, and about 7,900 people will die of the cancer.

Chin and her group at Dana-Farber use genome-scanning methods such as array-CGH (comparative genomic hybridization) to uncover structural abnormalities of the chromosomes of cancer cells. In one common form of abnormality, bits of DNA have been overcopied (amplified) or, conversely, have been lost (deleted), and these "copy number alterations" are key events in the development and progression of cancers.

If the alterations are confined to a very small part of the chromosome, it is relatively easy to identify the likely culprits involved in the cancer. But in some cancers, including meta static melanoma, scientists have discovered large regions of chromosomal DNA that have been amplified or deleted. In such cases, it would be a daunting task to pinpoint the actual gene culprit among a large number of “bystander” gene abnormalities that may not be relevant to the cancer.

For example, scientists had previously shown that the entire short arm of Chromosome 6, referred to as 6p, is amplified in more than 35 percent of cells from melanoma tumors that had metastasized. But the 6p region is only rarely amplified in primary, non-spreading melanomas. There are hundreds of genes on 6p, making the task of narrowing down to a few candidate culprits nearly impossible. Chin had previously created transgenic mice in which melanoma could be induced by turning cancer genes on or off. When tumors from these mice were transplanted into normal mice lacking an immune system, the cancers grew and a few of them became metastatic. Genome scans of the metastatic tumors -- known as "escapers" -- revealed an amplified region on Chromosome 13 that was not present in the primary (non-metastatic) tumor cells. That region, presumably, reflected a genetic change that promoted metastasis.

Although it is located on Chromosome 13 in the mouse, the amplified region was similar to the amplified region on Chromosome 6 in human melanoma cells, but, fortunately, it contained only eight genes. Therefore it was possible to pinpoint the NEDD9 gene in the mouse tumors and verify that the same gene in humans, when overactive, drives metastasis of melanoma tumors.

"This is a demonstration of the principle, that the mouse has similar genomic changes that are important for cancer, and we can use the mouse model as a 'filter' to help us identify which gene is responsible for the cancer development and metastasis," said Chin, who is also an associate professor of dermatology at Harvard Medical School.

(Source: Newswis)
'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of ... award to iHire in recognition of their exemplary accomplishments in worksite health promotion. , ... Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... A recent ... that most people are unfamiliar with. The article goes on to state that individuals ... also many of these less common operations such as calf and cheek reduction. The ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension Association (PHA) ... will receive two significant new grants to support its work to advance research ... anniversary by recognizing patients, medical professionals and scientists for their work in fighting ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... and INDIANAPOLIS , June ... receiving a Lilly Diabetes Tomorrow,s Leaders Scholarship is any ... scholarship winners, announced today online at www.diabetesscholars.org ... type 1 diabetes stand in the way of academic ... supported the Foundation,s scholarship program since 2012, and continues ...
(Date:6/23/2016)... 23, 2016 Revolutionary technology includes ... Oticon , industry leaders in advanced audiology and hearing ... Oticon Opn ™, the world,s first internet connected hearing ... IoT devices.      (Photo: http://photos.prnewswire.com/prnh/20160622/382240 ... number of ,world firsts,: , TwinLink™ - ...
(Date:6/23/2016)... MEDIA, Pa. , June 23, 2016 ... treatments in an outpatient dialysis facility.  Treatments are usually ... to 6 hours per visit, including travel time, equipment ... on a patient, but especially grueling for patients who ... residents of a skilled nursing and rehabilitation centers for ...
Breaking Medicine Technology: