Navigation Links
Researchers Use Gene Therapy to Restore Eyesight in Blind Mice

A new study has used gene therapy to bring back eyesight in mice that had a form of hereditary blindness.

The finding may have an impact on many of the common blinding diseases in humans, researchers now state.

The study was conducted by a team of researchers led by John J. Alexander at the University of Florida.

As part of the study, researchers conducted experiments on mice that had a hereditary blindness called achromatopsia.

This disease affects eyesight by putting cone photoreceptors in the retina out of action. The disease not only causes almost complete color blindness, but also very poor central vision.

As a part of the research the researchers used a harmless virus to provide corrective genes to mice with a genetic impairment that blocks their vision.

Researchers measured the electrical activity in the retinas of mice for two months after the administering the gene therapy injection into the subretinal space of the rodents.

Scientists found that 19 out of the 21 treated eyes responded to therapy positively, and 17 of those 19 had electrical readings from their retinas much similar to those taken in normal mice.

Tests in mice between 6 and 7 months old showed that 18 of the 21 treated eyes responded in a normal manner.

Also, a smaller group of treated mice were assessed with a test similar to doctors eye test. Researchers found that the mice had normal visual perception with their treated eyes.

"People can talk and tell us what they see," Nature quoted Alexander, as saying.

"Animals are much more difficult. What makes this test so fantastic is that it involves an animals natural response, and the results tell us that the animals brains are involved in the process, that they are actually seeing something," he added.

The research shows that it is possible to focus and save cone cells which are th e vital for visual sharpness and color vision in people.

According to Richard Weleber, a professor of molecular and medical genetics at Oregon Health & Science University who was not involved in the research, the study this cone-targeted gene therapy is first on its kind and has great implications for a number of degenerative diseases.

"This is the first to my knowledge of a cone-targeted gene therapy that restores function in an animal model where cones are the primary defect," Weleber said.

"This validates the concept that it is possible to deliver a gene therapy targeting the cone system, and that is incredibly important for a number of degenerative diseases," he added.

The findings of the study were published in the online edition of Nature Medicine.


'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... , ... October 13, 2017 , ... ... throughout Arkansas that offers insurance and financial preparation services, is providing an update ... City Rescue organization. , Rock City Rescue is a locally recognized nonprofit that ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... the certification process to promote standards of excellence for the field of eating ... for March 22 – 25, 2018 in Orlando, Florida at the Omni Resort ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton ... staged a mock evacuation of the facility as part of a disaster drill on ... Echo Hose EMS and Shelton City Emergency Manager, as well as the Connecticut ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual Kids Fun Run ... This free event, sponsored by Global Healthcare Management’s CEO, Jon Letko, is aimed ... geared towards children of all ages; it is a non-competitive, non-timed event, which is ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the Mission ... lost souls in the Philippines. “The Journey: From the Mountains to the Mission Field” ... the Bible. She has taught all ages and currently teaches a class of ladies ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... 10, 2017  NDS received FDA 510(k) clearance in May 2017 ... display stand specifically designed for endoscopy environments. An innovative secondary monitor ... clinical solution to support the improvement of patient outcomes, procedural efficiency, ... ... ...
(Date:10/4/2017)... 4, 2017  According to the Centers for Disease Control and Prevention ... . PhysicianOne Urgent Care is helping communities across Massachusetts ... , by offering no-cost* flu shots through the end of the month. ... health insurance regulations. ... to get a flu shot is by the end of October, according ...
(Date:10/2/2017)... PHILADELPHIA , Oct. 2, 2017 Halo Labs announces ... particle analysis system called the HORIZON at MIBio 2017 in ... analyzes subvisible and visible particulate matter in biopharmaceutical samples with unprecedented ... use of the novel technique Backgrounded Membrane Imaging. ... The HORIZON subvisible particle analysis system ...
Breaking Medicine Technology: