Navigation Links
Researchers Use Gene Therapy to Restore Eyesight in Blind Mice

A new study has used gene therapy to bring back eyesight in mice that had a form of hereditary blindness.

The finding may have an impact on many of the common blinding diseases in humans, researchers now state.

The study was conducted by a team of researchers led by John J. Alexander at the University of Florida.

As part of the study, researchers conducted experiments on mice that had a hereditary blindness called achromatopsia.

This disease affects eyesight by putting cone photoreceptors in the retina out of action. The disease not only causes almost complete color blindness, but also very poor central vision.

As a part of the research the researchers used a harmless virus to provide corrective genes to mice with a genetic impairment that blocks their vision.

Researchers measured the electrical activity in the retinas of mice for two months after the administering the gene therapy injection into the subretinal space of the rodents.

Scientists found that 19 out of the 21 treated eyes responded to therapy positively, and 17 of those 19 had electrical readings from their retinas much similar to those taken in normal mice.

Tests in mice between 6 and 7 months old showed that 18 of the 21 treated eyes responded in a normal manner.

Also, a smaller group of treated mice were assessed with a test similar to doctors eye test. Researchers found that the mice had normal visual perception with their treated eyes.

"People can talk and tell us what they see," Nature quoted Alexander, as saying.

"Animals are much more difficult. What makes this test so fantastic is that it involves an animals natural response, and the results tell us that the animals brains are involved in the process, that they are actually seeing something," he added.

The research shows that it is possible to focus and save cone cells which are th e vital for visual sharpness and color vision in people.

According to Richard Weleber, a professor of molecular and medical genetics at Oregon Health & Science University who was not involved in the research, the study this cone-targeted gene therapy is first on its kind and has great implications for a number of degenerative diseases.

"This is the first to my knowledge of a cone-targeted gene therapy that restores function in an animal model where cones are the primary defect," Weleber said.

"This validates the concept that it is possible to deliver a gene therapy targeting the cone system, and that is incredibly important for a number of degenerative diseases," he added.

The findings of the study were published in the online edition of Nature Medicine.


'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... Overland Park, KS (PRWEB) , ... June 27, 2016 , ... ... leader in retailers of Eyeglasses . , Millions of individuals in the United ... life, eyeglasses have become a way to both correct vision and make a fashion ...
(Date:6/26/2016)... ... ... legally blind and certified personal trainer is helping to develop a weight loss fitness plan ... fix the two major problems leading the fitness industry today:, , ... They don’t eliminate all the reasons people quit their exercise program ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users ... - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 ... Pro X . Simply select a ProHand generator and drag it above media or ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the ... In terms of the latter, setting the bar too high can result in disappointment, ... just slow progress toward their goal. , Research from PsychTests.com reveals ...
(Date:6/24/2016)... ... June 24, 2016 , ... The ... in Dallas that it will receive two significant new grants to support its ... PHA marked its 25th anniversary by recognizing patients, medical professionals and scientists for ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)... -- Guerbet announced today that it has been named a ... One of 12 suppliers to receive the ... of Premier members through exceptional local customer service and ... lower costs. "We ... customer service from Premier," says Massimo Carrara , ...
Breaking Medicine Technology: