Navigation Links
Researchers Uncover Gene That Raises Risk for Type 1 Diabetes

A discovery at the Barbara Davis Center for Childhood Diabetes has identified a genetic risk for type 1 diabetes three to four times higher than previously thought possible.// Researchers have found evidence of an additional gene – gene X – in the human leukocyte antigen (HLA) region on chromosome 6 that raises the risk for type 1 diabetes autoimmunity to an astounding 80 percent.

It has been known for some time that approximately 5 percent of individuals with known high risk genes in the HLA region on chromosome 6 will develop type 1 diabetes – a region comprised of more than 220 genes. Past research identified specific HLA-DR and HLA-DQ genes as genetic markers that when passed on to offspring of a diabetic parent determined a risk for type 1 diabetes in a child. Investigators have been searching for other genes determining diabetes risk, looking primarily at genetic regions outside of the HLA region. The current research from the Barbara Davis Center evaluated the influence of additional genes in the HLA region.

Beginning in 1993, more than 30,000 newborns in Colorado were genetically typed at birth through the Diabetes Autoimmunity Study in the Young (DAISY), a study led by Dr. Marian Rewers, clinical director of the Barbara Davis Center. Those with high risk HLA-DR and HLA-DQ genes were followed and monitored for the development of anti-islet cell autoimmunity in the pancreas (pre-diabetes) and diabetes.

“By combining measurement of high risk HLA-DR and HLA-DQ genes with defined family analysis we found that type 1 diabetes is more a Mendelian genetic disease that follows the basic principles of heredity,” said George Eisenbarth, MD, PhD, executive director of the Barbara Davis Center for Childhood Diabetes. “We found an extreme risk – greater than 80 percent – determined at birth by combining HLA-DR and HLA-DQ genetic typing with inheritance of other genes in the HLA region of chromosome 6. This research indicates an unexpec ted genetic determination of type 1 diabetes with a major unknown genetic locus and suggests that future research should concentrate on defining the additional genes in the HLA region that cause diabetes.”

The research also brings to light a possibility to prevent childhood diabetes in the future. The authors indicate that “infants and children who have the highest genetic risk for diabetes as defined by this study are an important group that may now be considered for initial clinical trials to prevent childhood diabetes before the development of anti-islet autoantibodies.”

In the meantime, parents should be alert to the symptoms of type 1 diabetes usually first seen in childhood. Symptoms can include extreme thirst, frequent urination, and rapid weight loss. If symptoms are left unchecked, an onset of diabetes could be fatal.

“If a child is severely ill with an unknown cause, parents should think about diabetes,” Eisenbarth said. “A child can be easily tested for diabetes. If a diagnosis is delayed at the onset of diabetes, children can die – it is preventable if children are tested.” Eisenbarth indicated there is a national trial organization that tests relatives of patients with diabetes for risk.



Source-ewswise
SRM
'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/12/2016)... ... 2016 , ... The Jones Agency, a family owned insurance company with offices ... cooperative charity drive with the Tarrant Area Food Bank in the hopes of alleviating ... in need, the Tarrant County Food Bank offers hope and security to the one ...
(Date:2/12/2016)... ... 2016 , ... Miami Dental Specialists is excited to bring patients the choice ... in January, Miami Dental Specialists will offer the non-metal implants as a safe, holistic ... be chosen by the dental implant manufacturer, Straumann, to bring this cutting-edge technology to ...
(Date:2/12/2016)... , ... February 12, 2016 , ... ... Drug Categories: Strategies for Health Plans and PBMs,” an upcoming Feb. 24 webinar ... affordability and access in big-dollar therapeutic categories, such as the $1,000-per-pill hepatitis C ...
(Date:2/12/2016)... LUIS OBISPO, Calif. (PRWEB) , ... February 12, 2016 , ... The Central Coast Autism ... of this dance is to provide a night of fun for teens with and without ... help everyone feel welcomed and included at the event. The dance will take place on ...
(Date:2/12/2016)... ... February 12, 2016 , ... With the exception of restorative dentistry, to date there has ... With the recent approval by the FDA, there is a now a new protocol in ... SDF is very simple and quick to apply. The application is as simple as ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... VIEJO , Kalifornien, 12. Februar 2016 /PRNewswire/ ... mit der Aufnahme von Patienten für eine Studie ... von Aneurysmen („WEB") speziell für die Behandlung von ... Spelle , MD, Leiter der Neuroradiologie an der ... Frankreich, und Hauptprüfarzt der CLARYS-Studie hat den ersten ...
(Date:2/12/2016)... and SEOUL, South Korea ... Menarini and Macrogen, Inc. today announced they will ... innovative procedures for precision medicine in cancer. The ... Biosystems, DEPArray™ digital-sorting technology with Macrogen,s high-throughput Next ... certified under the Clinical Laboratory Improvement Amendments (CLIA) ...
(Date:2/12/2016)... 12 februari 2016 AAIPharma Services ... leverancier van productie en ontwikkeling op maat ... vandaag een uitbreiding aan van steriele vul- ... in Charleston, SC . ... meerdere recente investeringen. http://photos.prnewswire.com/prnh/20150806/256637LOGO ...
Breaking Medicine Technology: