Navigation Links
Researchers Uncover Gene That Raises Risk for Type 1 Diabetes

A discovery at the Barbara Davis Center for Childhood Diabetes has identified a genetic risk for type 1 diabetes three to four times higher than previously thought possible.// Researchers have found evidence of an additional gene – gene X – in the human leukocyte antigen (HLA) region on chromosome 6 that raises the risk for type 1 diabetes autoimmunity to an astounding 80 percent.

It has been known for some time that approximately 5 percent of individuals with known high risk genes in the HLA region on chromosome 6 will develop type 1 diabetes – a region comprised of more than 220 genes. Past research identified specific HLA-DR and HLA-DQ genes as genetic markers that when passed on to offspring of a diabetic parent determined a risk for type 1 diabetes in a child. Investigators have been searching for other genes determining diabetes risk, looking primarily at genetic regions outside of the HLA region. The current research from the Barbara Davis Center evaluated the influence of additional genes in the HLA region.

Beginning in 1993, more than 30,000 newborns in Colorado were genetically typed at birth through the Diabetes Autoimmunity Study in the Young (DAISY), a study led by Dr. Marian Rewers, clinical director of the Barbara Davis Center. Those with high risk HLA-DR and HLA-DQ genes were followed and monitored for the development of anti-islet cell autoimmunity in the pancreas (pre-diabetes) and diabetes.

“By combining measurement of high risk HLA-DR and HLA-DQ genes with defined family analysis we found that type 1 diabetes is more a Mendelian genetic disease that follows the basic principles of heredity,” said George Eisenbarth, MD, PhD, executive director of the Barbara Davis Center for Childhood Diabetes. “We found an extreme risk – greater than 80 percent – determined at birth by combining HLA-DR and HLA-DQ genetic typing with inheritance of other genes in the HLA region of chromosome 6. This research indicates an unexpec ted genetic determination of type 1 diabetes with a major unknown genetic locus and suggests that future research should concentrate on defining the additional genes in the HLA region that cause diabetes.”

The research also brings to light a possibility to prevent childhood diabetes in the future. The authors indicate that “infants and children who have the highest genetic risk for diabetes as defined by this study are an important group that may now be considered for initial clinical trials to prevent childhood diabetes before the development of anti-islet autoantibodies.”

In the meantime, parents should be alert to the symptoms of type 1 diabetes usually first seen in childhood. Symptoms can include extreme thirst, frequent urination, and rapid weight loss. If symptoms are left unchecked, an onset of diabetes could be fatal.

“If a child is severely ill with an unknown cause, parents should think about diabetes,” Eisenbarth said. “A child can be easily tested for diabetes. If a diagnosis is delayed at the onset of diabetes, children can die – it is preventable if children are tested.” Eisenbarth indicated there is a national trial organization that tests relatives of patients with diabetes for risk.



Source-ewswise
SRM
'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/22/2017)... ... September 22, 2017 , ... ... tick-borne diseases through research, education and awareness, today announced the appointment of Timothy ... and microbiologist, Dr. Sellati has more than 20 years of research experience with ...
(Date:9/21/2017)... ... September 21, 2017 , ... ... — 1:30 p.m. – 3:00 p.m. ET, http://www.fdanews.com/processcapabilityindices      ... things wrong, run afoul of The Quality System Regulation (§820.250), and Devicemakers find ...
(Date:9/21/2017)... ... September 21, 2017 , ... Promotional ... http://www.fdanews.com/products/54818-promotional-communication      , In the competitive world of drug and device marketing ... in compliance with FDA rules. , The FDA has issued two draft guidances ...
(Date:9/21/2017)... ... September 21, 2017 , ... Bill Howe Plumbing’s mission is to create ... back to the community. For over 37 years, they have operated with their mission ... plumbing in San Diego. They were chosen as the Best San Diego plumber ...
(Date:9/21/2017)... Southborough, Mass. (PRWEB) , ... September 21, 2017 , ... ... for children with autism, announced today the election of Yie-Hsin Hung to the Board ... Yie-Hsin Hung join our Board of Directors. Ms. Hung is an invaluable addition to ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... BOTHELL, Wash. , Sept. 7, 2017   BioLife ... developer, manufacturer and marketer of proprietary clinical grade cell and ... media ("BioLife"), announces that Mike Rice , President and ... Rodman & Renshaw 19 th ... 3:25 p.m. Eastern time (12:25 p.m. Pacific time). The conference ...
(Date:9/6/2017)... 2017 Eli Lilly and Company (NYSE: ... data for galcanezumab and lasmiditan, two investigational treatments for ... Society (IHC) taking place Sept. 7-10 in ... new, long-term data from an open-label study evaluating the ... mg and 240 mg) for the prevention of migraine. ...
(Date:9/5/2017)... Oramed Pharmaceuticals Inc. (NASDAQ: ORMP ) (TASE: ... on the development of oral drug delivery systems, announced ... the U.S. Food and Drug Administration (FDA) regarding ORMD-0801, ... At the meeting, the FDA gave ... ORMD-0801, would be a Biologics License Application (BLA).  Such ...
Breaking Medicine Technology: