Navigation Links
Researchers Uncover Critical Player in Cell Communication

I outside the cell nucleus led us to suspect that this protein must be doing more than regulate gene expression,” says Desiderio.

Under normal conditions, calcium does not flow freely into and out of cells until a demand for it - such as a muscle contraction or nerve function -- triggers cells to take up the free floating element from their surroundings. Cells store calcium until still other signals occur to release it again.

“The finding was stunning to us because calcium is one of the most important messengers in cells,” says Desiderio, “and both it and TFII-I are in every cell. That affirmed our suspicion that TFII-I could be doing something important with calcium signaling.”

In one experiment, the Hopkins team knocked down the amount of TFII-I in lab-grown cells and looked for changes in calcium flow under a high-power microscope using a dye that glows when it comes in contact with calcium. A camera attached to the microscope recorded the brightness of the glow and fed that measure into a computer that calculates the amount of calcium.

Knocking down TFII-I and separately assaulting the cells with chemicals caused the cells to take up more calcium than usual.

The researchers realized that when they depleted the cells of TFII-I, the cell responded by installing more calcium channels in their surfaces that allow calcium and only calcium to enter the cell. “We think TFII-I must control calcium entry into the cell by somehow limiting the number of calcium channels at the cell’s surface,” says Desiderio.

“There’s good evidence suggesting that the frequency and intensity of this ebb and flow of calcium can determine a cell’s response to external cues,” says Desiderio. “TFII-I may be a universal player in communication between cells, in the brain, the immune system and elsewhere.”
Source-Newswise
SRM
'"/>




Page: 1 2

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers Uncover Critical Player Cell Communication

(Date:7/29/2014)... Some people can handle stressful situations better than ... Even identical twins show differences in how they ... pattern in the brains of genetically identical mice ... in stressful situations. , The findings, published ... eventually help researchers prevent potential consequences of chronic ...
(Date:7/29/2014)... 29, 2014 Healthcare staffing agency ... Nurses of Tomorrow Scholarship Competition winners:, ... NV ,     Racheal D., Freshman, Cerritos College ... Houston Community College in Houston, TX ... Medical Solutions hosts the Nurses of Tomorrow Scholarship ...
(Date:7/29/2014)... 29, 2014 Catalent Pharma Solutions, ... advanced delivery technologies for pharmaceutical, biologic, and consumer ... R&D Director and US Platform Leader of Pharmaceutical ... Drugs with Lipid-Based Formulations using Soft Capsule Delivery ... the Japan Society of Drug Delivery Systems (30-31 ...
(Date:7/29/2014)... The Affordable Care Act has created a ... Studies show that over 400 hospitals probably won’t survive ... tool that great hospitals use to survive the threat ... Their secret? Debriefing - the simple process of systematically ... an operational event. Debriefing is a standard procedure in ...
(Date:7/29/2014)... Dennis Thompson HealthDay Reporter ... live an average three years longer than people who don,t run, ... this study is that it appears that you can reap this ... every day, the 15-year study suggests. "People may not ... author Duck-chul Lee, an assistant professor of kinesiology at Iowa State ...
Breaking Medicine News(10 mins):Health News:A new brain-based marker of stress susceptibility 2Health News:Medical Solutions Announces Nurses of Tomorrow Scholarship Winners 2Health News:Catalent Expert to Present on Enhancing Bioavailability of Poorly Absorbed Drugs at Japan Society of Drug Delivery Systems 2Health News:One Brilliant Economic Survival Tool You Can Steal from the World's Best Hospitals 2Health News:One Brilliant Economic Survival Tool You Can Steal from the World's Best Hospitals 3Health News:Running Could Add 3 Years to Your Lifespan 2Health News:Running Could Add 3 Years to Your Lifespan 3
... Dr. Neil Kurtz Resigns as President and Chief Executive Officer; ... Graham Appointed Acting Chief Executive Officer -, LA ... ) today announced that Neil Kurtz, M.D., is,resigning as President, ... of August 31, 2008. Dr. Kurtz is leaving TorreyPines,to assume ...
... genetic variation , , FRIDAY, Aug. 8 (HealthDay News) -- A ... salt intake and high blood pressure. , The study, which ... possible genetic factor that might make people more or less ... -- variants of a gene for angiotensinogen, a molecule that ...
... polar opposite diseases, but both depend upon dopamine in ... drug addicts get too much of it. Although the ... known, the way it works has been a mystery. ... Medicine has revealed that dopamine strengthens and weakens the ...
... release is available in French . , ... that patients who receive early treatment for Hepatitis C ... develop a rapid poly-functional immune response against HCV similar ... new study published in the Journal of Virology ...
... Delayed diagnosis, less successful surgery, pair of studies finds , , ... for prostate cancer may not be accurate for obese men, ... less likely to be effective for them, a new pair ... be diagnosed with an aggressive form of the disease," said ...
... in Senior Housing Growing; Adoption of Healthy Lifestyle ... ... the face of conventional,wisdom, which has long proven true, women live longer ... than ever are moving,into senior living residences nationwide. Historically female-dominated,senior living communities ...
Cached Medicine News:Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 2Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 3Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 4Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 5Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 6Health News:TorreyPines Therapeutics Announces Management Change and Second Quarter 2008 Financial Results 7Health News:Too Much Salt Boosts Blood Pressure 2Health News:Why dopamine freezes parkinson patients and drives drug addicts 2Health News:Why dopamine freezes parkinson patients and drives drug addicts 3Health News:Early treatment is key to combating hepatitis C virus 2Health News:Obese Men Face Twin Threat From Prostate Cancer 2Health News:More Men Moving Into Senior Residences 2Health News:More Men Moving Into Senior Residences 3
(Date:7/29/2014)... VIENNA , July 29, 2014 ... Vienna, Austria will present data from a ... that aims to slow or stop Parkinson,s disease progression. ... a $ 1.5 million grant and will discuss the impact ... community. When:   Thursday, July 31, 2014 ...
(Date:7/29/2014)... 2014   Abide Therapeutics announced today ... its board of directors. Thornberry was previously senior ... for Merck & Co. Inc., where she led ... in diabetes, osteoporosis, fertility and contraception. Thornberry, a ... that resulted in the discovery of Januvia TM ...
(Date:7/29/2014)... Today, Frost & Sullivan recognizes Validic ... Practices Award for Customer Value Leadership. The Validic ... connects digital health application developers, medical devices and ... prevention and wellness companies, population health management companies ... Frost & Sullivan presents this award to a ...
Breaking Medicine Technology:Reminder/Media Advisory/AFFiRiS AG Presents Early Clinical Data on a First-of-its-Kind Parkinson's Disease Vaccine 2Abide Therapeutics Appoints Nancy Thornberry to Board of Directors 2Abide Therapeutics Appoints Nancy Thornberry to Board of Directors 3Frost & Sullivan Commends Validic for Delivering Superior Customer Value through its mHealth Interoperability Technology Platform 2Frost & Sullivan Commends Validic for Delivering Superior Customer Value through its mHealth Interoperability Technology Platform 3Frost & Sullivan Commends Validic for Delivering Superior Customer Value through its mHealth Interoperability Technology Platform 4
Single step suture passage is made simple with Arthro-Pierce instruments. The low profile, highly sharpened tip allows easy passage through tissue in order to retrieve or apply suture....
12" suture passer...
Arthrex has the most extensive offering of arthroscopic suture passing instruments,available anywhere in the world. We have speci? cally designed the function of our,instruments to work hand in hand ...
Arthrex has the most extensive offering of arthroscopic suture passing instruments,available anywhere in the world. We have speci? cally designed the function of our,instruments to work hand in hand ...
Medicine Products: