Navigation Links
Researchers On The Path To Building Bone

UAB (University of Alabama at Birmingham) researchers have developed a method to increase bone density in mice, a development that might have future benefit for humans in// the treatment of osteoporosis and bone fracture. The research, published in the Jan. 29 issue of Proceedings of the National Academy of Sciences, involves manipulation of the Pten gene, which contributes to the process by which cells die, known as apoptosis.

“Bone density can increase either because more bone cells divide or fewer cells die due to apoptosis. Pten is a tumor suppressor gene that applies a break on the main cell survival pathway, causing cells to die,” said Thomas L. Clemens, Ph.D., professor of pathology and director of the UAB Division of Molecular and Cellular Pathology. “We devised a way to remove the Pten break in bone cells, allowing the cells to stay alive and active for a longer period of time.”

Clemens, a scientist in the UAB Center for Metabolic Bone Disease, and his colleagues disrupted Pten in bone cells called osteoblasts in mice. The mice with Pten disruption, while normal sized, had dramatic and progressively increasing bone density throughout life compared to controls.

“In the mice without Pten, osteoblast cells survived longer and continued to make new bone long after they ordinarily would have died,” Clemens said. “This increased osteoblast production led to greater bone density. If we can translate these findings to human conditions such as osteoporosis or bone fracture, we can potentially not only prevent bone loss, but actually increase bone density in humans as they age.”

Humans lose bone as they age, in part because of the loss of osteoblast cells that have died, leading to conditions such as osteoporosis or its predecessor, osteopenia.

While there are medications available to treat these conditions by slowing bone loss, there are no agents that contribute to building new bone and increasing bone de nsity after it has already been lost.

Clemens stresses that this research is in the very early stages and it could be years before treatments for human conditions would be possible.

“The key will be to find a way to selectively turn off Pten only in bone-making osteoblasts and leave other cells in the body unaffected,” Clemens said. “Pten plays an important role in the body by killing cell lines that are proliferating out of control, as in tumors.”


Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:

(Date:6/26/2016)... , ... June 27, 2016 , ... Quality metrics are ... in many ways they remain in the eye of the beholder, according to experts ... publication of The American Journal of Managed Care. For the full issue, click ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified ... be personalized through a fitness app. The fitness app plans to fix the two major ... only offer a one size fits all type program , They don’t eliminate ...
(Date:6/25/2016)... ... ... The temporary closing of Bruton Memorial Library on June 21 due to a possible lice ... overlooked aspect of head lice: the parasite’s ability to live away from a human host, ... a necessary one in the event that lice have simply gotten out of control. , ...
(Date:6/25/2016)... Oklahoma (PRWEB) , ... June 25, 2016 , ... ... both athletes and non-athletes recover from injury. Recently, he has implemented orthobiologic procedures ... Oklahoma City area —Johnson is one of the first doctors to perform the ...
(Date:6/24/2016)... , ... June 24, 2016 , ... Those who have ... these feelings, many turn to unhealthy avenues, such as drug or alcohol abuse, as ... Michigan, has released tools for healthy coping following a traumatic event. , Trauma sufferers ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Research ... Devices Global Market - Forecast to 2022" report to ... the treatment method for the patients with kidney failure, it ... excess fluid from the patient,s blood and thus the treatment ... potassium and chloride in balance. Increasing number ...
(Date:6/23/2016)... -- Roche (SIX: RO, ROG; OTCQX: RHHBY) announced that ... PCT (procalcitonin) assay as a dedicated testing solution for ... clearance, Roche is the first IVD company in the ... risk assessment and management. PCT is a ... in blood can aid clinicians in assessing the risk ...
(Date:6/23/2016)... 2016 Bracket , a leading clinical trial ... clinical outcomes platform, Bracket eCOA (SM) 6.0, at the ... – 30, 2016 in Philadelphia , Pennsylvania.  ... Assessment product of its kind to fully integrate with RTSM, ... eCOA 6.0 is a flexible platform for electronic clinical outcomes ...
Breaking Medicine Technology: