Navigation Links
Researchers On The Path To Building Bone

UAB (University of Alabama at Birmingham) researchers have developed a method to increase bone density in mice, a development that might have future benefit for humans in// the treatment of osteoporosis and bone fracture. The research, published in the Jan. 29 issue of Proceedings of the National Academy of Sciences, involves manipulation of the Pten gene, which contributes to the process by which cells die, known as apoptosis.

“Bone density can increase either because more bone cells divide or fewer cells die due to apoptosis. Pten is a tumor suppressor gene that applies a break on the main cell survival pathway, causing cells to die,” said Thomas L. Clemens, Ph.D., professor of pathology and director of the UAB Division of Molecular and Cellular Pathology. “We devised a way to remove the Pten break in bone cells, allowing the cells to stay alive and active for a longer period of time.”

Clemens, a scientist in the UAB Center for Metabolic Bone Disease, and his colleagues disrupted Pten in bone cells called osteoblasts in mice. The mice with Pten disruption, while normal sized, had dramatic and progressively increasing bone density throughout life compared to controls.

“In the mice without Pten, osteoblast cells survived longer and continued to make new bone long after they ordinarily would have died,” Clemens said. “This increased osteoblast production led to greater bone density. If we can translate these findings to human conditions such as osteoporosis or bone fracture, we can potentially not only prevent bone loss, but actually increase bone density in humans as they age.”

Humans lose bone as they age, in part because of the loss of osteoblast cells that have died, leading to conditions such as osteoporosis or its predecessor, osteopenia.

While there are medications available to treat these conditions by slowing bone loss, there are no agents that contribute to building new bone and increasing bone de nsity after it has already been lost.

Clemens stresses that this research is in the very early stages and it could be years before treatments for human conditions would be possible.

“The key will be to find a way to selectively turn off Pten only in bone-making osteoblasts and leave other cells in the body unaffected,” Clemens said. “Pten plays an important role in the body by killing cell lines that are proliferating out of control, as in tumors.”

Source-Newsise
SRM
'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/23/2017)... ... 2017 , ... Hamlin Dental Group and Dr. Hamid Reza, dentist in ... the month of February, patients who visit Hamlin Dental Group will receive a ticket ... two at the Cheesecake Factory. , Tickets are available for routine dental visits ...
(Date:2/23/2017)... Henderson, Nevada (PRWEB) , ... February 23, 2017 , ... ... Eastern Avenue in Henderson, NV 89052. Dr. Mahon was named a 2017 Top Patient ... Local Doctors is an online directory that recognizes local physicians and dentists who ...
(Date:2/23/2017)... ... February 23, 2017 , ... Healthcare Research & Analytics® (HRA®) ... fight against cancer, has produced a seminal study that asked cancer survivors and ... findings in a webinar, Defining Compassionate Care Through the Voices of Patients and ...
(Date:2/23/2017)... (PRWEB) , ... February 23, 2017 , ... Top cosmetic ... Smiling Patriot program today with a new Indiegogo campaign . Individuals are ... homeless veterans in the Los Angeles area, either as a participating patient or through ...
(Date:2/23/2017)... Va. (PRWEB) , ... February 23, 2017 , ... ... or problems. He has also continued to spiritually evolve, which is the purpose of ... book “ Our Spiritual Truths ” (published by Balboa Press) attempts to guide readers ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... and VANCOUVER, British Columbia , Feb. ... OGXI ) today announced its year end 2016 financial ... In January 2017, OncoGenex, and Achieve Life Science, Inc., a ... entered into a definitive merger agreement under which OncoGenex ... of the proposed merger, Achieve,s stockholders are expected to ...
(Date:2/23/2017)... 22, 2017 This report analyzes analyzes the worldwide markets ... separate comprehensive analytics for the US, Canada ... , Asia-Pacific , Latin America ... are provided for the period 2015 through 2022. Also, a ... and analytics are derived from primary and secondary research. Company ...
(Date:2/23/2017)... YORK , Feb. 22, 2017 Medical ... medical intervention. Medical imaging is performed to reveal the ... examine and diagnose the medical condition. It plays a ... the treatment process as it is taken into consideration ... medical imaging include X-rays, SPECT/PET, ultrasound, CT, and MRI. ...
Breaking Medicine Technology: