Navigation Links
Researchers Make Strides in VCJD Detection

A way of reversing brain impairment that strikes in the early stages of prion diseases such as vCJD and BSE has been identified by scientists.//

The findings suggest there may be a way to cure vCJD, the human form of BSE, if it can be detected before it has time to kill off large numbers of brain cells.

The disease has so far claimed the lives of 158 people in Britain, and seven more are known to be infected. But many scientists believe that thousands more may be harboring the disease but have yet to develop symptoms.

Prion diseases are caused when abnormal forms of natural proteins called prions get into the blood stream and force proteins already in the body to retract and suffocate brain cells.

Researchers led by Giovanna Malucci at the MRC prion unit at University College, London (UCL), used genetically modified mice to show that blocking the body's ability to make its own natural, healthy prions, reversed early symptoms of the disease.

They infected mice with abnormal prions and found they began to develop disease. But when the mice stopped producing their own prions, their symptoms cleared up.

"A psychologically healthy mouse will make nests and burrow, but they lose that early in the disease, they get withdrawn and depressed and lose their exploratory capacity," said Dr Malucci. "What we've shown is we can reverse that and get full functional recovery."

Major hurdles remain before the finding could be used as a cure. There is still no test that can detect vCJD infection before symptoms develop and no known drugs can switch off the production of healthy prions in humans.

"If there was a diagnostic test for humans that could pick the disease up early, hopefully there would be a potential for recovery with this treatment," Dr Malucci added. The study appears in the journal Neuron.

The UCL team is screening a vast array of drugs to identify if any can be used to stop prion production, but the next step in their research will investigate whether gene therapy can be used to switch off prion production in mice once they have developed prion disease.

This month, the government launched its first concerted effort to find out how common vCJD infection is in the general population by beginning vCJD tests on 100,000 pairs of tonsils gathered from operations around the country.

Source-Bio-Bio Technology
SRI
'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... ... “The Journey: From the Mountains to the Mission Field”: the story of a ... “The Journey: From the Mountains to the Mission Field” is the creation of published ... all ages and currently teaches a class of ladies at her church, which she ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... , ... Asante, a nationally recognized health system in southern ... home health joint venture through an agreement, effective October 1, 2017, to create ... health company with Asante, delivering clinically integrated care, for the past eight years. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at Children’s National ... 49th Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. ... for Cancer and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... $3,296 in property taxes a year. In some states—like New York, New Jersey, ... By contrast, many overseas retirement havens have extremely low property-tax rates, which contributes ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... Texas , Oct. 6, 2017   Provista, ... with more than $100 billion in purchasing power, today ... news and information. The Newsroom is the ... and industry trends, infographics, expert bios, news releases, slideshows ... having access to a wealth of resources at their ...
(Date:10/4/2017)... -- According to the Centers for Disease Control and Prevention (CDC), influenza ... Care is helping communities across Massachusetts , ... no-cost* flu shots through the end of the month. *Some ... ... flu shot is by the end of October, according to the Centers ...
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and ... financial results for the third quarter of 2017 on ... conference call on that day with the investment community ... The conference call will begin at 9 ... can access a live webcast of the conference call ...
Breaking Medicine Technology: