Navigation Links
Researchers Locate Genetic Link for Nicotine Dependence Among African Americans

Scientists at the University of Virginia Health System have identified, for the first time ever, several genetic regions that are likely to carry the genes for nicotine// dependence (ND) in an African American population. This is the first genome-wide study of such linkage and included the largest group of African Americans to participate in this type of linkage study. Until this study, participants in research to find genetic links to ND have been primarily of European origin.

This new study is important because there are known differences in smoking patterns and in ND risk across ethnic groups. Analysis of twin studies on smoking behavior showed that genetic factors are responsible for at least 50 percent of a person’s tendency toward dependence on nicotine.

“Identifying the genes that predispose a person to nicotine dependence and understanding the molecular mechanisms are vital to prevention and treatment,” said lead author Ming Li, Ph.D., associate professor and head of the Neurobiology Section of the UVa Department of Psychiatric Medicine. "Given the potential ethnic differences in smoking patterns and nicotine metabolism, this study may suggest strategies for identifying genes for tobacco dependence, especially among African American smokers.” This could lead to potential targeted treatments in the future.

Such genome-wide studies are arduous, but they yield valuable information. “Without knowing these regions, we would have no place to start, given that everybody has 22 autosomal chromosomes and two sex chromosomes with about 40,000 genes located throughout the genome,” Dr. Li explained.

The researchers conducted a genome-wide scan of 1,261 individuals representing 402 nuclear families of African American origin, the largest sample collection of African-American smokers throughout the world. Their results revealed a region on chromosome 10 that showed a significant linkage to smoking quantity and other measures of smoking dependence. They also identified three other regions that met the criteria for linkage to at least one ND measure. Some of these regions have been linked to smoking behavior previously, which adds supporting data to the previous studies of nicotine dependence in other populations.


Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:

(Date:11/26/2015)... ... November 26, 2015 , ... ... eReferral system for diagnostic imaging in the Waterloo region. Using the Ocean Platform, ... Medicine tests directly from their electronic medical record (EMR) without the need for ...
(Date:11/26/2015)... ... , ... Jobs in hospital medical laboratories and in the imaging field lead ... Aureus Medical Group . These fields, as well as travel nursing, ... healthcare jobs through the company’s website, , The leading healthcare staffing ...
(Date:11/26/2015)... , ... November 26, 2015 , ... ... set of retro-fused, self-animating trailer titles with ProTrailer: Vintage. This newly styled ProTrailer ... classically-influenced trailer titles work with any font, giving users limitless opportunities to stylize ...
(Date:11/25/2015)... ... November 25, 2015 , ... Additional breast cancers found ... mammography, according to a study published online in the journal Radiology. Researchers said ... may necessitate a change in treatment. , Breast MRI is the most sensitive ...
(Date:11/25/2015)... ... November 25, 2015 , ... Finnleo, a leader in ... on several models of traditional and far-infrared saunas. , For traditional saunas, ... the most traditional Finnish sauna wood, and Finnleo uses only European Grade A Nordic ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... 26, 2015 ... the "2016 Global Tumor Marker Testing ... and Sales Segment Forecasts, Innovative Technologies, Instrumentation ... to their offering. --> ... "2016 Global Tumor Marker Testing Market: ...
(Date:11/26/2015)... Bajos, November 26, 2015 Un ... de Bremachlorin para el cáncer avanzado.   ... la terapia fotodinámica de Bremachlorin para el cáncer avanzado. ... combina la inmunoterapia con la terapia fotodinámica de Bremachlorin ... Cancer Research . --> Clinical Cancer Research ...
(Date:11/26/2015)... UTRECHT, the Netherlands , November 26, 2015 /PRNewswire/ ...   A new combination approach blends immunotherapy ... --> A new combination approach blends immunotherapy with ... A new combination approach blends immunotherapy with ... the Netherlands has found that immunotherapy ...
Breaking Medicine Technology: