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Researchers Link Bacteria Destroying Proteins to Alzheimer's Treatment

at although, clinical trials need to be conducted as soon as possible to help alleviate the suffering of the increasing number of Alzheimer's patients, more research is still needed both to understand how amyloid beta proteins wreak havoc in the brain and to improve potential drugs.

Gouras and his colleagues are now trying to figure out how the protein clusters inside and outside the cells work together to destroy the cells. They already noticed that the clusters outside the cells affect those inside cells by making them grow. Another challenge will be to better understand what the clusters do inside the cells that lead to their death. The scientists are also using imaging and biochemical techniques to see, in cultured cells, how the antibodies affect the clusters.

"We have many indications that antibodies work. Now we need to understand how they do it," Gouras said.

The study appears in the June 29 issue of the Journal of Biological Chemistry.


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