Navigation Links
Researchers Investigate Gene Linked With Circadian Liver Clock

Anyone who has experienced jet lag will understand the importance of a smooth-running circadian clock. Crossing time zones decouples our biological rhythms// from the natural cycle of light and dark we’re used to. We perceive light cues through retinal photoreceptors that relay signals to the suprachiasmatic nucleus (SCN) in the brain.

"Phase adjustments" in peripheral tissues ensure that each clock follows the same schedule. These can be set indirectly through SCN-dependent biological rhythms, such as feeding cycles or body temperature. How synchronizing cues operate at the molecular level, however, remains obscure. One key question is whether cyclically expressed genes in peripheral tissues are controlled by local circadian clocks or by systemic cues that are directly or indirectly controlled by the SCN pacemaker.

In a new study published online this week in the open access journal PLoS Biology, Beno?t Kornmann, Ueli Schibler, and colleagues investigated circadian genes in the liver to try and answer this question. To determine whether genes were under local or systemic control, they generated a mouse strain with conditionally active liver clocks that they could turn on or off at will.

The authors modified a transcription factor called REV-ERBa that shuts down circadian gene expression via suppression of a clock gene Bmal1. The modified gene had tetracycline-responsive elements (TREs) that respond to tetracycline and similar antibiotics. Mice with this modification were bred with a strain carrying a gene construct that activates the elements specifically in liver cells. In transgenic offspring fed with tetracycline-like doxycyline (Dox), Rev-erba remained silent in liver cells and Bmal1 functioned normally. In the absence of Dox, transgenic offspring overexpressed REV-ERBa, and Bmal1 was inactive, effectively turning off the liver clocks.

When the authors performed a genome-wide scan of the expression of genes targeted by
'"/>




Page: 1 2 3

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers Investigate Gene Linked With Circadian Liver Clock

(Date:12/26/2014)... (PRWEB) December 26, 2014 The Biofeedback ... place March 24-28, 2015 in Rome, Italy and is ... includes workshops on a wide variety of ... well as peak performance training in athletes. The scientific ... the world. , Biofeedback monitoring allows clients to see ...
(Date:12/26/2014)... December 26, 2014 DW-InductionHeating.com (DaWei Induction ... designing, researching and developing, producing and marketing of a ... the business announces their new series of induction ... of the company, induction brazing refers to ... special filler material and heat. The manager says that ...
(Date:12/25/2014)... Dallas, TX (PRWEB) December 26, 2014 ... and Market Analysis to 2023” focuses on the ... commercial opportunities in the colorectal cancer market. Stivarga ... treatment of colon or rectal cancer. Boehringer Ingelheim ... inhibitor, for the treatment of refractory CRC in ...
(Date:12/25/2014)... Recently, Dylan Queen, a famous online company ... collection of discounted prom dresses, most of which are ... of the company, the promotion is valid until Jan. ... expand the UK market. , The prom dresses in ... and styles: A-line strapless, empire strapless chiffon, one shoulder, ...
(Date:12/25/2014)... 2014 When head lice hits a home ... frenzy to get rid of it while keeping it from ... Gables now have the solution right in their neighborhood: ... Lice Troopers provides full spectrum head lice screening and treatment ... including Sunset, Key Biscayne, Brickell, Coconut Grove, Kendall, Pinecrest and ...
Breaking Medicine News(10 mins):Health News:Final Workshop Line-up Announced for 18th Annual Biofeedback Conference in Rome, Italy 2Health News:Induction Brazing Equipment Series From DaWei Induction Heating Co., A Reliable Supplier Of Induction Heating Equipment 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 2Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 3Health News:Nintedanib Colorectal Cancer Market Analysis and Forecast to 2023 Report at RnRMarketReserach.com 4Health News:Dylan Queen: Cheap Prom Dresses for the UK Market 2Health News:Coral Gables Florida Gets Ready to Be Lice-Free with Lice Troopers 2
... Cipla has offered to manufacture an antiviral drug for ... by Glaxo Smithkline. It has already made Tamiflu in its ... well known and popular as Tamiflu has but is cheaper ... Hameid, CEO of Cipla in a press release said:‘‘Zanamivir is ...
... as the first most common cause for death in ... stress echocardiography that can help predict life-threatening heart problems ... conducted among a group of diabetic women aged between ... type of stress test for suspected coronary disease that ...
... form chronic back pain, an increasing attention is being ... study has established that chiropractic care produces significantly // ... underwent the therapy had higher pain relief and satisfaction ... medical care. , ,The study has been conducted ...
... detected by using a hand-held scope called VELscope, which has ... by National Institute of Dental Craniofacial Research. The devise emits ... white light in detection of cancerous lesions in the mouth. ... oral cancer as better treatment is achieved when oral cancer ...
... National Laboratory are studying the biopolymer structural dynamics of ... new theory on protein folding unfolds the mystery of ... to diseases and the study is to be published ... Sciences. , ,The researchers used a technique called ...
... Britain can look forward to some relief, as a cannabis-based ... time, following approval from the Home Office for its importation ... be able to obtain an unlicensed, cannabis-based medicine on prescription ... it is yet to be licensed in the UK. The ...
Cached Medicine News:Health News:Cipla In India Can Manufacture Drug For Bird Flu 2Health News:Cipla In India Can Manufacture Drug For Bird Flu 3Health News:A Simple Test To Detect Heart Disease In Women Can Be Lifesaving 2Health News:Back Pain Can Now Be Cost-Effectively Treated By Chiropractic Care 2Health News:Relief For British MS Patients: Cannabis-Based Oral Spray 2
(Date:12/24/2014)... Trade Commission (ITC) issued its final decision in the case ... issued on December 23, the ITC ruled in favor of ... invalid. BMC President, James Xu called ... the ITC,s decision in this case. This victory for us ... beginning on the key patents in the case. ResMed chose ...
(Date:12/24/2014)... Wis. , Dec. 23, 2014 PuraMed ... marketer of over-the-counter (OTC) medicinal and healthcare products, announced ... of MigraPure® H, a hemp-based, advanced headache relief product, ... dispensaries in Colorado , ... . With the MigraPure H Advanced headache ...
(Date:12/24/2014)...   Synageva BioPharma Corp. (NASDAQ: ... products for rare disorders, today announced validation by ... Authorization Application (MAA) for sebelipase alfa for LAL ... for accelerated assessment, which has the potential to ... The MAA, and the Biologics License Application ...
Breaking Medicine Technology:ITC Final Decision Goes Against ResMed (RMD) Monumental Win for 3B/BMC 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 2PuraMed BioScience Nears Final Stages Needed for Distribution of MigraPure H 3Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 2Synageva BioPharma Announces Sebelipase Alfa Marketing Authorization Application Validated By The EMA 3
Bard Coude-Tip Latex Urethral Catheter, Two Eyes (Tiemann Model)...
Red Latex Bardex I.C. Foley 2-Way Catheter (Council Model)...
The BARDEX I.C. Catheter represents Bard's newest technology in providing protection against NUTI....
Used for injection into urethral strictures, bladder neck contracture, and the bladder wall. Supplied sterile in peel-open packages. Intended for one-time use....
Medicine Products: