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Researchers Identify Sipa 1 Gene, Responsible For Cancer Metastasis

dulates the adhesive properties of cells, consistent with its effect on RAP 1, which is known to affect cell-cell interactions. A series of experiment has shown that RNA Inhibiton of Sipa1 decreased the numbers of pulmonary metastases from a highly metastatic mammary tumor cell line. Conversely, over expression of the FVB allele increased the numbers of pulmonary metastases. Analysis of human tumors also demonstrated that over expression of SIPA1 is associated with metastatic progression.

The results demonstrate that Sipa1, as determined by its overall protein concentration and/or its availability to inactivate RAP1, modulates metastatic progression. Additional studies are required to verify this and to investigate another potential gene close to Sipa 1 that might also contribute to the Mtes1 locus.

Source: Nature Review Cancer.
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