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Researchers Identify New Genetic Risk Factors for Type 2 Diabetes

ult Obesity. Science Express, Published online April 12, 2007) The latest study found that variations in or near the FTO gene are also associated with greater risk of type 2 diabetes, which is likely related to an increased predisposition to obesity.

When the genomes of the Finnish participants were scanned for all 10 diabetes-associated genetic variants, researchers could identify individuals whose genetic profiles placed them at increased risk for type 2 diabetes – including one subset of people who faced a risk four times higher than those at the lowest genetic risk. This "could potentially have value in a personalized preventive medicine program," the researchers wrote.

However, the researchers emphasized that their predictions of disease risk need to be interpreted with caution because the diabetes group in their sample was "enriched" with people who had affected siblings and because the healthy group excluded people who had impaired glucose tolerance or impaired fasting glucose.

Source-Eurekalert/
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