Navigation Links
Researchers Identify Key Step in Cocaine-Induced Heart Enlargement, Sudden Death

Cocaine, in concentrations commonly sold on the street, causes the abnormal buildup of primitive proteins in heart muscle – a process causing heart enlargement that can ultimately lead to sudden death,// report researchers at the University of South Florida College of Medicine and James A. Haley Veterans’ Hospital.

The study was published in the July 2006 issue of the Journal of Cardiovascular Pharmacology.

“This finding is important because cocaine-related deaths most commonly occur in young people between the ages of 18 and 29, many of whom are totally unaware of the drug’s toxic effects,” said Robert Henning, MD, professor of medicine at the USF College of Medicine at the Haley VA Hospital.

Using heart muscle cells from adult rats, Dr. Henning and his colleagues found that cocaine activates the enzyme calmodulin kinase II (CaMK), which increases calcium within the heart muscle cells. The increase in calcium appears to be a key step in prompting the accumulation of primitive fetal proteins not normally found in adult heart muscle cells – a process that causes the muscles cells, and eventually the heart, to enlarge. It also triggers irregular heart rhythms that can cause sudden death.

The researchers also demonstrated that the CaMK inhibitors Nifedipine and KN-62 appear to limit the accumulation of abnormal proteins in heart muscle, suggesting they may be a useful therapy for cardiac hypertrophy, or enlarged heart.

The USF researchers' findings may also have wider implications for other forms of heart enlargement caused by chronic disease. “The biomolecular pathway that we’ve identified likely also plays an important role in heart hypertrophy due to hypertension, heart attacks and heart failure,” Dr. Henning said.

In cardiac hypertrophy, or enlarged heart, the heart’s main pumping chamber becomes abnormally large as a result of an increased workload. In time, fibers of the heart muscle thicken and become less able to relax, reducing the heart’s capacity to meet the body’s demands for normal blood circulation.

Approximately 5 million Americans use cocaine on a regular basis. Cardiac hypertrophy may affect as many as 47 percent of chronic cocaine users with normal blood pressure, Dr. Henning said.

USF Health is a partnership of the colleges of public health, nursing and medicine; the schools of basic biomedical sciences and physical therapy; and the USF Physicians Group. It is a partnership dedicated to the promise of creating a new model of health and health care.



Source-Newsise
SRM
'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... , ... October 12, 2017 , ... IsoComforter, Inc. ( ... announced today the introduction of an innovative new design of the shoulder pad. ... you get maximum comfort while controlling your pain while using cold therapy. By utilizing ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... that we intend to develop to enable prevention of a major side effect ... hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed ...
(Date:10/12/2017)... D.C. (PRWEB) , ... October 12, 2017 , ... Leading ... their peers in Washington, D.C., for the 49th Congress of the International Society ... ., Vice President of the Center for Cancer and Blood Disorders at ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... the nation's first interactive health literacy software tool, and the Cancer Patient Education ... of cancer patient education, today announce a new strategic alliance. , As ...
(Date:10/12/2017)... ... October 12, 2017 , ... Farm Forward joins ... other leading institutions in announcing the launch of the Leadership Circle , ... animals are raised for food. , Founding members of the Leadership Circle also ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Oct. 11, 2017  Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: ... facility in Las Piedras, Puerto Rico ... blades. Following ... facility sustained minor structural damage, temporary loss of power ... have been completed, manufacturing operations have resumed, and the ...
(Date:10/4/2017)... South Korea , Oct. 4, 2017  South ... its next-generation CPR training aide "cprCUBE" on Kickstarter. The ... chest compression during cardiac arrests with better efficiency compared ... It also offers real-time feedback on efficacy of the ... The crowdfunding campaign has a goal to raise $5,000. ...
(Date:10/2/2017)... -- AllianceRx Walgreens Prime, the combined central specialty pharmacy and ... manager Prime Therapeutics LLC (Prime), today officially began the ... of new signage at its headquarters in ... few other company-owned facilities across the country. This also ... whom will begin to see the AllianceRx Walgreens Prime ...
Breaking Medicine Technology: