Navigation Links
Researchers Identify Key Step in Cocaine-Induced Heart Enlargement, Sudden Death

Cocaine, in concentrations commonly sold on the street, causes the abnormal buildup of primitive proteins in heart muscle – a process causing heart enlargement that can ultimately lead to sudden death,// report researchers at the University of South Florida College of Medicine and James A. Haley Veterans’ Hospital.

The study was published in the July 2006 issue of the Journal of Cardiovascular Pharmacology.

“This finding is important because cocaine-related deaths most commonly occur in young people between the ages of 18 and 29, many of whom are totally unaware of the drug’s toxic effects,” said Robert Henning, MD, professor of medicine at the USF College of Medicine at the Haley VA Hospital.

Using heart muscle cells from adult rats, Dr. Henning and his colleagues found that cocaine activates the enzyme calmodulin kinase II (CaMK), which increases calcium within the heart muscle cells. The increase in calcium appears to be a key step in prompting the accumulation of primitive fetal proteins not normally found in adult heart muscle cells – a process that causes the muscles cells, and eventually the heart, to enlarge. It also triggers irregular heart rhythms that can cause sudden death.

The researchers also demonstrated that the CaMK inhibitors Nifedipine and KN-62 appear to limit the accumulation of abnormal proteins in heart muscle, suggesting they may be a useful therapy for cardiac hypertrophy, or enlarged heart.

The USF researchers' findings may also have wider implications for other forms of heart enlargement caused by chronic disease. “The biomolecular pathway that we’ve identified likely also plays an important role in heart hypertrophy due to hypertension, heart attacks and heart failure,” Dr. Henning said.

In cardiac hypertrophy, or enlarged heart, the heart’s main pumping chamber becomes abnormally large as a result of an increased workload. In time, fibers of the heart muscle thicken and become less able to relax, reducing the heart’s capacity to meet the body’s demands for normal blood circulation.

Approximately 5 million Americans use cocaine on a regular basis. Cardiac hypertrophy may affect as many as 47 percent of chronic cocaine users with normal blood pressure, Dr. Henning said.

USF Health is a partnership of the colleges of public health, nursing and medicine; the schools of basic biomedical sciences and physical therapy; and the USF Physicians Group. It is a partnership dedicated to the promise of creating a new model of health and health care.



Source-Newsise
SRM
'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... (PRWEB) , ... June 27, 2016 , ... ... for mental health professionals, announced today its affiliation with Tennessee Counseling Association. ... solutions to the network of the Tennessee Counseling Association, adding exclusive benefits and ...
(Date:6/26/2016)... PLAINSBORO, N.J. (PRWEB) , ... June 27, 2016 , ... ... same sources, yet in many ways they remain in the eye of the beholder, ... Oncology (EBO), a publication of The American Journal of Managed Care. For the full ...
(Date:6/26/2016)... ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is ... a fitness app. The fitness app plans to fix the two major problems leading the ... one size fits all type program , They don’t eliminate all the reasons ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. ... from injury. Recently, he has implemented orthobiologic procedures as a method for treating ... one of the first doctors to perform the treatment. Orthobiologics are substances that ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Research ... World Market for Companion Diagnostic Tests" report to their ... Market for Companion Diagnostics The World Market ... and personalized medicine diagnostics. Market analysis in the report includes ... Test Market (In Vitro Diagnostic Kits) by Region (N. America, ...
(Date:6/24/2016)... 24, 2016  Arkis BioSciences, a leading innovator ... more durable cerebrospinal fluid treatments, today announced it ... funding is led by Innova Memphis, followed by ... private investors.  Arkis, new financing will accelerate the ... market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 2016 Research and Markets has ... by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), ... Parenteral) - Global Forecast to 2021" report to ... The global pharmaceutical excipients market is projected to reach ... 6.1% in the forecast period 2016 to 2021. ...
Breaking Medicine Technology: