( Leishmaniasis or black fever as it is c...)Researchers Hopeful About Vaccine For Leishmaniasis,Health

Leishmaniasis or black fever as it is commonly called, is a tropical disease that kills nearly about 60, 000 people, every year//. We might soon be able to put an end to this deadly killer, say Swiss researchers who claim to have produced a vaccine that would protect humans and animals.

The disease is most commonly seen in Bangladesh, Sudan, India, Nepal, and Brazil. The spleen is the organ to be first affected followed by the bone marrow and liver. Progressively, with worsening of the disease, the immune system is eventually destroyed. It is associated with a significant risk of mortality if left unattended to.

Despite the best efforts of the World Health Organization, no vaccine has been developed so far. The lack of proper available treatment for the disease has made the design of a safe and effective vaccine the utmost priority of the WHO. The currently employed drugs for treatment of leishmaniasis are very expensive and have serious side-effects.

'There are about half a million new cases of visceral leishmaniasis occurring each year. Leishmania-endemic regions have expanded in recent years and Leishmania/HIV co-infection has emerged as an extremely serious, increasingly frequent new disease. Given this situation, a safe, effective vaccine against visceral leishmaniasis would prevent a great deal of suffering and death due to a disease, which, if untreated, is very deadly,' remarked Melinda Henry, Immunisation, vaccines and biologicals expert at the WHO.

Active research is being conducted at the moment to design potential vaccines to combat the disease. The latest carbohydrate-based vaccine, being developed by researchers at the Swiss Federal Institute of Technology (ETH) in Zurich offers a new ray of hope.

Synthetic (artificial) carbohydrates derived from the bacteria or parasite causing the disease is used in the production of the vaccine. It stimulates the infected person’s immune cells to install a
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