Navigation Links
Researchers Have Found the Role of Protein in Accelerating Breast Cancer Progression

Boffins at the Scripps Research Institute have found in animal models just how great a role the protein pleiotrophin (PTN) plays in accelerating breast cancer .

Until this study, the significance of pleiotrophin (PTN) expression in breast cancer had not been clearly established, and boffins are hopeful that the new findings could lead to a better understanding of the molecular pathogenesis of breast cancer and focus attention on PTN and its signalling pathway as possible targets for new cancer therapies.

The study also found that the expression of pleiotrophin activated surrounding cells to remodel the tumour microenvironment, induced tumour angiogenesis, and increased the number of receptors for different markers of aggressive breast cancers.

"Breast cancers progress through stages of increasing malignancy triggered by mutations that promote their growth," said Thomas Deuel, the Scripps Research scientist whose laboratory made the discovery.

"The major finding of our study demonstrates both in vivo and in vitro that inappropriate expression of PTN not only promotes breast cancer progression but that by itself PTN secretion from human breast cancer cells may be sufficient to shift that progression to a more aggressive form of breast cancer," he said.

As a part of the study, three animal models were tested to determine if inappropriate expression of PTN alone was sufficient to induce breast cancer or whether the cytokine cooperates with different pathogenic mechanisms to stimulate breast cancer progression.

The new study identified PTN as one factor that activates stromal cells-cells found in the loose connective tissue-and induces several features of aggressive breast cancer. While the importance of these cancer cell-stromal cell interactions is well established, only limited progress has been made in identifying the factors that cause stromal cells to initiate tumour progression.

"Our breakthrough findings demonstrate that PTN-activated stromal cells are responsible for the ultimate remodelling of extracellular matrix proteins, as well as the release of factors that stimulate the growth of malignant cancer cells," Deuel said.

"We've shown that PTN secreted from breast cancer cells is the key mechanism of stromal cell activation, and that PTN alone is sufficient to stimulate many of the critical signalling pathways that aggressively promote breast cancer progression."

Using genetically modified mouse models, the study found that the inappropriate expression of PTN produced breast cancers of a more aggressive subtype. In those same mouse models, highly malignant cells of scirrhous carcinoma-a hard, fibrous tumour-were found to express very high levels of the mouse mammary tumour virus (MMTV)-Ptn transgene along with increases in collagen, elastin, tumour angiogenesis, and increased size of new blood vessels within the breast cancers-all markers for breast cancer.

"Our study suggests the possibility that PTN expression may account for many of the features of scirrhous carcinoma seen in the breast cancers of these mice," Deuel said.

"Pleiotrophin stimulates new collagen of different subtypes and new elastin synthesis. Collagen fragments are known to stimulate growth of carcinoma cells and to stimulate anti-apoptotic pathways, favouring growth of the carcinoma cells," he added.

Other authors of the study, Secretion of Pleiotrophin Stimulates Breast Cancer Progression Through Remodeling of the Tumor Microenvironment, include Yunchao Chang, Masahiko Zuka, and Pablo Perez-Pinera of The Scripps Research Institute; Aurora Astudillo of the Hospital Universitario Central de Asturias, Oviedo, Spain; Joanne Mortimer of the University of California San Diego; and James R. Berenson of the Institute for Myeloma and Bone Cancer Research, Los Angeles.

The study appears in an advanced online edition of the Proceedings of the National Academy of Sciences.


Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:

(Date:6/26/2016)... ... 26, 2016 , ... Brent Kasmer, a legally blind and certified personal trainer is helping to ... app. The fitness app plans to fix the two major problems leading the fitness industry ... fits all type program , They don’t eliminate all the reasons people quit ...
(Date:6/25/2016)... ... 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to a ... new, often overlooked aspect of head lice: the parasite’s ability to live away from a ... occurrence, but a necessary one in the event that lice have simply gotten out of ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has ... he has implemented orthobiologic procedures as a method for treating his patients. The ... first doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set of ... or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, Serenity ... event. , Trauma sufferers tend to feel a range of emotions, from depression, guilt, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Global law firm Greenberg Traurig, P.A. announced that ... chosen by their peers for this recognition are considered among the top 2 percent ... special honors as members of this year’s Legal Elite Hall of Fame: Miami ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... 24, 2016 According to a ... (Standard Pen Needles, Safety Pen Needles), Needle Length (4mm, ... Hormone), Mode of Purchase (Retail, Non-Retail) - Trends & ... studies the market for the forecast period of 2016 ... 2.81 Billion by 2021 from USD 1.65 Billion in ...
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... 2016 Any dentist who has made an implant ... process. Many of them do not even offer this as ... high laboratory costs involved. And those who ARE able to ... a high cost that the majority of today,s patients would ... Parsa Zadeh , founder of Dental Evolutions Inc. and inventor ...
Breaking Medicine Technology: