Navigation Links
Researchers Find 'Secret Weapon' Used by SARS Virus

In 2003, the highly contagious and often-deadly mystery disease now called SARS emerged explosively out of Southern China. It eventually killed an estimated 916 people// in Asia, Europe, and North and South America—nearly one in ten of those it infected.

When scientists identified the virus that caused this sudden acute respiratory syndrome, they classified it as a coronavirus--a virus family whose other members cause many common colds. But to there was nothing common about the lethality of SARS; clearly, this coronavirus had some nasty tricks up its sleeve.

Now, in a discovery that suggests a possible new route by which scientists might fashion a vaccine against SARS, researchers at the University of Texas Medical Branch at Galveston (UTMB) have uncovered one of those tricks: a 'secret weapon' that the SARS coronavirus uses to sabotage the immune defenses of infected cells. Experiments conducted by the UTMB scientists show that a SARS coronavirus protein called 'nsp1' causes the breakdown of biochemical messages that normally prompt the production of a protein critical to defending the body against viruses.

'The SARS nsp1 protein degrades the messenger RNA instructions sent from DNA to make interferon beta, which is crucial to host immunity,' said UTMB professor of microbiology and immunology Shinji Makino, senior author of a paper on the discovery to be published online the week of August 7 in the Proceedings of the National Academy of Sciences. 'This is a very rare phenomenon, and it raises a lot of questions — among them, whether we can make a mutant form of SARS coronavirus that lacks the ability to degrade messenger RNA, which could ultimately lead to the creation of a live attenuated vaccine for SARS.'

Although many viruses interfere with host cells making messenger RNA or translating it into infection-fighting proteins, only one other virus is known to break down messenger RNA: herpes simplex virus (HSV).

Makino credits lead author Wataru Kamitani, a UTMB postdoctoral research fellow, with noticing that the nsp1 protein had an unexpected effect while he was investigating a different set of SARS coronavirus proteins. 'He found this suppression of host gene expression, and then he designed several elegant experiments that showed it was caused by RNA degradation, something never before seen in an RNA virus.'

Exactly how that degradation takes place, how an RNA virus can preserve its integrity when it makes a protein that breaks down RNA, and whether a mutated non-RNA-degrading SARS coronavirus could constitute a workable SARS vaccine are all issues that Makino's group intends to pursue. 'The main concern for everybody is whether SARS will come back,' Makino said. 'We want to be ready for it if it does.'

(Source: Newswise)
'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/20/2017)... ... September 20, 2017 , ... The Honey Pot ... Vaginas.” The goal is to ignite conversation via social media and word-of-mouth regarding ... brand has declared September “Humans with Vaginas” month, releasing a video celebrating the ...
(Date:9/20/2017)... ... September 20, 2017 , ... Recognising that in today’s busy ... Greeny delivers positive results in just three weeks. Setting the groundwork for a ... Fitting seamlessly into hectic work and family schedules, participants can lose up to ...
(Date:9/20/2017)... ... September 20, 2017 , ... Ron Norman, ... executive marketers this week about the value of senior executives, pointed to a ... happened in business has brought us to the present and will lead us ...
(Date:9/20/2017)... ... ... “Monique”: is the story of Monique, whose mother’s deteriorating physical condition ... Colleen Crispi, has owned four beauty salons and written a book regarding the author’s ... cooking. , “The doctor’s office was only three blocks away, and she could ...
(Date:9/19/2017)... (PRWEB) , ... September 19, 2017 , ... Trusted debt-reduction ... over 175,000 debt accounts, translating to in excess of $835 million in resolved debt ... and other unsecured loans are some of the categories of debt settled by the ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... WASHINGTON , Sept. 8, 2017 ... Mobile MRI Unit coming to Washington DC ... When: Tuesday, September 12 th – Monday, ... to Washington, D.C. offering free MRI brain scans to the public.Where:  ... – will be parked at 501 K Street NW, Washington, D.C.What:BTF brings ...
(Date:9/7/2017)... , Sept. 7, 2017 Caris Life ... on fulfilling the promise of precision medicine, today ... the benefits of its molecular profiling approach in ... comprehensive genomic profiling plus (CGP+) with Caris Molecular ... tumor on a molecular level, leading to more ...
(Date:9/6/2017)... 2017  Medical professionals are expected to ... treating their patients. Medical simulations offer clinicians ... patients. Simulation provides a safe method for ... procedures, refine techniques and build confidence, without ... technology, such as augmented reality, will now ...
Breaking Medicine Technology: