Navigation Links
Researchers Find New Target to Treat Type 2 Diabetes

Scientists have discovered a potential new target, Akt2/PKB, a fat metabolism regulatory protein, and its molecular partner, PGC-1a for the treatment of type 2 diabetes.

The study was conducted by a team of researchers led by Morris J. Birnbaum at the University of Pennsylvania School of Medicine.

When a person eats, insulin is secreted by the pancreas to signal the liver to stop forming glucose and burn fat. However in the case of a type 2 diabetic insulin can only do the later job. This gives the diabetic person a double whammy as fatty acids build up from food as well as from liver resulting in more fat deposition in tissues that increase obesity.

As part of the study, researchers conducted experiments on mice to find a direct link between insulin and fat metabolism control.

Researchers found that the protein Akt2/PKB adds a phosphate group to its molecular partner PGC-1a in the presence of insulin after a meal. It results in blocking the activation of the genes by PGC-1a that are required for fat metabolism.

Muscle and fat tissue also burn fat stores, and we are currently investigating whether PGC-1a and Akt2/PKB have the same role in those tissues, Birnbaum said.

The study also showed that mice that had non-functional Akt2/PKB had low insulin-stimulated phosphorylation of PGC-1a. The researchers showed that excessive PGC-1a or PGC-1a that could not be phosphorylated cause the liver to produce many copies of the fat metabolism genes.

We hope that drug companies will look for new ways to modify fat metabolism in type 2 diabetics using these possible targets, Birnbaum said.

The findings of the study were published in Nature.


'"/>




Page: 1

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/26/2017)... , ... July 26, 2017 , ... Wendy M. Musielak, a partner at ... elected as DuPage County Bar Association’s third Vice President earlier this year. She will serve ... office of the second Vice President, in accordance with the organization’s by-laws. , Musielak ...
(Date:7/26/2017)... ... July 26, 2017 , ... The number of adults 65 years or ... ways to improve asthma control in the population are not well described. In a ... Practice), an official journal of the American Academy of Allergy, Asthma & Immunology (AAAAI), ...
(Date:7/25/2017)... (PRWEB) , ... July 25, 2017 , ... Summers in ... up the air conditioner — think homemade gourmet ice cream, sparkling pools, and mile-high ... gift shop featuring fun mugs, journals, and other must-have knick knacks. Ice cream and ...
(Date:7/25/2017)... ... July 25, 2017 , ... ... launch of their partnership to provide the Pharmacist eCare Plan to ... in the country with the ability to develop the Pharmacist eCare Plan, a ...
(Date:7/25/2017)... D.C. (PRWEB) , ... July 25, 2017 , ... ... and their clients, today announced it will be exhibiting and providing demos of ... at the Walter E. Washington Convention Center in Washington D.C. from August 3-6, ...
Breaking Medicine News(10 mins):
(Date:7/21/2017)... and EDMONTON, Alberta , July ... and the University of Alberta in ... in Nature,s partner journal, Schizophrenia 1 , demonstrating ... instances of schizophrenia with 74% accuracy. This retrospective ... of specific symptoms in schizophrenia patients with significant ...
(Date:7/19/2017)... N.C. , July 19, 2017  Mako Medical ... Affairs, and the Military Family Assistance Fund (MFA) to ... to visit with their families one last ... funding to coordinate the travel and logistics needed for ... our deployed soldiers and their families. We just wish ...
(Date:7/13/2017)...  Centurion Medical Products, a leader in medical product innovation and ... removal device for hospice patient care. ... Centurion Medical Products ... Patient pain management and emotional comfort are part of a ... pain while preventing unneeded emergency department admission due to severe fecal ...
Breaking Medicine Technology: