Navigation Links
Researchers Find New Target to Treat Type 2 Diabetes

Scientists have discovered a potential new target, Akt2/PKB, a fat metabolism regulatory protein, and its molecular partner, PGC-1a for the treatment of type 2 diabetes.

The study was conducted by a team of researchers led by Morris J. Birnbaum at the University of Pennsylvania School of Medicine.

When a person eats, insulin is secreted by the pancreas to signal the liver to stop forming glucose and burn fat. However in the case of a type 2 diabetic insulin can only do the later job. This gives the diabetic person a double whammy as fatty acids build up from food as well as from liver resulting in more fat deposition in tissues that increase obesity.

As part of the study, researchers conducted experiments on mice to find a direct link between insulin and fat metabolism control.

Researchers found that the protein Akt2/PKB adds a phosphate group to its molecular partner PGC-1a in the presence of insulin after a meal. It results in blocking the activation of the genes by PGC-1a that are required for fat metabolism.

Muscle and fat tissue also burn fat stores, and we are currently investigating whether PGC-1a and Akt2/PKB have the same role in those tissues, Birnbaum said.

The study also showed that mice that had non-functional Akt2/PKB had low insulin-stimulated phosphorylation of PGC-1a. The researchers showed that excessive PGC-1a or PGC-1a that could not be phosphorylated cause the liver to produce many copies of the fat metabolism genes.

We hope that drug companies will look for new ways to modify fat metabolism in type 2 diabetics using these possible targets, Birnbaum said.

The findings of the study were published in Nature.


'"/>




Page: 1

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... , ... June 25, 2016 , ... "With 30 hand-drawn ... specific project," said Christina Austin - CEO of Pixel Film Studios. , ProHand ... all within Final Cut Pro X . Simply select a ProHand generator and ...
(Date:6/25/2016)... Oklahoma City, Oklahoma (PRWEB) , ... June 25, ... ... to helping both athletes and non-athletes recover from injury. Recently, he has implemented ... for the Oklahoma City area —Johnson is one of the first doctors to ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Dr. Amanda ... orthodontic treatment. Dr. Cheng has extensive experience with all areas of orthodontics, including ... accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary adjunct to orthodontic treatment. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Collagen Matrix, Inc., ("Collagen Matrix") the driving ... collagen and mineral based medical devices for tissue ... Messer has joined the company as Vice ... growing portfolio of oral surgery, neurosurgery, orthopaedic and ... the Collagen Matrix executive team as an accomplished ...
(Date:6/24/2016)... June 24, 2016 The Academy of Managed ... recommendations that would allow biopharmaceutical companies to more ... that make formulary and coverage decisions, a move that ... new medicines. The recommendations address restrictions in ... on the drug label, a prohibition that hinders decision ...
(Date:6/24/2016)... --  Pulmatrix, Inc ., (NASDAQ: PULM ), ... today that it was added to the Russell Microcap ... set of U.S. and global equity indexes on June ... for Pulmatrix," said Chief Executive Officer Robert Clarke ... in developing drugs for crucial unmet medical needs, and ...
Breaking Medicine Technology: