Navigation Links
Researchers Find New Target for Anti-cancer Drugs

Duke University researchers believe that they have found a new target for anti-cancer drugs, by focusing on the protein activated by the gene instead of concentrating on well-known gene implicated in almost one-third of all cancers.

In experiments with human cells and animal models, the researchers studied the gene known as Ras, which is integral in normal cell growth. When this gene is mutated and becomes overactive, it can lead to the unregulated proliferation of cells that is the hallmark of tumour formation.

The ras gene, known as an oncogene when it is in this mutated state, has been implicated in several different cancers, including those of the pancreas and lungs. To date, efforts at blocking or turning off ras have proven ineffective. Pancreatic cancer has been shown to have the strongest link to the ras oncogene, and it is also one of the hardest cancers to treat, with few patients alive five years after diagnosis, researchers said.

Since it has been so difficult to target the ras gene itself with drugs, we tried to determine if something that ras activates could be a possible target for a drug or therapy, said Christopher Counter, Ph.D., associate professor of pharmacology and cancer biology and senior member of the research team.

We found a specific target that could be susceptible to drugs, and if these findings are proven true in human trials, we could have a new way of treating ras-dependent cancers, Counter added.

The researchers discovered that the overactive ras gene was responsible for above-normal secretion of a factor known as interleukin-6 (IL-6). Scientists know a great deal about IL-6 and its functions in the body, but its link to oncogenic ras was unknown.

In addition to finding that the ras oncogene spurred the production of IL-6, they also found that inhibiting IL-6 production reduced the creation of new blood vessels, which are crucial for the development
'"/>




Page: 1 2

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers Find New Target for Anti cancer Drugs

(Date:12/21/2014)... December 21, 2014 AlignLife of Norton ... need while at the same time helping people get their ... non-profit community-based organization committed to serving those persons in Muskegon ... needs to improve the quality of life. Dr. Michael Rykse ... impact in the local community and he knew he found ...
(Date:12/21/2014)... SCI explores disability in sports ... barriers for disabled athletes with Aaron Scheidies , ... condition called juvenile macular degeneration, where he loses his ... his athletic ambitions to his vision and how he ... pioneer the way for other blind and visually impaired ...
(Date:12/21/2014)... The Oncology Institute of Hope and Innovation hosted their third ... The Hope for the Holidays Toy Drive is a way ... during the holiday season. This year, the toy drive was ... offices. This event continues to be successful year after year. ... managers and assistant managers came out and not only donated ...
(Date:12/20/2014)... 21, 2014 MissyDress, a distinguished special ... prom lovers. The business has drastically cut prices to ... to everyone until Jan. 30, 2015. Many of the ... dresses, V-neck dresses, lace dresses, and more. , A ... there every day. Whether A-line princess prom dresses or ...
(Date:12/20/2014)... 2014 DePuy Pinnacle hip lawsuits ... of the artificial hip system was defectively designed ... courts, Bernstein Liebhard LLP reports. According to an ... Court on December 2nd, counsel in 10 DePuy ... plaintiffs on November 19, 2014, with depositions to ...
Breaking Medicine News(10 mins):Health News:AlignLife of Norton Shores Makes a Brighter Christmas for Kids in Muskegon 2Health News:Disability in Sports on SCI TV with Triathlon World Champ Aaron Scheidies 2Health News:Disability in Sports on SCI TV with Triathlon World Champ Aaron Scheidies 3Health News:MissyDress: The Prices of Prom Dresses Just Reduced 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 3Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 4
... Needs of Life Science Companies, Health Care ProvidersLIBERTYVILLE, ... a leader in digital sales and marketing solutions, ... the nation,s leading provider of online, on-demand prescription ... a wholly owned subsidiary of Physicians Interactive LLC. ...
... Alliance Creates the Nation,s Largest Independent Online Retailer ... Million CustomersNEW YORK, March 24 Sandow Media, ... e-commerce Web site SpaLook.com, and Salu Beauty, parent ... deliver unprecedented scale and reach for beauty product ...
... Gather to Discuss Interactive Patient Care, Patient Engagement ... GetWellNetwork, Inc., the leading provider of ... highly successful conference, GetConnected2009 . ... GetConnected2009 is the industry,s leading annual ...
... Month , HARRISBURG, Pa., April 1 The Department ... for men and women to take steps to prevent ... well as the importance of discussing their sexual health ... are treatable, screening and early diagnosis are essential to ...
... at 5:00 p.m. EDT -- SOUTH SAN FRANCISCO, ... SNSS ) today announced the execution of a ... private placement of up to $43.5 million in a ... convertible preferred stock and common stock warrants, and a ...
... Medical Innovations, Inc. (NYSE: IMA ), a global ... at home through the merger of rapid diagnostics and health ... was elected to the company,s board of directors. Dr. Adashi, ... Care and in the Life Sciences was also appointed to ...
Cached Medicine News:Health News:Physicians Interactive Acquires MedManage Systems 2Health News:Physicians Interactive Acquires MedManage Systems 3Health News:NewBeauty Magazine and SpaLook.com Create Strategic Alliance With Salu Beauty and SkinStore.com 2Health News:NewBeauty Magazine and SpaLook.com Create Strategic Alliance With Salu Beauty and SkinStore.com 3Health News:Innovation and Sharing of Client Successes Highlight GetWellNetwork's GetConnected2009 Conference 2Health News:Innovation and Sharing of Client Successes Highlight GetWellNetwork's GetConnected2009 Conference 3Health News:Innovation and Sharing of Client Successes Highlight GetWellNetwork's GetConnected2009 Conference 4Health News:Pennsylvania Department of Health Urges Greater Awareness of, Testing for Sexually Transmitted Diseases 2Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 2Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 3Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 4Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 5Health News:Sunesis Pharmaceuticals Announces Up To $43.5 Million Financing 6Health News:Eli Y. Adashi, MD, MS, FACOG, Joins Inverness Medical Innovations' Board of Directors 2
(Date:12/17/2014)... Revenue and earnings above the previous year - ... In the past 2013/14 fiscal year (ended 30 September ... 4.287 billion (last year: EUR 4.190 billion) despite unfavorable currency ... million. "Overall, 2013/14 was a successful fiscal year for the ... CEO of Carl Zeiss AG. "Thanks to our broad portfolio ...
(Date:12/17/2014)... , Dec. 17, 2014 With ... (MRI), the MRI market is seeing new growth, ... breast MRI scans account for the majority of ... higher resolution of images, which are creating opportunities for ... (MRI) market is growing at a rate of ...
(Date:12/17/2014)... 17, 2014  ImmunoCellular Therapeutics, Ltd. ("ImmunoCellular") (NYSE ... Trademark Office (USPTO) has issued a key patent ... immunotherapeutic vaccine targeting six tumor antigens that are ... Patent No. 8,871,211, which issued October 28, 2014, ... a dendritic cell composition comprising peptide epitopes of ...
Breaking Medicine Technology:ZEISS Asserts its Position in Difficult Environment 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 2Kalorama: 3T Advancements Bringing New Growth to the MRI Market 3ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2
... 2011 Actavis Group, the international generic pharmaceuticals company, today ... a binding letter of intent (LOI) with QRxPharma Limited (ASX: ... United States.  Under the terms of the ... IR, a patented 3:2 ratio fixed dose combination of morphine ...
...  QRxPharma Limited (ASX: QRX and OTCQX: QRXPY) announced today execution ... for the formation of a strategic partnership to commercialise MoxDuo ... IR is a patented 3:2 ratio fixed dose combination of ... Group, hf a privately held company based in Europe with ...
Cached Medicine Technology:Actavis to Launch Novel Pain Medication in the US 2Actavis to Launch Novel Pain Medication in the US 3QRxPharma Announces Strategic Partnership with Actavis 2QRxPharma Announces Strategic Partnership with Actavis 3QRxPharma Announces Strategic Partnership with Actavis 4QRxPharma Announces Strategic Partnership with Actavis 5
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: