Navigation Links
Researchers Find Estrogen Governs Genes That Affect Aggression

Ohio State University researchers have studied how a naturally occurring chemical in the bodies of mice affects aggressive behaviour in accordance with the length of the daylight they face.

The researchers found that a class of hormones called estrogens increase aggression in the animal during the short days of winter, while the same chemical decreases aggression among male mice, when daylight increases in the summer.

Published online this week in the Proceedings of the National Academy of Sciences, the study is the first studies to show the possible impacts of simple environmental factors, such as the length of daylight, on how genes influence behaviour.

"We found that estrogen has totally opposite effects on behaviour in these mice depending only on how much light they got each day. It is quite a surprising finding," said Brian Trainor, co-author of the study and postdoctoral fellow in psychology and neuroscience at Ohio State University.

The researchers castrated male mice to stop production of testosterone, and then fitted in them implants that controlled their testosterone levels.

Upon treatment with a drug that halts the production of estrogen, it was found that normally aggressive mice became less aggressive when faced limited daylight as in winter. On the other hand, normally docile mice became more aggressive when faced long-day conditions as in summer.

Moving one step further in their research, the researchers identified the mechanisms that may underlie how the length of daylight affects the way estrogen works to either increase or decrease aggression.

They treated one group of mice with an estrogen-like drug that attaches primarily to estrogen receptor alpha, and another group of mice with a different estrogen-like drug that attaches primarily to estrogen receptor beta. The two receptors are like docking stations that send signals from the estrogen molecules into the cells.

It was found that both the alpha-receptor and the beta-receptor played a key role in increasing aggression in short days and decreasing aggression in long days.

In another study, the researchers then injected mice living in winter-like short-day and summer-like long-day conditions with estradiol, a type of estrogen. The injection increased aggression in mice in winter-like short days almost immediately, while it had no noticeable immediate behavioural effect on the mice living in longer day lengths.

Through the string of studies, the researchers came to the conclusion that estrogen increases aggression in short-day mice by working through non-genomic pathways in the brain, but the hormone decreases aggression in long-day mice through genomic pathways.

The researchers say that their findings may have many implications for humans.


'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the ... save lost souls in the Philippines. “The Journey: From the Mountains to the Mission ... of the Bible. She has taught all ages and currently teaches a class of ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest ... its plans to open a flagship location in Covington, LA at 401 N. U.S. ... Go store next to Office Depot in the Holiday Square shopping center. Its location ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, ... post-acute health care, have expanded their existing home health joint venture through an ... has been operating a joint venture home health company with Asante, delivering clinically ...
(Date:10/12/2017)... ... , ... Leading pediatric oncology experts at Children’s National Health System ... of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of the ...
(Date:10/12/2017)... ... , ... In the United States, single-family home owners pay ... York, New Jersey, Massachusetts, Texas, Virginia, Connecticut, and California—the average is $7,000 a ... rates, which contributes to the relatively lower cost of living in places like ...
Breaking Medicine News(10 mins):
(Date:9/22/2017)... , Sept. 22, 2017  As the latest ... Senators Bill Cassidy (R-LA) and Lindsey ... notes that the medical device industry is in an ... device tax, the 2.3% excise tax on medical device ... they also want covered patients, increased visits and hospital ...
(Date:9/18/2017)... , Pa. and KALAMAZOO, Mich. , Sept. ... Penn. , and OptiMed Specialty Pharmacy of ... partnership to offer a strategic hub service that expedites ... highly sought-after personal spirometer, Spiro PD 2.0, and wellness ... A spirometer is a medical device used to measure ...
(Date:9/12/2017)... MOUNTAIN LAKES, N.J. , Sept. 12, 2017  Consumer reviews ... Embrace Hearing as the number one company for hearing ... Oticon™, ReSound™ and fifteen other brands. ... Embrace Hearing Named #1 by Consumers For Hearing Aids ... Embrace Hearing is an online store that ...
Breaking Medicine Technology: