Navigation Links
Researchers Find Estrogen Governs Genes That Affect Aggression

Ohio State University researchers have studied how a naturally occurring chemical in the bodies of mice affects aggressive behaviour in accordance with the length of the daylight they face.

The researchers found that a class of hormones called estrogens increase aggression in the animal during the short days of winter, while the same chemical decreases aggression among male mice, when daylight increases in the summer.

Published online this week in the Proceedings of the National Academy of Sciences, the study is the first studies to show the possible impacts of simple environmental factors, such as the length of daylight, on how genes influence behaviour.

"We found that estrogen has totally opposite effects on behaviour in these mice depending only on how much light they got each day. It is quite a surprising finding," said Brian Trainor, co-author of the study and postdoctoral fellow in psychology and neuroscience at Ohio State University.

The researchers castrated male mice to stop production of testosterone, and then fitted in them implants that controlled their testosterone levels.

Upon treatment with a drug that halts the production of estrogen, it was found that normally aggressive mice became less aggressive when faced limited daylight as in winter. On the other hand, normally docile mice became more aggressive when faced long-day conditions as in summer.

Moving one step further in their research, the researchers identified the mechanisms that may underlie how the length of daylight affects the way estrogen works to either increase or decrease aggression.

They treated one group of mice with an estrogen-like drug that attaches primarily to estrogen receptor alpha, and another group of mice with a different estrogen-like drug that attaches primarily to estrogen receptor beta. The two receptors are like docking stations that send signals from the estrogen molecules into the cells.

It was found that both the alpha-receptor and the beta-receptor played a key role in increasing aggression in short days and decreasing aggression in long days.

In another study, the researchers then injected mice living in winter-like short-day and summer-like long-day conditions with estradiol, a type of estrogen. The injection increased aggression in mice in winter-like short days almost immediately, while it had no noticeable immediate behavioural effect on the mice living in longer day lengths.

Through the string of studies, the researchers came to the conclusion that estrogen increases aggression in short-day mice by working through non-genomic pathways in the brain, but the hormone decreases aggression in long-day mice through genomic pathways.

The researchers say that their findings may have many implications for humans.


'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/5/2016)... ... February 05, 2016 , ... Pivot ... 2015 Best in KLAS: Software & Services for HIT Implementation Support & Staffing ... report independently ranks vendor performance by healthcare executives, managers and clinicians representing over ...
(Date:2/5/2016)... ... ... Dr. Justin Scott and Dr. Lydia Muccioli of Pure Dental Health ... in need. The event is scheduled to take place on February 27, 2016 from ... dental care to community members in need. Each patient will be given the opportunity ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... ... founder of CitiDent, announces that it is now welcoming orthodontist, Dr. Amanda ... CitiDent offers a complete range of oral health care, including general dentistry, cosmetic ...
(Date:2/5/2016)... , ... February 05, 2016 , ... In sleep, when ... as a dream. A hallmark feature of patients with eating disorders is significant self-criticism, ... eating disorder behaviors and obsessions are regarded as maladaptive means for coping with this ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... ... manufactures practical mobile kitchens, recently announced the debut of their latest mobile kitchen ... Mobile Kitchens provides organizations with modern, high-volume commercial kitchens for use anywhere in ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Feb. 4, 2016  The Senior Care Pharmacy ... Reform Committee Chairman Jason Chaffetz (R-UT) ... today,s hearing , "Developments in the Prescription ... and growing questions about abusive pharmacy benefit manager ... (R-UT) and Ranking Member Elijah Cummings (D-MD) are ...
(Date:2/4/2016)... , Feb. 4, 2016 Wegener ... Global Markets Direct,s, ,Wegener Polyangiitis - Pipeline ... Wegener Polyangiitis,s therapeutic pipeline. This report provides ... Polyangiitis, complete with comparative analysis at various stages, ... (MoA), route of administration (RoA) and molecule type, ...
(Date:2/4/2016)... Frontier Pharma: Chronic Obstructive Pulmonary Disease ... Chronic Obstructive Pulmonary Disease (COPD) is ... the airways and lungs. Persistent breathing difficulties and ... one of the leading causes of morbidity and ... COPD is linked to cumulative exposure to risk ...
Breaking Medicine Technology: