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Researchers Explore the Effect of Engineered Immune Cells on HIV

Gene therapy has always excited scientists, even after twenty years of its introduction.// The present goal, however, is to tame the evil ways of viruses, such as those involved in triggering the human immunodeficiency syndrome (HIV). Scientists have realized there is one stumbling block to this goal- which is to make headways towards the development of an effective transport system, equipped to deliver therapeutic payloads to specific cells.

As challenging as the problem has been, researchers in the Viterbi School of Engineering may be turning a corner. With support from a $13.9 million grant from the Bill and Melinda Gates Foundation, a multi-institutional team of scientists, including Pin Wang of the USC Mork Family Department of Chemical Engineering and Materials Science, is exploring a completely new way of manipulating the body's natural defense system.

"Rather than focusing on conventional vaccines that boost the immune system, we are experimenting with a way to help the immune system produce antibodies that can neutralize the virus," says Wang. "If we can design a modified virus that will deliver these antibodies to chosen cells, we will be able to insert DNA that will help rather than harm cells."

Viruses are efficient carriers or transport vehicles in the body because they are naturally able to penetrate cells, inserting the genetic material they contain into their new host. By itself, a virus cannot reproduce; it must infect a cell and take control of the host's machinery to make copies.

HIV also possesses an unusual structure and a keen ability to hide from antibodies in a sugar-coated shield. The shield has very few open spaces on its surface, Wang says, which makes it virtually impossible to puncture. But because the virus also has n uncanny ability to hide, HIV often goes virtually unnoticed by neutralizing antibodies that are roaming the body in search of disease.

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