Navigation Links
Researchers Discovers DNA Repair as Key to Huntington's Disease

Researchers have discovered that a miscue of the body’s genetic repair system may cause Huntington’s disease, a fatal condition that affects 30,000 Americans annually// by destroying their nervous system. Until now, no one knew how Huntington’s begins, only that it is incurable.

"We showed that when single-strand breaks in DNA caused by oxidative lesions were repaired, the Huntington’s gene continued to add extra replacement segments," explains Cynthia McMurray, Ph.D., a Mayo Clinic molecular biologist who led the study team. "Over time, this expansion -- especially in nerve cells -- becomes toxic."

The finding is significant because so little is known about Huntington’s. According to Dr. McMurray, the finding is the first confirmed connection between the DNA repair and progression of the disease. Leaders at the NIH, which sponsored the study, are optimistic the findings will lead to advances.

"As so often happens, basic research on a fundamental biological process -- in this case, enzymes involved in DNA repair -- leads to new insights about how diseases arise and new approaches for treating or preventing them," said NIH Director Elias Zerhouni, M.D.

In their study of transgenic mice that carried the human Huntington’s gene, the researchers noted that the repeated tracts of replacement repair segments seem stable until the animals reach about 4 months of age. After that point -- which represents middle age for a mouse -- the segments expand and continue to do so as the animals age. Researchers also showed that the expansion of the tracts -- an inherited characteristic -- also caused toxicity in cells that cannot expand, such as nerve cells. The result is that cell death acceleration is directly proportional to the additional repeated lengths.

In a further step, the team eliminated a key enzyme (OGG1) related to DNA repair for oxidative lesions and found that it stopped or greatly reduced segment growth. Th
'"/>




Page: 1 2

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researchers Discovers DNA Repair Key Huntington Disease

(Date:11/21/2014)... 2014 (HealthDay News) -- Scientists say they,ve mapped the genome ... a British man,s brain, in hopes it might help others ... in the journal Genome Biology , the tapeworm was ... Chinese ethnicity. "This infection is so rare worldwide and ... diagnosed ... until the worm was pulled out from the ...
(Date:11/21/2014)... 2014 The Ohio Children’s Trust Fund ... Chapter, American Academy of Pediatrics (Ohio AAP, [http://www.ohioaap.org ... to parents and caregivers throughout Ohio. The new contract, ... 2015, provides $75,000 to continue the campaign that originally ... Fund is excited to continue partnering with the Ohio ...
(Date:11/21/2014)... Midway through the research period for the 2015 ... of Health Plans, preliminary data shows volatility in the ... is a comprehensive resource with enrollment data and contact ... 2015 edition will be available in February. ... Division, the company’s exclusive in-house research team, have identified ...
(Date:11/21/2014)... CA (PRWEB) November 21, 2014 ... for the dental practice. It includes everything needed to ... , Procedure Coding with CDT , CDT 2015 codes ... from January 1, 2014 - December 31, 2014. Dental ... procedures and services on dental claims. There are significant ...
(Date:11/21/2014)... 2014 RankingBySEO has announced an online ... reputation of lawyers, and the company has named the ... service for lawyers since it receives queries from lawyers ... big numbers. So far, the company has successfully repaired ... in different parts of the world, and now, it ...
Breaking Medicine News(10 mins):Health News:Ick! Tapeworm Infecting Man's Brain Yields Genetic Secrets 2Health News:Ohio AAP and Ohio Children’s Trust Fund Continue Partnership for Safe Sleep Education Campaign 2Health News:Ohio AAP and Ohio Children’s Trust Fund Continue Partnership for Safe Sleep Education Campaign 3Health News:Data from Atlantic Information Services’s Forthcoming Directory Shows Volatility in U.S. Health Care Market 2Health News:PMIC Announces CDT PLUS! 2015, the Ultimate Coding Reference for Dentists and Oral Surgeons 2Health News:RankingBySEO Announces Lawyer Reputation Management Service 2
... Genetic defect in mitochondria might explain other aspects of ... News) -- New research suggests that muscle weakness in ... genetic defect that,s causing mitochondrial disease, which means the ... it,s possible that the mitochondrial disease may also play ...
... The Barbara Ann Karmanos,Cancer Institute researchers today presented, ... in San Diego, CA, the potential benefits,of Thymoquinone ... black seeds (Nigella,sativa), in treating pancreatic cancer., ... black seeds have been consumed in Asia, Africa ...
... Over 300,healthcare workers at Coastal Communities Hospital voted by ... - West (UHW) in a,secret-ballot election conducted by the ... of other caregivers as a member of UHW gives ... that matter most," said,Ruth Calderon, a Licensed Vocational Nurse ...
... and Childbirth #1,Killer of Women in World Today, ... Motherhood today made public its appeals to the,International Monetary ... health. Citing recent reports that the UN Millennium,Development Goal ... unlikely to,be met in Asia until 2076 and many ...
... April 11 Takeda,Pharmaceutical Company Limited ("Takeda", TSE: ... offer for all outstanding shares of the,common stock ... per share. The tender offer is being made ... Takeda America Holdings,Inc., which is a wholly owned ...
... HAMILTON, Bermuda, April 11 CIFG Holding, Ltd., ... named,David Rockwell Chief Risk Officer with overall responsibility ... At the,same time, CIFG also announced Thierry Dissaux ... for CIFG Europe., "David and Thierry are ...
Cached Medicine News:Health News:Muscle Weakness Found in Some Autistic Children 2Health News:Muscle Weakness Found in Some Autistic Children 3Health News:Karmanos Researchers Report Enhanced Chemosensitivity of Pancreatic Cancer Cells by Black Seed Component 2Health News:Karmanos Researchers Report Enhanced Chemosensitivity of Pancreatic Cancer Cells by Black Seed Component 3Health News:Coastal Communities Hospital Workers Join United Healthcare Workers 2Health News:White Ribbon Alliance Calls for International Monetary Fund and World Bank to Invest in Women's Health 2Health News:Takeda Commences Cash Tender Offer for all Outstanding Shares of Millennium 2Health News:Takeda Commences Cash Tender Offer for all Outstanding Shares of Millennium 3Health News:CIFG Names David Rockwell Chief Risk Officer; Thierry Dissaux to Head European Operations 2
(Date:11/21/2014)... SAN MARCOS, Texas , Nov. 21, 2014 /PRNewswire/ ... industrial hemp containing low THC, announces they are now ... is comparable to Charlotte,s Web type strains grown in ... symptoms from other neurological disorders, such as Parkinson,s, MS, ... waiting for US laws to pass, because imported CBD ...
(Date:11/21/2014)... , Nov. 21, 2014  Abaxis, Inc. (NasdaqGS: ... instruments and consumables for the medical, research, and veterinary ... veterinary and research markets in the United ... stock purchase agreement to acquire 100% of QCR & ... based distribution organization. The transaction closed on November ...
(Date:11/21/2014)... MONTREAL , 21. November 2014 ... hat heute bekannt gegeben, dass ... – EMA) die Kennzeichnung als Orphan-Medizinprodukt ... Produktkandidat des Unternehmens zur Behandlung von ... eine seltene, stark beeinträchtigende genetische Krankheit, ...
Breaking Medicine Technology:New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 2New CBD Oil From Industrial Hemp is Comparable to Charlotte's Web, Legal In All 50 States 3Abaxis Acquires UK-based Distribution Organization 2Abaxis Acquires UK-based Distribution Organization 3Abaxis Acquires UK-based Distribution Organization 4Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 2Clementia Pharmaceuticals erhält EMA-Kennzeichnung als Orphan-Medizin für Palovarotene zur Behandlung von Fibrodysplasia ossificans progressiva 3
... Inc. (NYSE: LDR) announced today that its Board of ... share for the second quarter of fiscal 2012. The dividend will ... on March 9, 2012. About Landauer ... services to determine occupational and environmental radiation exposure and is ...
... BRUSSELS, Feb. 28, 2012 Eli Lilly and Company (NYSE: ... global Innovation Starts Here initiative which supports Lilly,s commitment to ... the world. Two key components of this ... Innovation Fellowship Awards. Through both, Lilly scientists will collaborate with ...
Cached Medicine Technology:Lilly Introduces Global 'Innovation Starts Here' Initiative to Foster Innovation and Quality Science 2Lilly Introduces Global 'Innovation Starts Here' Initiative to Foster Innovation and Quality Science 3Lilly Introduces Global 'Innovation Starts Here' Initiative to Foster Innovation and Quality Science 4Lilly Introduces Global 'Innovation Starts Here' Initiative to Foster Innovation and Quality Science 5
... Medical Records module is designed to ... and increase revenues. It creates and ... effort while it streamlines workflow, controls ... to patient care outcomes. NextGen EMR ...
... of products offers complete electronic medical ... Intuition EMR enables physicians to create ... at the point of care, and ... on documentation and more time on ...
... Misys Healthcare Systems provides specialty-specific EMR ... Because we've worked with physician practices for ... doesn't fit the needs of every organization. ... components. Modules such as orders management ...
... of our leading products. Perhaps it's ... what Compulink first developed over 15 ... leaders in the ophthalmic practice management ... the functionality of a busy Optometric ...
Medicine Products: