Navigation Links
Researchers Discover Two Proteins Involved In Cellular Destruction Of HIV Virus

Scientists at the Ohio State University have discovered a hitherto unknown mechanism by which cells fight against the invasion of the HIV/AIDS virus. //It was found that two proteins that help in the repair of injured DNA also destroy the DNA of the HIV virus, which is vital for its survival once it enters the cell.

The report published in the Proceedings of the National Academy of Sciences says that this discovery might lead to newer treatments targeting the virus. "Our findings identify a new potential drug target, one that involves a natural host defence," said lead researcher Professor Richard Fishel. "HIV treatments that target cellular components should be far less likely to develop resistance." Current treatments involve a battery of drugs, which prevent the virus from replicating itself. But doctors fear that the virus might mutate to develop resistance to this combination therapy. In the current study, it was found that cells with high levels of proteins XPB and XPD has lower levels of HIV provirus in their chromosomes. Before HIV enters the cell its genetic material is in the form of ribonucleic acid or RNA, which gets converted into cDNA once it enters the cell. The researchers at Ohio introduced mutations of the two proteins into cells and found that there were higher levels of HIV provirus in the chromosomes of these cells. Then they exposed the cells infected with HIV to a drug known to destroy cDNA. It was found that the virus was destroyed rapidly in cells with normal XPB and XPD than in those with the mutant proteins. "Overall, our results indicate that these two DNA repair proteins participate in the destruction of HIV cDNA in cells," Professor Fishel said. "This process reduces the pool of HIV cDNA that can integrate into host chromosomes, thereby protecting cells from infection."
'"/>




Page: 1

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Conference and Scientific Sessions in Dallas that it will receive two significant new ... the grants came as PHA marked its 25th anniversary by recognizing patients, medical ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with ... Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a ...
(Date:6/24/2016)... Rhinebeck, NY (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of ... of companies that call for a minimum wage raise to $12 an hour by 2020 ... wage. This will restore the lost value of the minimum wage, assure the wage floor ...
(Date:6/24/2016)... ... June 24, 2016 , ... EB Medicine ... Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The awards honor ... Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , “With this ...
(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & ... (TGIG), has initiated cultivation and processing operations at its production facility, and opened ... , Puradigm is the manufacturer of a complete system of proactive air and ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Dehaier Medical Systems ... "Company"), which develops, markets and sells medical devices and ... , signed a strategic cooperation agreement with Hongyuan Supply ... Supply Chain") on June 20, 2016, to develop Dehaier,s ... strategic cooperation agreement, Dehaier will leverage Hongyuan Supply Chain,s ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... "The World Market for Companion Diagnostic Tests" report to ... World Market for Companion Diagnostics The World ... diagnostic and personalized medicine diagnostics. Market analysis in the report ... Diagnostics Test Market (In Vitro Diagnostic Kits) by Region (N. ...
(Date:6/24/2016)... June 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... innovative inhaled drugs, announced today that it was added ... reconstituted its comprehensive set of U.S. and global ... is an important milestone for Pulmatrix," said Chief Executive ... awareness of our progress in developing drugs for crucial ...
Breaking Medicine Technology: