Navigation Links
Researchers Discover How Cancer Evades the Immune System

A study on various kinds of cancer, conducted by researchers at the University of Southern California, has brought about the discovery of a new method to identify the genetic changes that enable tumours to evade the body's immune system.

The findings, demonstrated in human breast and colorectal cancers, are significant to the field of medicine because they may lead to the advancement of diagnostic tests and treatment for cancers.

"The implication is that once you know the mechanism by which tumours evade the immune system, you can match that tumour to available therapies," said senior author Dr. Alan L. Epstein, Professor of Pathology at USC's Keck School of Medicine.

"First, we find the genetic changes that allow a tumour to defeat the immune system, then we can apply therapies that compensate for these genetic alterations," added the researcher, whose findings have been published in the journal Cell.

Dr. Epstein and his student Rebecca Sadun used real-time PCR (rtPCR), a high-speed gene amplification technique, to screen tumours to identify 14 pro-immunity genes (downplayed by tumours) and 11 anti-immunity genes (promoted by tumours).

The researchers studied the expression of these genes in five mouse tumour models for breast cancer, leukaemia, colon cancer, lung cancer and renal cell carcinoma. When they compared two of these immune signatures with corresponding human tumours thereafter, they found that the immune signatures of each of the human breast cancer cases nearly matched that of mice.

Dr. Epstein says that all cases showed a suppression of CD83 and CD28, two genes that affect activation of immune cells, and over-production of B7-H4, a gene whose protein product inhibits immune activation.

The human colorectal cancers, however, showed variations in their immune signatures, which researchers saw as an indication of the need to understand the signature for each patient's individual cancer.

"I see it as the beginning stages of personalized medicine, where we develop tactics for treating the unique genetic make-up of a specific tumour. It becomes even more necessary when we look at all the immunotherapies that are becoming available or are beginning to emerge from research," Dr. Epstein said.

He also said that the rtPCR technology allowed for a relatively inexpensive and rapid analysis on equipment available at most medical centres.

"For now, we need to better understand the immune signatures for the most common human cancers in order to identify the most important targets for immunotherapy," he said.


'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, ... its affiliation with Tennessee Counseling Association. This new relationship allows TherapySites ... Tennessee Counseling Association, adding exclusive benefits and promotional offers. , "TCA is extremely ...
(Date:6/27/2016)... ... , ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy Eyeglasses, ... the United States and Canada wear eyeglasses. Once considered to be a purely functional ... a fashion statement. Even celebrities use glasses as a way of creating an iconic ...
(Date:6/26/2016)... California (PRWEB) , ... June 26, 2016 , ... Pixel ... Cut Pro X. , "Film editors can give their videos a whole new perspective ... Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels contains over ...
(Date:6/26/2016)... ... June 26, 2016 , ... ... have been diagnosed with endometriosis. These women need a treatment plan to not ... comprehensive approach that can help for preservation of fertility and ultimately achieving a ...
(Date:6/25/2016)... ... 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due to ... a new, often overlooked aspect of head lice: the parasite’s ability to live away from ... common occurrence, but a necessary one in the event that lice have simply gotten out ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... , June 27, 2016  VMS Rehab Systems, Inc. ... will take whatever measures required to build a strong ... which is currently listed on the OTC Markets-pink current ... Chairman and CEO, "We are seeing an anomaly in ... understand, not only by the Company, but shareholders and ...
(Date:6/24/2016)... , June 24, 2016   Bay Area ... Network,s Dean Center for Tick Borne Illness ... and Rehabilitation, MIT Hacking Medicine, University of California, ... today announced the five finalists of Lyme ... disease.  More than 100 scientists, clinicians, researchers, entrepreneurs, ...
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American Respiratory ... testing company, is now able to perform sophisticated lung assessments in ... Medical Technologies , Inc. Patients are no longer ... to ndd,s EasyOne PRO ® , ARL patients like Jeanne R. ... testing done in the comfort of her own home. ...
Breaking Medicine Technology: