Navigation Links
Researchers Devise Safer Way to Dose Lifesaving Heart Drug

Researchers at the University of Illinois at Chicago have taken the dangerous guesswork out of dosing a lifesaving medication for congestive heart failure.//

A new formula developed in the UIC College of Pharmacy will help physicians prescribe the proper amount of the powerful heart drug digoxin. The medication helps an injured or weakened heart to work efficiently, strengthening the force of the heart muscle's contractions and helping to restore a normal, steady heart rhythm.

Digoxin can be difficult to dose, and there is a small cushion between a beneficial and a deadly level of the drug, said Jerry Bauman, interim dean of the UIC College of Pharmacy. Bauman was the lead investigator of a study that was recently published in the Archives of Internal Medicine.

"The therapeutic range for digoxin in heart failure has recently changed to become lower and narrower, and the new range is associated with improved mortality," Bauman said. "However, dosing methods have not been modified to reflect this change. In the study, we sought to develop a new method to determine the initial dose of digoxin in patients with heart failure."

Medical records of adult patients who had a steady state of digoxin concentration in their bloodstream were reviewed for six months. An equation was derived using the patients' blood digoxin level, digoxin dose, kidney function, and ideal body weight.

The new formula was then compared to two older methods frequently used to estimate the initial dose of digoxin, and it was found to be superior. Using the new method, investigators constructed a simple nomogram to help clinicians quickly choose the right dose.

"Because the new therapeutic window of digoxin is associated with improved outcomes, more intensive dosage refinement should be considered," Bauman said. "To this end, we offer new dosing recommendations and a nomogram for determining the initial dose of digoxin in pat ients with heart failure.

"This is a new way to dose an old drug."

Source-Newswise
'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/25/2017)... ... April 25, 2017 , ... As ... contracted partners to help with process innovation in drug formulation and manufacturing. ... along with state-of-the-art analytical equipment in support of their development and manufacturing goals. ...
(Date:4/25/2017)... ... 25, 2017 , ... Somnoware, a leading provider of digital ... module. Using this new feature, sleep physicians can now predict the likelihood of ... airway pressure (CPAP), oral, or other forms of sleep apnea therapy. The Somnoware ...
(Date:4/24/2017)... , ... April 24, 2017 , ... Emmanuel College ... busy nursing professionals advance their careers. Beginning in the fall of 2017, Emmanuel’s program ... degree in as few as 16 months and for as little as $14,528. These ...
(Date:4/24/2017)... Houston, TX (PRWEB) , ... April 24, 2017 , ... ... Holocaust Memorial Museum today to honor the victims of the Holocaust and Nazi persecution, ... remembrance ceremonies at Hadamar and Auschwitz on its CMATH Champions trip to Germany and ...
(Date:4/24/2017)... (PRWEB) , ... April 24, 2017 , ... Sean Fay ... Oxiclean, Space Bag, Sonicare Toothbrush, Juiceman Juicer, and the George Foreman Grill (which sold ... any other marketer in the last 25 years. , Now, due to changes in ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... 2017 Companion animal ... in pets such as canine, avian and feline. ... types such as Attenuated Live Vaccines, Conjugate Vaccines, ... and Recombinant Vaccines. Attenuated live vaccines are derived ... which have been weakend under laboratory conditions. Conjugate ...
(Date:4/18/2017)... Ohio , April 18, 2017  Cardinal Health ... Non-GAAP 1 fiscal 2017 earnings per share (EPS) ... and 2019.  This is in conjunction with this morning,s ... Deep Vein Thrombosis and Nutritional Insufficiency businesses. ... from continuing operations will be at the bottom of ...
(Date:4/18/2017)...  Astute Medical, Inc., developer of biomarkers for better ... at the 2017 National Kidney Foundation (NKF) Spring ... April 22. Physicians will present data on two biomarkers, ... for acute kidney injury (AKI) during the management of ... Elevated levels of TIMP-2 and IGFBP-7 have been ...
Breaking Medicine Technology: