Navigation Links
Researchers Developing New Therapy to Re-activate Silenced Genes

Researchers at the University of Illinois at Chicago and Cornell University are developing a new therapy to re-activate silenced genes in patients who suffer from Neurodegenerative diseases or stroke .

During and after a stroke, certain cellular events take place that lead to the death of brain cells. Compounds that inhibit a group of enzymes called histone deacetylases can modulate gene expression, and in some cases produce cellular proteins that are actually neuroprotective -- they are able to block cell death.

"For the first time, we show which one of the 11 histone deacetylase enzymes might be the best target to achieve cellular neuroprotection," said the study's lead investigator, Alan Kozikowski, professor of medicinal chemistry and pharmacognosy and director of the drug discovery program at UIC.

"This work gives us a good direction to follow in testing histone deacetylase inhibitors in animal models for diseases such as Parkinson's and Huntington's disease, and even stroke," he added.

Stroke can cause permanent neurological damage or even death if not promptly diagnosed and treated. It is the third-leading cause of death and the leading cause of adult disability in the United States.

A great deal of research has gone into developing histone deacetylase inhibitors as novel therapeutics, but the majority of the work has been directed toward cancer, Kozikowski said -- in which case, paradoxically, the compounds are employed to stimulate the death of rapidly multiplying cells.

The molecule known as SAHA recently received approval by the Food and Drug Administration for use in cancer therapy and is the first of the histone deacetylase inhibitors to be marketed.

"The use of histone deacetylase inhibitors in medicine would thus appear to hold tremendous promise," Kozikowski said.

But to be clinically useful, he said, drugs must be designed that are able to discriminate between various forms of histone deacetylase.

Kozikowski said the new findings, performed in collaboration with Dr. Brett Langley at the Burke-Cornell Medical Research Institute in White Plains, N.Y., are significant, and that "other exciting results are on the horizon."

Researchers at the Mayo Clinic have found that other histone deacetylase inhibitors they have designed show promise for pancreatic cancer, while yet another, in work performed at the Walter Reed Army Institute of Research, may be effective against malaria.

"This is a new area of drug discovery for the 22nd century," Kozikowski said.


'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2016)... Angeles, CA (PRWEB) , ... June 23, 2016 , ... ... conducted that may expose a possible link between head and neck cancer in individuals ... participating in the study were evaluated based on whether they had gum disease, brushed ...
(Date:6/23/2016)... Beaumont, TX (PRWEB) , ... June 23, 2016 , ... ... family and business clients throughout Jasper County and the surrounding region, is initiating a ... The charity drive will raise funds earmarked for a scholarship fund that will be ...
(Date:6/23/2016)... ... June 23, 2016 , ... Virginia Beach resident Sean Kelly suffered from depression ... water to find peace and set out to accomplish a personal mission: a solo ... the internet. He came across the story of another special operations veteran, Josh Collins, ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... the 20th International Congress of Parkinson’s Disease and Movement Disorders. This special session ... experts, highlighting the relevance, novelty, and quality of both clinical and basic research ...
(Date:6/23/2016)... ... ... The U.S. Supreme Court decision on immigration has significant consequences for Social Security ... (TSCL) . “President Obama’s executive actions on immigration would have provided long - ... country illegally, even though the newly - issued green cards are only temporary,” says ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
(Date:6/23/2016)... VIEW, Calif. , June 23, 2016 ... a.m. CST on Thursday, July 7, 2016 , , , ... kayla.belcher@frost.com ) , , , , EXPERT PANELISTS:  , ... Nitin Naik; Senior Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa ... The global pharmaceutical industry is witnessing an ...
(Date:6/23/2016)... Pa. , June 23, 2016 The ... in an outpatient dialysis facility.  Treatments are usually 3 ... 6 hours per visit, including travel time, equipment preparation ... a patient, but especially grueling for patients who are ... of a skilled nursing and rehabilitation centers for some ...
Breaking Medicine Technology: