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Researchers Develop Tool to Gauge Quality of Life of Hepatitis B Patients

Chronic hepatitis B affects 350 million worldwide. In a new study, UCLA researchers measured the effect of hepatitis B on patients quality of life beyond just the physical symptoms of the disease and created a new tool to better assess patients overall well-being, which may help clinicians guide treatment. The study appears in the July issue of the journal Hepatology.

Our results revealed that to effectively treat hepatitis B patients, clinicians need to consider the social and psychological impact of the disease, as well as biological functioning, said Dr. Brennan M.R. Spiegel, principal investigator and assistant professor of medicine at the David Geffen School of Medicine at UCLA and the Veterans Affairs Greater Los Angeles Healthcare System.

Hepatitis B is caused by a viral infection that can damage the liver and lead to chronic disease. It is contracted most often through contact with infected blood or bodily fluids.

According to Spiegel, little research had been done previously on quality-of-life issues for the majority of hepatitis B patients those who do not have advanced liver disease or, even rarer, end-stage complications.

In developing the first-of-its-kind assessment tool for patients, researchers reviewed existing literature, conducted a focus group with health experts and interviewed hepatitis patients. They then took the information and developed a patient questionnaire that clinicians could use to measure patients quality of life.

We were shocked to find that for many hepatitis B patients without advanced liver disease, the psychosocial impact of the disease affected their lives more than the physical symptoms, said Spiegel, who is also director of the UCLA/VA Center for Outcomes Research and Education. No one had ever documented this before.

The questionnaire measures quality of life on several levels, including psychological well-being, anxiety, vitality, dise ase stigma, vulnerability and transmissibility.

We hope that this quick questionnaire can become a vital sign taken in the doctors office to help see how the patient is doing, added Spiegel.

Spiegel notes that the questionnaire could also be used in clinical trials to help measure outcomes and also to equip patients with knowledge to help them better select between competing disease management strategies.


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