Navigation Links
Researchers Develop Potent Cancer Killer From Vitamin E Derivative

Researchers have now developed a potent cancer killer based on the finding that alpha tocopheryl succinate or Vitamin E succinate// (derivative of Vitamin E) is capable of inducing death of cancer cells. Infamous for its anti-oxidant properties, many take the substance as a nutritional supplement.

The substance kills cancer cells by causing them to undergo a natural process known as programmed cell death, or apoptosis. Until now, no one knew how the agent caused this to happen.

These findings answer that question and also indicate that the molecule's antitumor activity is separate from its antioxidant effect.

The study, led by researchers with The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC-James), is published in the April 28 issue of the Journal of Biological Chemistry.

‘Our findings could lead to a potent chemopreventive agent that has both strong anticancer and antioxidant properties,’ says principal investigator Ching-Shih Chen, professor of pharmacy and of internal medicine, and a researcher with the OSUCCC-James.

‘Such an agent might help reduce the risk of prostate, colon and other cancers.’

Chen and his collaborators found that vitamin E succinate works by blocking a protein called Bcl-xL. The protein, which is made by healthy cells, is often present at abnormally high levels in cancer cells and protects them from dying when they should.

Using computer modeling, the researchers found that the vitamin E derivative works because it lodges in a groove in the structure of the Bcl-xL protein, disabling it.

However, the vitamin E molecule has a long, coiled, protruding tail that keeps the molecule from fitting tightly, and more effectively, into the groove.

‘Once we identified how the agent and the protein interact, we asked how we could improve that interaction,’ Chen says.

Th e scientists found that a relatively simple process of altering the molecule's structure – basically cutting the tail short – allowed a tighter fit and improved the agent's ability to kill cancer cells by five- to ten-fold in laboratory tests.

‘Overall, out findings are proof of the principle that this drug can kill cancer cells very effectively but does very little damage to healthy cells,’ Chen says.

Chen is also the Lucius A. Wing chair of cancer research and therapy at the OSUCCC-James and the Kimberly professor of pharmacy. Funding from the National Cancer Institute supported this research.


'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/28/2017)... ... March 28, 2017 , ... Calibration, qualification, and the appropriate ... and maintaining GMP and USP compliance. In a new webinar from METTLER TOLEDO ... " these requirements are explained. The challenge is to determine how to ...
(Date:3/28/2017)... ... 2017 , ... Neurotechnology , a provider of high-precision ... tracking products: the new NCheck Cloud Bio Attendance cloud-based service and the updated  ... recognition to enable users to check in and out from anywhere via the ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... plans work, the Self-Funding Success website has recently developed and published an informational ... Plans ” was created based on common inquiries the site’s team of third ...
(Date:3/28/2017)... ... March 28, 2017 , ... A ... achieve the “perfect smile.” The National Association of Dental Laboratories (NADL) is informing ... should be aware of when utilizing dental laboratories and technicians that create these ...
(Date:3/28/2017)... ... March 28, 2017 , ... Public relations pros work hard to ... of business channels. , While many results are clear, much of PR is hard ... , When it comes to measurement, firms should always take an all-inclusive approach that ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... Summary This report provides all the information ... interests and activities since 2010. Description The Partnering Deals ... the partnering activity of one of the world,s leading life ... upon purchase to ensure inclusion of the most up to ... be delivered in PDF format within 1 working day of ...
(Date:3/27/2017)... VANCOUVER, British Columbia , March 27, 2017 /PRNewswire/ ... of Directors has appointed William "Bill" Dubiel as President ... Dubiel was also elected to the Board of Directors ... serve as the Executive Chairman of LightIntegra. ... become LightIntegra,s next President and Chief Executive Officer. We,ve ...
(Date:3/27/2017)... VANCOUVER, British Columbia, March 27, 2017  Sophiris ... "Company" or "Sophiris"), a clinical late-stage biopharmaceutical company ... with urological diseases, today reported fourth quarter and ... highlights. Key Corporate Highlights: ... for Localized Prostate Cancer. During 2016, the Company ...
Breaking Medicine Technology: