Navigation Links
Researchers Develop Mouse Model Of Brain Tumor

A team of researchers, led by Dr. Martine Roussel of the St. Jude Children’s Research Hospital has developed a mouse model of medulloblastoma, the most common malignant brain tumor found in children. //

Basically, medulloblastomas are malignant tumors that are formed by cells which are not yet mature or in other words by poorly developed brain cells. These tumors are usually formed in the second part of the brain called the cerebellum. It may be recalled here that the cerebellum is the seat of judgment in human beings. The cause of medulloblastomas, which are aggressive tumors, is unknown as of now. Researchers are continuing to look at various possibilities including a defective gene.

In the current study, the researchers have developed a mouse model of the tumor itself, which they hope will enable them to understand the genetic nuances of human brain tumor development. In the research paper, the authors allude to the role of cyclin-dependent kinase inhibitor, INK4C in mediating the development of medulloblastoma.

Dr. Roussel and colleagues have shown through the above-mentioned model that Ink4c inactivation collaborates with a mutation in a gene called Patched (Ptc1, a Shh receptor) to trigger the development of this tumor. "Preliminary data suggest that INK4c protein expression is diminished in a significant cohort of human medulloblastomas," says Dr. Roussel, "so the Pediatric Brain Tumor Program at our Institution is now planning to include a comprehensive survey of INK4c status in order to determine its prognostic significance."

The study will appear in the November 15th issue of Genes & Development

Contact: Heather Cosel
Cold Spring Harbor Laboratory

Page: 1

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:

(Date:6/24/2016)... Fla. (PRWEB) , ... June 24, 2016 , ... Global ... Trend magazine’s 2016 Legal Elite. The attorneys chosen by their peers for this recognition ... Florida. , Seven Greenberg Traurig Shareholders received special honors as members of this year’s ...
(Date:6/24/2016)... ... , ... Comfort Keepers® of San Diego, CA is excited to announce they ... to drive cancer patients to and from their cancer treatments. Comfort Keepers provides ... life and ongoing independence. Getting to and from medical treatments is one of ...
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are sharpening their pencils ... an essay contest in which patients and their families pay tribute to a genetic ... 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) this September. ...
(Date:6/24/2016)... ... 24, 2016 , ... The Haute Beauty Network, affiliated with ... as a prominent plastic surgeon and the network’s newest partner. , Dr. ... handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands by ...
(Date:6/24/2016)... ... 24, 2016 , ... Strategic Capital Partners, LLC (SCP) in ... investment capital for emerging technology companies. SCP has delivered investment events and ... more than a million dollars of capital investment for five companies. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... OTTAWA, Ontario , June 27, 2016  VMS ... the Company,s Board will take whatever measures required to ... the Company,s stock which is currently listed on the ... S Wexler, Company Chairman and CEO, "We are seeing ... be difficult to understand, not only by the Company, ...
(Date:6/24/2016)... 2016   Bay Area Lyme Foundation , ... Center for Tick Borne Illness , Harvard Medical ... Hacking Medicine, University of California, Berkeley, and the ... five finalists of Lyme Innovation , the ... 100 scientists, clinicians, researchers, entrepreneurs, and investors from ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June ... -based mobile pulmonary function testing company, is now able to ... devices developed by ndd Medical Technologies , Inc. ... done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ... , can get any needed testing done in the comfort of ...
Breaking Medicine Technology: