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Researchers Beginning to Identify Genetic Culprits of Arthritis

ch may allow us to accurately predict the extent and severity of how the arthritis will develop."

Cook is collaborating with Aaron Stoker, the Robert B. Gordon Arthritis Research Fellow in the MU Comparative Orthopaedic Laboratory (COL) and expert in cartilage gene expression. Using the expertise in the COL and collaborations with researchers from Virtual Scopics, LLC in Rochester, N.Y., Stoker and Cook are determining the extent of abnormal gene expression in the knees of dogs and correlating it to MRI results, a clinically relevant assessment of arthritis.

The implications of determining if a person will have arthritis are enormous. Lifestyle changes could be started before the disease even appears, preventing the mechanical grinding of bone from starting. Physicians could preemptively prescribe pharmaceuticals known to slow cartilage degeneration, and researchers could develop new pharmaceuticals to interrupt the disease process.

(Source: Newswise)
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