Navigation Links
Researchers Beginning to Identify Genetic Culprits of Arthritis

Researchers hope to identify arthritis as early as possible in an effort to reverse its progression.Arthritis affects one in three Americans and is the leading// cause of disability in people over the age of 15, according to the Arthritis Foundation. While doctors have been able to treat the disease and offer tips to avoid it, University of Missouri-Columbia researchers have identified telltale, genetic signs that indicate the early onset of arthritis.

"There's no current cure for arthritis, but that's because we can't diagnose the disease while it is in a stage that is reversible," said James Cook, a professor of veterinary medicine and surgery and the William C. Allen Endowed Scholar for Orthopaedic Research. "While some researchers are looking at various biomarkers in blood and other bodily fluids, we’ve identified 16 genes in the cartilage that may be involved with the onset of the disease."

Arthritis may occur due to injury, overloading of the joint, or genetic and environmental causes. In his current study, Cook is examining dogs that have the disease. While it might take years for humans to develop arthritis, dogs develop the signs and symptoms of the disease at a much faster rate. In his study, Cook uses specific MRI, arthroscopy and biochemical techniques to identity problems associated with arthritis, such as bone and cartilage damage. Then he identifies the genetic changes that correlate with the damage.

"The specific injury that we are studying leads to articular cartilage degradation, or damage to the cartilage in the knee," Cook said. "This degradation is the hallmark of osteoarthritis, and while we can accurately assess clinical changes associated with the degradation of arthritis, we cannot clinically assess the initiating events that occur in the potentially reversible stages of disease. Through our research, we have found specific genes that are expressed in the areas where degradation will subsequently occur, whi ch may allow us to accurately predict the extent and severity of how the arthritis will develop."

Cook is collaborating with Aaron Stoker, the Robert B. Gordon Arthritis Research Fellow in the MU Comparative Orthopaedic Laboratory (COL) and expert in cartilage gene expression. Using the expertise in the COL and collaborations with researchers from Virtual Scopics, LLC in Rochester, N.Y., Stoker and Cook are determining the extent of abnormal gene expression in the knees of dogs and correlating it to MRI results, a clinically relevant assessment of arthritis.

The implications of determining if a person will have arthritis are enormous. Lifestyle changes could be started before the disease even appears, preventing the mechanical grinding of bone from starting. Physicians could preemptively prescribe pharmaceuticals known to slow cartilage degeneration, and researchers could develop new pharmaceuticals to interrupt the disease process.

(Source: Newswise)
'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2016)... ... February 11, 2016 , ... The book, “Computers Should Just Work!”, provides a ... ask your IT consultant before signing a contract and how to spot an incompetent ... companies relying heavily on e-mail and technology, it’s more important than ever to make ...
(Date:2/10/2016)... ... February 10, 2016 , ... President Obama’s ... Advantage organizations to deliver medical services via telehealth, estimated to generate more than ... for such language for many years. Although there is more to be ...
(Date:2/10/2016)... ... 10, 2016 , ... Early this week, Team Iconic at J. Walter Thompson ... as the first global confectionery brand sourced from 100% sustainable cocoa. , The Nestlé ... their product, through activities that focus on better farming, better lives and better cocoa. ...
(Date:2/10/2016)... ... 10, 2016 , ... Western University of Health Sciences and ... developmentally disabled in the Coachella Valley. , The two entities, through an expanded ... Highway 111, Suite 100-B, in Rancho Mirage, California. The new site has 11 ...
(Date:2/10/2016)... ... February 10, 2016 , ... ... (VRI) within Healthcare, recently partnered with Heart City Health Center to ... nearly 23 years, Heart City Health Center has provided the Elkhart community with ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... February 11, 2016 ... the "Molecular Diagnostics Reports Bundle" ... http://www.researchandmarkets.com/research/rp4pg8/molecular ) has announced the addition of ... report to their offering. --> ... announced the addition of the "Molecular ...
(Date:2/10/2016)... SUNNYVALE, Calif. , Feb. 10, 2016 /PRNewswire/ ... Warren Kocmond , formerly Executive Vice President ... the position of President and Chief Operating Officer.  ... been expanded, and now include Global Commercial Operations ... and Customer Service.  Mr. Kocmond will continue to ...
(Date:2/10/2016)... , February 10, 2016 --> --> ... Japan .  --> Japan .  --> A ... With submission, Shire continues to strengthen ... With submission, Shire continues to strengthen its presence ... submission, Shire continues to strengthen its presence ...
Breaking Medicine Technology: