Navigation Links
Researchers Analyzes Risk Between Hodgkin Disease and Heart Attack Mortality

Doctors have long known that patients treated for Hodgkin disease are at an increased risk for heart attacks. Researchers quantify the risk of fatal heart attacks// associated with different types of treatment, and they find that the increased risk persists for at least 25 years after Hodgkin disease treatment.

Hodgkin disease is a type of lymphoma that causes enlargement of lymph nodes, spleen, or other immune tissue. Cardiovascular disease is the second highest cause of death (after second cancers) in long-term survivors of Hodgkin disease, and myocardial infarction, or heart attack, is the most common cause of those cardiovascular deaths. This increased risk is related to the treatments for the disease.

To examine the heart attack mortality risk associated with specific drug treatment regimens and radiation, Anthony J. Swerdlow, D.Sc., of The Institute of Cancer Research in Sutton, United Kingdom, and colleagues studied a cohort of 7,033 patients treated for Hodgkin disease in Britain between 1967 and 2000.

Overall, there were 166 deaths from heart attacks among the patients in the cohort. This was two and a half times the number that would be expected in similar people from the general population in that time period. The increased risk of death from heart attack persisted for at least 25 years after treatment. The extra heart attack mortality risk attributed to treatment was three times higher in males than in females. When they looked at heart attack mortality risk according to treatment, they found that the risk was high among patients who received radiation treatment above the diaphragm, which can include parts of the heart. Among chemotherapy drugs, a class of drugs called anthracyclines carried the highest risk of subsequent death from heart attack. Among people who received neither radiotherapy above the diaphragm nor anthracyclines, the drug vincristine was associated with an increased risk of death from heart attacks.

"The risk of death from myocardial infarction after treatment for Hodgkin disease remains high for at least 25 years," the authors write. "The increased risks are related to [radiotherapy above the diaphragm] but may also be related to anthracycline and vincristine treatment."

"Long-term studies that follow lymphoma survivors for many years, such as the one conducted by Swerdlow and colleagues, are needed to help better understand the processes and factors that worsen heart function, especially now that patients in remission are living to older ages when cardiac disease is common," writes John D. Boice Jr., of the International Epidemiology Institute in Rockville, Md. and the Vanderbilt-Ingram Cancer Center, Nashville, Tenn, in an accompanying editorial. "The effects of treatment for Hodgkin lymphoma appear to be lifelong, and cancer survivors should be monitored for late cardiac abnormalities throughout their lives. The goal of keeping these patients alive has been achieved; the next challenge is to continue to reduce the toxicity of curative treatments and to make long-term survival as disease free has possible, breaking as few hearts as possible along the way."

Source-Eurekalert
'"/>




Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/9/2016)... ... 2016 , ... MEDI+SIGN®, a provider of fully-automated patient monitoring ... for Emergency Departments (ED) has been added to their portfolio. Housed in a ... and with a simplified pallet of information available to the patient, the Digital ...
(Date:12/8/2016)... (PRWEB) , ... December 08, 2016 , ... ... Compensation Research Institute (WCRI) officially opened registration today for its 33rd Annual ... in Boston, MA . , The theme of the conference is “Persistent Challenges ...
(Date:12/8/2016)... ... 2016 , ... CURE Media Group, the nation’s leading digital and print media ... Lung Cancer in efforts to combat lung cancer, announced CURE Media Group President Michael ... Media Group is honored to team up with Upstage Lung Cancer in order to ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... version gives development continuity to its innovative Unified Instance Manager architecture, meeting ... In addition, this new version optimizes the unattended auto-dialing system without agents, ...
(Date:12/8/2016)... Peachtree City, Ga (PRWEB) , ... December 08, ... ... and moving as soon after surgery as possible. With this in mind, SIGVARIS ... vein thrombosis (DVT or blood clot) during bed rest and provide the benefits ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... , Dec. 9, 2016 aTyr Pharma, Inc. (Nasdaq: ... development of Physiocrine-based therapeutics to address severe, rare diseases, today announced ... upcoming BMO Prescriptions for Success Healthcare Conference at the InterContinental Barclay ... December 14, 2016, at 4:20 p.m. ET. About ... ...
(Date:12/9/2016)... , Dec. 9, 2016  Forge Therapeutics, ... AG (Frankfurt Stock Exchange: EVT, TecDAX, ISIN: DE0005664809) ... ,LpxC, for the treatment of bacterial infections including ... been recognized as an attractive antibacterial target for ... lack of suitable chemical starting points has hampered ...
(Date:12/8/2016)... 8, 2016  The global biosurgery market is expected ... forecast period of 2016 to 2021. The market is ... USD 18.21 billion in 2016. The market is primarily ... sports related injuries and spinal problems, increasing clearance of ... effective blood loss management. In this report, ...
Breaking Medicine Technology: