Navigation Links
Researcher Hits Bulls-Eye for Antibiotic Target

the other possibility would be to design a drug to mimic the protein, causing the bacteria to react as if it were starving even when in the presence of a plentiful nutrient supply, Sanders said.

Such a signal exists in almost all living things because most organisms struggle to find food or nutrients and have had to develop a way to avoid starvation, he said.

"Bacteria typically are in an environment lacking nutrients and respond by limiting their reproduction," he said. "And that's a good thing because if they were growing at their maximum rate all the time, within two weeks we would be 20 feet deep in bacteria."

The protein also is of particular interest because it is highly processive, meaning it is efficient in the chemical reaction it initiates. It is able to latch onto its substrate, the substance it uses to fuel its chemical reaction, and to stay tenaciously in place until it has consumed all of the substrate, Sanders said.

Using X-ray crystallography, Sanders was able to show the structure of the E. coli exopolyphosphatase and found the protein had a unique way of achieving its high processivity.

"There is a hole in the protein," he said. "This is extremely rare and provides a physical explanation of why it is so processive. The hole physically encompasses the substrate, keeping it in place, in addition to the usual chemical bonding that keeps it attached. Once the protein attaches to the substrate, it doesn't come off. The protein chews away until it reaches the end of the substrate chain."

Sanders worked with a team to create the first-of-its-kind animated movie showing this process from the point of view of the substrate. The audience follows along as it is pulled through the protein from one side to the next.

"This is the first time this sort of thing has ever been seen, and this is the first movie of its kind," he said. "It elegantly illustrates the physical process of
'"/>




Page: 1 2 3

Related medicine news :

1. Researchers urge caution in using ear tube surgery
2. Researchers Scale to assess the Severity of Epilepsy in Kids
3. Researchers trick Alzheimers Enzyme
4. Researchers find new HIV hiding place
5. New Hair in 15 Days Could Now Be A Possibility Say Researchers
6. Researchers developed world’s smallest toothbrus
7. Researchers discover receptor cells that can cause epilepsy
8. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers
9. Researchers reversed the process of memory loss
10. Researchers Identify Key Gene That May Help Brain Treatment
11. Researchers Discover Protein That Causes Malaria
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Researcher Hits Bulls Eye for Antibiotic Target

(Date:8/29/2014)... famous online supplier of trendy clothes, has unveiled its new ... all these mini outfits are offered at discounted rates, up ... September 14. , The company’s senior spokesman states, “To ... designs, we have listed some of the best-selling items in ... to get high quality, fashionable clothes. Many of our sexy ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 DailyGossip.org publishes ... is an absolutely unique method of curing multiple sclerosis ... program was created by Dr. Gary M. Levin, who ... specialist started to become interested in alternative remedies for ... classical remedies cannot be effective in all cases for ...
(Date:8/29/2014)... Champion boxers Laila Ali and Victor Ortiz are ... annual MDA Show of Strength Telethon this Labor Day ... stations across the country. , Ali, former super ... with Laila Ali," will introduce a performance from American ... Association's nationally broadcast show. , Ortiz will introduce R&B ...
(Date:8/29/2014)... According to a CNN article, entitled Medical Marijuana ... study found that those states who legalized medical marijuana ... in the number of painkiller overdoses seen. By reviewing ... comparing various states with and without legalized medical marijuana, ... a 25% decrease in painkiller prescription overdoses in legalized ...
(Date:8/29/2014)... According to new research presented in a Science Daily article ... Drug Misuse Among Young Adults (8/16), peer pressure should ... it comes to prescription drug abuse. Researchers from Purdue University ... problem which influences misuse of prescription drugs is access to ... to have fun with other using friends. Evidently there is ...
Breaking Medicine News(10 mins):Health News:Cheap Sexy Mini Dresses Added To The Product Line Of Skmen.com 2Health News:New Natural Multiple Sclerosis Treatment Review Reveals Gary M. Levin’s Unique Cure 2Health News:Champion Boxers Fight Back Against Muscle Disease 2Health News:Champion Boxers Fight Back Against Muscle Disease 3Health News:Overdoses on Painkillers Decreased in States With Medical Marijuana 2Health News:Overdoses on Painkillers Decreased in States With Medical Marijuana 3Health News:Peer Pressure Irrelevant in Prescription Drug Abuse for Young Adults 2Health News:Peer Pressure Irrelevant in Prescription Drug Abuse for Young Adults 3
... MA Brandeis psychologist Margie E. Lachman has been awarded ... on Aging to learn more about factors that can ... research will identify modifiable beliefs and behaviors that are ... life. , Many middle-aged and older adults believe that ...
... Lives of Eight Families Living with Autism, NEW ... television premiere of Lauren Thierry,s documentary Autism Every Day,on ... Awareness Day by,the United Nations. The film, which debuted ... day in the lives of eight families,struggling to raise ...
... editors of the Proceedings of the National Academy of ... the 2007 Cozzarelli Prize, an award for papers that ... , The award was established in 2005 as the ... Cozzarelli Prize in 2007 to honor late PNAS Editor-in-Chief ...
... 13 Leading speech,pathologist and autism consultant Valerie ... needs technologies at the "Autism Through,the Lifespan" conference ... "The future is now for an entire generation ... of their lives and becoming young,adults with autism. ...
... Inc. (Pink Sheets: HCFE) has established HEALTHY COFFEE ... distribution of Healthy Coffee,drinks and wellness products through ... About Healthy Coffee USA, Inc., HEALTHY COFFEE ... Coffee by providing an opportunity for the average ...
... With Erectile Dysfunction Are Smokers, NEW YORK, Feb. ... attractiveness, it does the exact opposite when he reaches,the ... recent studies, 60-percent of all men who smoke suffer,from ... more passion. In an effort to dramatically improve upon ...
Cached Medicine News:Health News:Brandeis researcher awarded grant to investigate memory and aging 2Health News:Sundance Channel to Premiere Documentary Autism Every Day on World Autism Awareness Day, April 2nd at 8:00pm et/pt 2Health News:PNAS announces 2007 Cozzarelli Prize recipients 2Health News:A Sneak Peek Into the Special Needs Home of Tomorrow - Renowned Autism Consultant Valerie Herskowitz to Present Latest Findings at 'Autism Through the Lifespan' Conference February 14-17 in Orlando 2Health News:Healthy Coffee International, Inc. Establishes Healthy Coffee USA, Inc. as Its Marketing Arm 2Health News:The Best Way to Stoke Your Valentine's Fire: Don't Light Up 2
(Date:8/29/2014)... Md. , Aug. 29, 2014  United Therapeutics ... the U.S. District Court for the District of ... favor in the company,s case against Sandoz, Inc. regarding ... Peter Sheridan ruled that U.S. Patent No. ... and enjoined Sandoz from marketing its generic product until ...
(Date:8/29/2014)... , Aug. 29, 2014 Diseases largely ... a generation ago are returning. Measles was declared eliminated ... in 2014 as of August 15—the highest incidence in ... public health department declared whooping cough a problem of ... are getting sick and dying from these preventable diseases—in ...
(Date:8/29/2014)... Research and Markets has announced the addition ... report to their offering. Multiple ... in demyelination, axonal transection, and neurodegeneration. The myelin sheath ... immune system, which targets neurons within the central nervous ... which the damage of the myelin sheath causes disruption ...
Breaking Medicine Technology:District Court Decision Received In Remodulin Patent Case 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 2Vaccines at the Crossroads: Outbreaks On the Rise Across America 3Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3
... its wide orifice tip, the Finntip Wide ... suspensions and macromolecules like genomic DNA. This ... cell fragmentation. It is excellent for use ... model, the inside diameter of the orifice ...
300 L, Racked, 96 tips/rack Recommended for 250 and 300 L pipettes....
... Application: Pipette tips in a ... Product features of Autoclavable Racks: ... C, Tips supplied in racks with ... Each row of tips is specifically ...
RNase-free Tips...
Medicine Products: