A Purdue University researcher has opened the door for possible antibiotic treatments for a variety of diseases by determining the structure of a protein that controls the// starvation response of E. coli.
This research is applicable to the treatment of many diseases because that same protein is found in numerous harmful bacteria, including those that cause ulcers, leprosy, food poisoning, whooping cough, meningitis, sexually transmitted diseases, respiratory infections and stomach cancer, said David Sanders, an associate professor of biology. Sanders, who is part of the Markey Center for Structural Biology at Purdue, detailed his research in a paper published in the Aug. 16 issue of the journal Structure.
"This is an important discovery for the field of antibiotics, which was greatly in need of something new," Sanders said. "The antibiotics available today face a challenge of increasing resistance and failure. This research suggests a whole new approach to combat bacterial infections. In addition, this protein is an excellent antibiotic target because it only exists in bacteria and some plants, which means the treatment will only affect the targeted bacterial cells and will be harmless to human cells."
Sanders and his collaborator, Miriam Hasson, studied the structure of exopolyphosphatase, a protein in E. coli bacteria that functions as an enzyme and catalyzes chemical reactions within the bacteria. This enzyme provides the signal for bacteria to enter starvation mode and limit reproduction.
"With the ability to control the use of this signal, we can fool bacteria into thinking they are starving all the time, even when they are not; or we could never allow them to realize that they're starving, and that would kill them as well."
Researchers could design drugs to bind to the protein and keep it from being used by the bacteria, rendering the bacteria unable to react to and survive a lack of nutrient supply;Page: 1 2 3 Related medicine news :1
. Researchers urge caution in using ear tube surgery2
. Researchers Scale to assess the Severity of Epilepsy in Kids3
. Researchers trick Alzheimers Enzyme4
. Researchers find new HIV hiding place5
. New Hair in 15 Days Could Now Be A Possibility Say Researchers 6
. Researchers developed world’s smallest toothbrus7
. Researchers discover receptor cells that can cause epilepsy
. 15 Anti-SARS Drugs Identified By China-Europe Team of Researchers 9
. Researchers reversed the process of memory loss10
. Researchers Identify Key Gene That May Help Brain Treatment 11
. Researchers Discover Protein That Causes Malaria