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Research on Celiac Disease in children

Dr. Philip Butzner has been researching on Celiac Disease from as early as 1981. He defined Celiac Disease(CD) as a permanent intolerance to the ingestion of gluten characterized by inflammatory enteropathy and malabsorption (villus atrophy, crypt hyperplasia, and increased intraepithelial lymphocytes).

The article that was recently published by Dr. Butzner discussed CD & Type I diabetes in children. Dr. Butzner conducted a study to assess IGA-EMA// as a screening test for CD in children with IDDM (Insulin Dependent Diabetes Mellitus, also called Type I Diabetes). The earliest tests that were available for the diagnosis of CD were limited to the biopsy. Then in the mid-80's in Europe and about 1995 in the U.S., serological screening became available. However, the gold standard for diagnosing CD remains the small intestine biopsy. Blood samples from 236 known diabetics (1-18 years in age) were tested for total IGA and IGA-EMA by immunofluorescence. Of the 17 that had positive blood tests, 12 were subsequently diagnosed with CD. This is a prevalence of about 5%, which is far higher than the prevalence of CD in the general population. Also blood screening, particularly IGA-EMA (anti-endomysial antibody), demonstrated an association between CD and IDDM of 1 to 4% whereas it was only 0.02% in the general population. The results indicated that all Type I diabetic children should be screened for CD. He also noted that there was significant risks if diabetes and CD are left untreated, such as delayed puberty, growth failure, osteopenia, osteomalacia, anemia and/or gastrointestinal lymphoma.

Dr. Butzner also discussed the effect of oats on children with CD. He stated that his clinical experience has shown that 40% of celiac children cheat on their GF diets and hence the study on celiac children and oats. The aim of the study was to determine the safety of adding a moderate amount of commercially-available oats to the diet of celiac children. Quaker
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