Navigation Links
Research Studies on Molecular Switches of Gene

A single molecular on switch triggers gene activity that cause effects ranging from learning and memory capabilities to glucose production in the liver was discovered by scientists of St.Jude Childrens Research hospital .

The on switch, a protein called CREB, is a transcription factora molecule that binds to a section of DNA near a gene and triggers that gene to make the specific protein for which it codes. CREB activates genes in response to a molecule called cAMP, which acts as a messenger for a variety of stimuli including hormones and nerve-signaling molecules called neurotransmitters.

The St. Jude team showed that each gene that responds to CREB chooses which co-factors, or helper molecules, CREB uses to activate that gene. This finding adds an important piece to the puzzle of how cells use CREB to activate specific genes in response to cAMP signals.

It also suggests that the current model scientists use to explain how CREB works is too simple, said Paul Brindle, Ph.D., associate member of the Department of Biochemistry at St. Jude. Brindle is senior author of a report on this work that appears in the June 20 issue of The EMBO Journal.

CREB is like a plumber who turns on the water flow in a pipe system by using a certain tool, Brindle said. What we discovered is that the CREB plumber requires different tools to turn on different genes; and that each gene determines which set of co-factor tools from CREBs toolbox it will respond to.

In order to activate a gene, CREB must first get tagged by a molecule called phosphate. CREB then recruits a co-factor called CBP/p300 to the gene by binding to this protein at a site called KIX. Previously, scientists thought that a particular transcription factor uses the same co-factors to activate all its target genes.

The new findings showed that phosphate-tagged CREB binding to CBP/p300 at KIX does not account for most gene activation controlled b y the cAMP messenger molecule. Instead, the binding of CREB to KIX is necessary for only part of the activation of certain target genes; those genes became activated even when KIX was disabled .

Further studies suggested that this KIX-independent mechanism can act on the same gene as the KIX-dependent mechanism; and that each mechanism may or may not contribute equally to activating a specific gene.

This more complex view of how CREB works may help us understand how this single transcription factor can stimulate many different genes, depending on which tissues are using it and which signaling molecule caused cAMP to put CREB to work, Brindle said. It is another clue to how CREB might activate the genes for enzymes that make glucose in the liver, while activating different genes in the brain that are key to learning and forming memories.

A long-term implication of this work is that one day it might be possible to manipulate CREBs co-factors to treat disease. A drug that blocked the specific co-factors CREB needs in the liver to trigger activity of genes that make glucose could reduce blood levels of this sugar in people with diabetes, Brindle said. But at the same time, CREB could continue its other jobs without interruption.


Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Researchers urge caution in using ear tube surgery
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Research of Ritalin
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. A Compilation of recent Diabetes Research articles
9. Research on causes for falling helps develop preventive strategies
10. New standards for Human Research Safety
11. Research on Celiac Disease in children
Post Your Comments:

(Date:10/12/2017)... ... October 12, 2017 , ... ... treating sleep apnea using cutting-edge Oventus O2Vent technology. As many as ... disorder characterized by frequent cessation in breathing. Oral appliances can offer significant relief ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... the demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults ... tested to meet the highest standard. , These products are also: Gluten ...
(Date:10/12/2017)... ... October 12, 2017 , ... The American College of ... Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium in Washington, ... In honor of Morris F. Collen, a pioneer in the field of medical informatics, ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information about the technology: , ... to enable prevention of a major side effect of chemotherapy in children. Cisplatin ... patients. For cisplatin, hearing loss is FDA listed on-label as a dose limiting ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... HMP ... the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare ... City on October 11, 2017. , The annual award competition recognizes editorial and design ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... and NEW YORK , Sept. 27, 2017  DarioHealth ... and big data solutions, today announced that its MyDario product is expected ... local TV listings for when The Dr. Oz Show airs in your ... The nine-time Emmy ... ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 /PRNewswire/ ... and OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... a strategic hub service that expedites and streamlines patient ... spirometer, Spiro PD 2.0, and wellness management services.  ... a medical device used to measure lung function for ...
Breaking Medicine Technology: