Navigation Links
Research Shows Carbon Monoxide Prevents Inflammations

Researchers from the University of Michigan Cardiovascular Center had presented new findings// on the properties of the gas carbon monoxide that can cure inflammations in patients who had undergone organ transplants, strokes, or heart attacks.

In a recent study the scientists had found that inhaling small amounts of carbon monoxide for several weeks after transplant surgery prevented the development of a lethal inflammatory reaction in experimental mice receiving transplanted trachea, or windpipes.

If carbon monoxide therapy works as well in human patients as it does in mice, it could prevent an inflammatory response, called obliterative bronchiolitis, which develops in nearly 50 percent of all patients who receive a lung transplant from an unrelated donor.

Results of the current study were published July 18 in the most recent issue of the Journal of Experimental Medicine (JEM).

The research team had focused on the relationship between carbon monoxide and nitric oxide – two poisonous gases produced by different types of cells in the body. Their research findings suggest that a patient’s chances of living or dying after a lung transplant depend, in large part, on the outcome of an internal power struggle between two enzymes that control cellular production of these gases.

The researchers say that Hmox and carbon monoxide gases are the body’s way of trying to limit tissue inflammation and injury induced by iNOS and nitric oxide during transplant rejection. Their data show that localized CO production provides critical protection against the OB induced by iNOS expression. It’s a balancing mechanism. When Hmox expression goes up, it reduces iNOS expression and suppresses a key-signaling pathway involved in the immune response.

The scientists had studied two types of experimental mice – one group lacked the gene for the Hmox enzyme and was unable to synthesize carbon monoxide. Another group produced unusu ally high levels of Hmox and CO. When the scientists’ transplanted windpipes from one type of mouse into the other, genetic differences between the two strains of mice triggered transplant rejection, inflammation and significant narrowing of the airway in the transplant recipients.

But the scientists discovered they could rescue the mice by having them inhale CO-enriched air (100 ppm) for two weeks after transplantation, or by giving them a drug that induces high levels of Hmox expression.

Source: Newswise

Medindia on Obliterative Bronchiolitis: further information

Obliterative Bronchiolitis: This is a common complication that may arise in patients of lung transfer surgery that occurs when the patient’s immune system rejects the transplanted lung and lets the body’s T cells attack the tissue as a foreign object. This remains the leading cause of death for such patients, as often for these patients re-transplant is not a feasible solution.

Carbon Monoxide: This is a colorless odorless gas that is produced by incomplete combustion of gas, oil, wood, coal etc used in burners, stoves, fuel appliances and open fires. High level of accumulated carbon monoxide due to faulty maintenance or poor installation of the apparatus can cause oxygen displacement in the blood stream to cause major harm to the body.


'"/>




Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Researchers urge caution in using ear tube surgery
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Research of Ritalin
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. A Compilation of recent Diabetes Research articles
9. Research on causes for falling helps develop preventive strategies
10. New standards for Human Research Safety
11. Research on Celiac Disease in children
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/29/2017)... ... ... HealthCareMandA.com will host an important webinar — Home Health & Hospice: Buying, ... of the webinar will also be made available following its live presentation. The webinar ... still popular targets for healthcare investors. This highly fragmented sector bounced back in 2016, ...
(Date:3/29/2017)... (PRWEB) , ... March 29, ... ... suburbs and South Hills of Pittsburgh now have easier access to the ... only by Allegheny Health Network (AHN). Orthopaedic surgeons at Forbes Hospital and ...
(Date:3/29/2017)... ... ... has helped over 1.5 million SharePoint users learn the content management system faster and ... for SharePoint was at the farm level. Enterprises using SharePoint Online in Office 365 ... recently released a modified version of the Help System, VisualSP for Site Collections, which ...
(Date:3/28/2017)... ... March 28, 2017 , ... India’s Chigurupati ... to directly address the resolution to globally reduce the harmful use of alcohol ... of FDA and TTB approved ingredients that when infused into alcohol, renders the ...
(Date:3/28/2017)... ... ... The Thyroid Secret is a specialized 9-part documentary series ... recently launched on March 1, and Dr. Wentz discussed varied benefits and aspects ... Wentz is a licensed pharmacist and a foremost thyroid specialist. After being diagnosed ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... PHOENIX , March 28, 2017  Today, ... Pharmacy released a new white paper to ... use of latex in healthcare. Specifically, there is substantial confusion ... fact, the FDA has urged manufacturers to drop the term ... labels, because of the challenge to ensure a product is ...
(Date:3/28/2017)... ALBANY, New York , March 28, 2017 /PRNewswire/ ... features a largely consolidated vendor landscape, with the top ... and Agilent Technologies accounting for a significant 49% of ... in a recent report. The vendor landscape is intensely ... large share in the overall market. These factors have ...
(Date:3/28/2017)...  Akcea Therapeutics, a subsidiary of Ionis Pharmaceuticals, Inc. (NASDAQ: ... directors: Christopher Gabrieli , ... as chairman of the board of Akcea Therapeutics. ... Forest Laboratories. Sandford D. Smith , ... "We are excited to announce this expansion to our ...
Breaking Medicine Technology: