Navigation Links
Research Reveals Way to Speed Up Treatment of Deadly Malignant Hyperthermia

Park Ridge, Ill. "Every second counts for anesthesia patients afflicted by the often deadly condition known as malignant hyperthermia (MH)." According to research published in the April AANA Journal of the American Association of Nurse Anesthetists, the intravenous administration of life-saving dantrolene sodium (DS) can occur significantly faster thanks to a new method of warming the diluent that is used to prepare the DS for use.

Malignant hyperthermia is a silent, inherited metabolic disorder of the muscle that is triggered by specific inhaled anesthetics or succinylcholine and can result in a severely high body temperature. Affected individuals usually appear normal and have no functional difficulties in everyday life.

However, when these individuals receive anesthesia for surgery or some other procedure, this silent disorder can turn deadly. Treatment with DS, a muscle relaxant that restores a healthy level of calcium in the muscles and reduces high body temperature, prevents mortality when administered properly.

The study, titled "The Icarus Effect: The Influence of Diluent Warming on Dantrolene Sodium Mixing Time," set out to determine the possibility of a more expedient method of warming the diluent in order to mix it with DS, thus saving precious time between the onset of MH and the administration of DS.

It was conducted by Kevin Baker, CRNA, MSNA, staff nurse anesthetist for West End Anesthesia Group at St. Mary's Hospital in Richmond, Va.; Donna Landriscina, CRNA, MSNA, assistant professor and assistant director of education in the Department of Nurse Anesthesia, Virginia Commonwealth University, and staff nurse anesthetist at Virginia Commonwealth University (VCU), Medical Center in Richmond, Va.; Heather Kartcher, RN, BSN, a second year graduate student in the Department of Nurse Anesthesia at VCU; and David Mirkes, RN, BSN, a second year graduate student in the Department of Nurse Anesthesia a t VCU.

The researchers discovered that by warming the DS diluent (sterile water) to 41 degrees Celsius it safely lessoned the mixing time and resulted in faster treatment of patients suffering from MH. Thirty seconds or more could be shaved off the DS preparation process, which normally takes two minutes. To conduct the study, two standard fluid warmers were used that are typically found in hospital rooms around the country.

"Every second counts when treating a patient with malignant hyperthermia," said Donna Landriscina, CRNA, MSNA. "This research indicates that it is possible to administer DS faster, thereby increasing the patient's chances of a successful outcome."

The diagnosis of malignant hyperthermia in a patient requires swift action on the part of the anesthesia provider. The key to effectively controlling an MH crisis is the quick administration of DS. Since its introduction into clinical practice in 1979, DS continues to be the first-line of defense against reducing the MH mortality rate from nearly 80 percent in the 1970s to less than 10 percent today.

"For years, nurse anesthetists have been on the forefront of research that has greatly enhanced anesthesia safety," said Kevin Baker, CRNA, MSNA. "New discoveries of best practices such as this one will benefit patients for decades to come."


'"/>




Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Researchers urge caution in using ear tube surgery
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Research of Ritalin
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. A Compilation of recent Diabetes Research articles
9. Research on causes for falling helps develop preventive strategies
10. New standards for Human Research Safety
11. Research on Celiac Disease in children
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/7/2016)... ... December 07, 2016 , ... ... announce that its fully redesigned website, which launched October 17, 2016, features comprehensive ... responsive design and easy-to-navigate layout. Visitors and patients can discover the latest clinical ...
(Date:12/7/2016)... ... December 07, 2016 , ... Texas Premier ... operations" carried out by unethical locksmith companies and is urging Search Engines to ... According to Texas Premier Locksmith, these fraudulent locksmith services take advantage of consumers ...
(Date:12/7/2016)... ... , ... "ProBrand Flip allows FCPX editors to create unique logo reveals which ... Pixel Film Studios. , ProBrand Flip includes 30 flip book reveal animations. Easily reveal ... a variety of flip book animations. In Addition, users can modify each preset to ...
(Date:12/7/2016)... ... 07, 2016 , ... Maureen McLaughlin, LA.c., a certified acupuncturist, ... of Connecticut (RMACT). McLaughlin brings nearly 20 years of experience with fertility patients ... realize their family building goals. Acupuncture helps fertility patients by supporting ...
(Date:12/7/2016)... , ... December 07, 2016 , ... “Walking With God: ... stories that will inspire the reader to be aware of God's direction in their ... published author, Sanford Smith, retired teacher and active church leader. , Sanford ...
Breaking Medicine News(10 mins):
(Date:12/7/2016)... Boehringer Ingelheim today announced that the ... malignant pleural mesothelioma (MPM) met its primary endpoint ... the 17 th IASLC World Conference on ... showed nintedanib plus pemetrexed/cisplatin demonstrated a meaningful clinical ... significantly improved PFS (9.4 vs 5.7 months). Preliminary ...
(Date:12/7/2016)... , December 7, 2016 Today, Stock-Callers.com ... (NASDAQ: JAZZ ), Anthera Pharmaceuticals Inc. (NASDAQ: ... ), and AveXis Inc. (NASDAQ: AVXS ). From ... fell roughly 37% to reach a level equal to what ... down by approximately 14% for the year, it has still ...
(Date:12/6/2016)... N.Y. , Dec. 6, 2016  Licenders is bringing their ... This new location in Park Slope at 203 13 th ... Brooklyn clientele. "Our goal is to ... treatment plans are designed to get children right back to class ... are 100% all natural and safe for the whole family," Licenders ...
Breaking Medicine Technology: