Navigation Links
Research Reveal A New Angle On Neural Circuits.

Researchers from the Brandeis University in US are offering new insight into how the brain’s neural circuits are actually shaped by experience.//

Research from Brandeis University, which has been published online earlier in the in ‘Nature’, has thrown much needed insights into the probable shaping of the neural circuits by experience. The researchers in the article have provided new evidence towards the mechanisms that affect the ability of the visual cortex to plastically reorganize itself after subsequent periods of visual deprivation.

“Getting our brains to wire up properly requires experience during an early critical period of development, and understanding the mechanisms of this experience-dependent plasticity is critical for understanding human development, its disorders, and for designing strategies that promote optimal cognitive development during early childhood,” explained author and neuroscientist Gina Turrigiano.

Neuroscientists have long known that the brain needs proper sensory stimulation to develop correctly and that experience can induce plastical changes in the functional architecture of sensory cortices. Animals that grow up with one eye covered during a critical period of brain development lose some of their visual acuity and ability to respond to certain visual stimuli. In these experimental conditions, Turrigiano and colleagues explored the visual cortex circuit of young rats by recording electrical activity of neurons and their connections.

“We have found an important and novel mechanism involved in the loss of function of cortical circuits,” said co-author neurophysiologist Arianna Maffei. “While our results directly apply to the loss of visual function secondary to sensory deprivation, they very likely represent a more general strategy for cortical networks to respond to experience.”

The researchers showed that the lasting cortical shutdown induced by visual deprivation at early sta ges of development is the result of a massive increase of cortical inhibition. Specifically, the strength of inhibitory synaptic connections between two types of neurons in the layer receiving the input – the inhibitory fast-spiking basket cells and the excitatory star pyramidal neurons – increased 3-fold.

While it has been historically believed that regulation of excitatory synapses is most critical to the development of neuronal circuitry, and that loss of function is the result of a depression of excitation, this research demonstrates that inhibitory synapses play a critical role in proper network wiring and ultimately in preserving – or disrupting - neuronal function.

“Our data suggest a major revision of thinking about how experience works on our brains," noted Turrigiano. "Instead of targeting exclusively excitatory networks, a major locus of plasticity lies within the inhibitory networks. Our data show that inhibitory networks within the cortex are highly plastic, and that some pathological states arise through inappropriate activation of inhibitory plasticity.”

Sourc: EurekAlert.
'"/>




Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Researchers urge caution in using ear tube surgery
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Research of Ritalin
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. A Compilation of recent Diabetes Research articles
9. Research on causes for falling helps develop preventive strategies
10. New standards for Human Research Safety
11. Research on Celiac Disease in children
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology: