( development has been such a historicall...)Research In A New Direction To Develop Innovative Psychotropic Drugs,Health

development has been such a historically inefficient process," explained Dr. Bryan Roth, Professor of Pharmacology at UNC Chapel Hill and Director of the NIMH Psychoactive Drug Screening Program at the National Institutes of Health. Affective disorders include bipolar, depressive and anxiety disorders.

The group, reviewing over a decade of psychotropic drug-development research from industry, government and academia, identified several factors that have contributed to the slow progress in developing new treatments.

Review of past clinical research highlighted that a "single disease model" of schizophrenia and mood disorders has prevailed. Increasingly, clinicians and researchers have begun to understand that a combination of several key symptom modalities may need to be addressed separately. "Some early studies are suggesting that we are looking at the wrong targets for mood disorders. Until we have treatments that make it into the clinical setting, we won't fully know the usefulness of single target treatments," added Husseini Manji, MD, FRCPC, Chief, NIMH Laboratory of Molecular Pathophysiology.

The most promising new direction for CNS (central nervous system) drug development appears to be focusing on treatments that act on more than one molecular target. "We typically have used the 'silver bullet' approach (currently the prevailing practice in industry) designed to hit one molecular target at a time. This analysis shows that drugs with more complex action (or utilizing more than one drug at a time) have a greater potential for positive treatment outcomes," concluded Roth.

This shift may be most noticeable when addressing schizophrenia, a disease in which psychosis has long prevailed as the dominant symptom. Now, notes Carpenter, additional attention is being paid to other important symptoms that may have a greater impact on long-term functionality, including cognitive impairment and depression in people with schizo
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