Navigation Links
Research Identifies Osteoporosis Controlling Protein

Osteoporosis is a disease that is characterized by a reduction in the bone mass and density increasing the susceptibility to bone deformities// and fractures. It affects approximately 10 million Americans above the age of 50 years. At the Harvard School of Public Health (HSPH), scientists have discovered that the removal of a protein, Schnurri-3 (Shn3) in mice led to a dramatic increase in their overall bone mass. The results may have profound implications in the treatment of osteoporosis. Their study was published in the May 26 edition of the journal, Science.

Osteoporosis has serious health consequences. One-fifth of patients with osteoporosis who fracture their hips will die within a year. As the baby boomer generation gets older, it is predicted that the number of hip fractures may triple by 2020 unless better prevention and treatment for the disease is improved.

The researchers, led by Dallas Jones, a research associate in the Department of Immunology and Infectious Diseases, Marc Wein, an MD, PhD student, and senior author Laurie Glimcher, Professor of Immunology, observed that augmented osteoblast activity, rather than impaired osteoblast activity, was responsible for the elevated bone mass. Osteoblasts are cells that form new bone. Jones, Wein and their colleagues found that Shn3 formed a complex with a protein known as WWP1; together, the pair degrades Runx2, a transcription factor that is the master regulator of osteoblast differentiation, which activates key bone formation genes. By removing Shn3 or WWP1, Runx2 doesnt degrade, which leads to increased bone mass.

The authors believe that targeting Shn3 and WWP1 for drug discovery is an exciting prospect. Glimcher's lab has forged a collaboration with Brandeis University biochemist Greg Petsko to find compounds that inhibit the two proteins, which could lead to new and better treatments for osteoporosis. Though the biggest hurdles of drug discovery lie in the distant futu re, said Petsko, 'as early stage targets go, this looks promising. It just smells like a good target.'

Source: Eurekalert

Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Researchers urge caution in using ear tube surgery
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Research of Ritalin
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. A Compilation of recent Diabetes Research articles
9. Research on causes for falling helps develop preventive strategies
10. New standards for Human Research Safety
11. Research on Celiac Disease in children
Post Your Comments:

(Date:11/26/2015)... Toronto, ON and Cambridge, ON (PRWEB) , ... ... ... announced today the availability of a real-time eReferral system for diagnostic imaging in ... CTs, ultrasounds, X-rays, mammography, BMD and Nuclear Medicine tests directly from their electronic ...
(Date:11/26/2015)... ... November 26, 2015 , ... WorldCare International, Inc., the first ... annual Employee Benefits Conference. The Employee Benefits Conference was hosted by the International ... November 11th, 2015. The conference was held at the Hawaii Convention Center in ...
(Date:11/25/2015)... IN (PRWEB) , ... November 25, 2015 , ... ... water accessible for all, Water For Empowerment ™ attracts volunteers together who ... clean water by empowering women as key stakeholders in the process. The non-profit ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dr. John Pierce, Medical ... more about hair loss treatment with the Capillus272™ Pro laser therapy cap. FDA cleared ... thicker and fuller hair, without the need for surgery, prescription pills, or topical foams. ...
(Date:11/25/2015)... ... 25, 2015 , ... Lakeview Health, a Jacksonville-based drug and ... sobriety and show through pictures what a positive difference it makes. The social ... the hashtag #FacesOfGratitude on their Facebook, Twitter, and Instagram accounts. Short stories ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... 2015  The total global healthcare industry is expected to ... Latin America has the highest projected growth ... Japan ), is second with growth projected at ... increased healthcare expenditure. In 2013-2014, total government funded healthcare was ... 2008-2009 to 41.2% in 2013-2014. In real terms, out of ...
(Date:11/25/2015)... 25, 2015 AAIPharma Services Corp./Cambridge Major ... at least $15.8  Million to expand its laboratories ... . The expansion will provide additional office ... growing demands of the pharmaceutical and biotechnology markets. ... will provide up to 40,000 square feet of ...
(Date:11/25/2015)... Kitov Pharma ceuticals ... biopharmaceutical company focused on the development of therapeutic candidates ... announced the closing of its previously announced underwritten public ... each representing 20 ordinary shares of the Company, and ... and warrants were issued in a fixed combination of ...
Breaking Medicine Technology: