Navigation Links
Research Finds That Nicotine Hastens The Growth Of Lung Cancer

Research from the University of South Florida has reported that nicotine would directly act by speeding the growth of lung cancer.//

They explained in the August issue of the Journal of Clinical Investigation, that tobacco smoke contains many agents that cause cancer, and that nicotine itself isn't one of them but they stated that nicotine promotes the growth of existing cancer cells.

The new study has explained that that nicotine influences a key cancer pathway in cells, which may explain how it speeds up cancer growth. The researchers believe that their results may help in the design of better anti-cancer drugs. Srikumar Chellappan of the University of South Florida, in Tampa, US, who led the study said, “We believe that these components can be targeted for cancer therapy. So we are quite excited about the new therapeutic avenues this study has revealed.”

He further explained that nicotine rather than initiating cancer, seems to make existing cancers more aggressive. It was explained that studies done previously had shown, for example, that breast cancer has an increased likelihood of spreading to the lungs of patients who smoke than those who do not. The researchers have found that blocking the receptors for nicotine on the surface of aggressive cancer cells in a laboratory dish had effectively halted their growth. Chellappan has however stressed that cigarette-smoking can nevertheless trigger the development of cancer.

The researchers have explained that it is not yet known how nicotine makes cancers more aggressive, relatively little is known about how it has this effect. Chellappan and his colleagues, had with the intention of finding the solution fore this question, conducted the research, looking into the specific molecules in cancer cells that interact with nicotine.

The researchers explained that they had exposed human lung cancer cells to an amount of nicotine corresponding the amount present in the bloodstream of a person who tends to smokes one pack of cigarettes a day, which had stimulated the cells to replicate. Examining the cells closely it was revealed that nicotine caused a molecule called Raf-1 to bind to a key protein called Rb, which normally suppresses tumors.

Chellappan explained that this interference with the Rb protein's function could make the cancer spread faster. He further explained that 8 out of 10 tumors that were examined by his group had an abnormally high Raf-1 and Rb interactions. , Explaining that this finding lends further support to this idea, Chellappan said, “One area of active research in our laboratory is to identify agents that can prevent the binding of Raf-1 and Rb,” also adding that, such drugs could probably have a potent anti-cancer activities.
br>
'"/>




Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Researchers urge caution in using ear tube surgery
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Research of Ritalin
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. A Compilation of recent Diabetes Research articles
9. Research on causes for falling helps develop preventive strategies
10. New standards for Human Research Safety
11. Research on Celiac Disease in children
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/26/2016)... (PRWEB) , ... June 27, 2016 , ... Quality metrics ... yet in many ways they remain in the eye of the beholder, according to ... a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal ... personalized through a fitness app. The fitness app plans to fix the two major problems ... offer a one size fits all type program , They don’t eliminate all ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library ... City Observer , brings up a new, often overlooked aspect of head lice: the parasite’s ... for fumigation is not a common occurrence, but a necessary one in the event that ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with operations headquartered in ... . ... ... ... Astellas is ...
(Date:6/23/2016)... 2016  Guerbet announced today that it has been ... Award . One of 12 suppliers to ... its support of Premier members through exceptional local customer ... commitment to lower costs. ... our outstanding customer service from Premier," says Massimo ...
(Date:6/23/2016)... , June 23, 2016 ... "Surgical Procedure Volumes: Global Analysis (United States, China, ... Canada)" report to their offering. ... essential tool for healthcare business planners, provides surgical procedure ... at surgery trends with an in-depth analysis of growth ...
Breaking Medicine Technology: