Navigation Links
Research Explains How Lead Exposure Produces Learning Deficits

A study of young adult rats by researchers provides evidence that explains exactly how exposure to lead during brain development produces// learning deficits.

The study shows that exposure to levels of lead that are similar to those measured in lead-intoxicated children reduce the birth and survival of new neurons (neurogenesis) in the brain. Lead also alters the normal development of newly born neurons in a part of the brain (hippocampus) known to be important for learning and memory.

“There was a dogma in neuroscience that you were born with all the neurons you would ever have, but that thinking has changed dramatically in the last 20 years,” said Tomás R. Guilarte, PhD, senior author of the study and professor of environmental health sciences at the Johns Hopkins Bloomberg School of Public Health. “The exciting idea is that scientists have discovered ways to increase the number of new neurons, and this may facilitate learning in the hippocampus portion of the brain.”

The researchers studied young adult rats, using a group of lead-treated and non-treated (control) rats. When they examined the brains of lead-exposed rats, they found that fewer neurons were born and those neurons that were born survived for a shorter amount of time and had abnormal development.

Guilarte explained that newly born neurons extend processes to form new connections with other neurons in the brain—like branches growing off of a tree limb—which allow learning and memory to take place. The length of the neuronal processes, called dendrites, in lead-exposed rats were shorter and twisted when compared to the long and relatively straight dendrites in neurons found in control rats.

“The fewer connections between neurons found in lead-exposed rats decrease their ability to communicate, which has a major impact on the rat’s ability to learn. Previously, we knew that lead impaired cognitive function, but we didn’t know exactly how,” sa id Guilarte. “Now that we know that lead decreases neurogenesis in the hippocampus and alters the ability of these new neurons to communicate, in future studies we hope to determine if environmental enrichment can reverse these detrimental effects of lead.”

Guilarte has studied lead’s effects at the molecular level on rat brain development for more than a decade. In November 2002, Guilarte and colleagues reported that environmental enrichment that stimulates brain activity can reverse the long-term learning deficits caused by lead poisoning.

Source-Eurealert
SRM
'"/>




Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Researchers urge caution in using ear tube surgery
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Research of Ritalin
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. A Compilation of recent Diabetes Research articles
9. Research on causes for falling helps develop preventive strategies
10. New standards for Human Research Safety
11. Research on Celiac Disease in children
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... ... February 08, 2016 , ... Remember the old saying “rub some ... to Perry A~, author of “Calcium Bentonite Clay” the health benefits of integrating clay ... and detoxifying the body. , A former motivational speaker, Perry A~ has since dedicated ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... ... greater than 50% lower incidence rate of type 2 diabetes in the GrassrootsHealth ... ”It is time to make a change in public health,” states Carole Baggerly, ...
(Date:2/8/2016)... ... ... Guruji Mahendra Kumar Trivedi is offering 3 days of accelerated personal growth ... on February 10th. During this time, people can achieve better health, greater wealth, ... from over 40 different countries as an “ordinary man with an extraordinary gift.” ...
(Date:2/7/2016)... Birmingham, Lake Orion, Clarkston, Metamora, Michigan (PRWEB) , ... February 07, ... ... women on Friday in recognition of National Wear Red Day. National Wear Red ... heart disease and stroke in women. Heart disease and stroke cause 1 in 3 ...
(Date:2/6/2016)... (PRWEB) , ... February 06, 2016 , ... US Sports ... Coaching Conference (YUCC) . This event brings together top non-profit leaders, ultimate organizations, and ... and Girls Ultimate”. Valerio Iani, Bay Area Disc Program Director of Youth and Education, ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... 8, 2016  Dynatronics Corporation (NASDAQ: DYNT ... devices and rehabilitation equipment for the physical therapy, ... Broncos, football team for winning the 2016 World ... Chairman and Chief Executive Officer.  "The Broncos have ... forward to enhancing their athletic achievements with our ...
(Date:2/8/2016)... , February 8, 2016 ... report published by Allied Market Research titled, "World ... and Forecasts, 2014-2020", estimates the world synthetic biology ... synthesis and sequencing technology segment would continue to ... software tools segment, collectively, held around half of ...
(Date:2/5/2016)... OAKS, Calif. , Feb. 5, 2016 Amgen ... 5 th Annual Global Healthcare Conference at 9:15 a.m. ... York City . David W. Meline , executive ... at the conference. Live audio of the presentation can be ... , under Investors. A replay of the webcast will also ...
Breaking Medicine Technology: