Navigation Links
Research Explains How Lead Exposure Produces Learning Deficits

A study of young adult rats by researchers provides evidence that explains exactly how exposure to lead during brain development produces// learning deficits.

The study shows that exposure to levels of lead that are similar to those measured in lead-intoxicated children reduce the birth and survival of new neurons (neurogenesis) in the brain. Lead also alters the normal development of newly born neurons in a part of the brain (hippocampus) known to be important for learning and memory.

“There was a dogma in neuroscience that you were born with all the neurons you would ever have, but that thinking has changed dramatically in the last 20 years,” said Tomás R. Guilarte, PhD, senior author of the study and professor of environmental health sciences at the Johns Hopkins Bloomberg School of Public Health. “The exciting idea is that scientists have discovered ways to increase the number of new neurons, and this may facilitate learning in the hippocampus portion of the brain.”

The researchers studied young adult rats, using a group of lead-treated and non-treated (control) rats. When they examined the brains of lead-exposed rats, they found that fewer neurons were born and those neurons that were born survived for a shorter amount of time and had abnormal development.

Guilarte explained that newly born neurons extend processes to form new connections with other neurons in the brain—like branches growing off of a tree limb—which allow learning and memory to take place. The length of the neuronal processes, called dendrites, in lead-exposed rats were shorter and twisted when compared to the long and relatively straight dendrites in neurons found in control rats.

“The fewer connections between neurons found in lead-exposed rats decrease their ability to communicate, which has a major impact on the rat’s ability to learn. Previously, we knew that lead impaired cognitive function, but we didn’t know exactly how,” sa id Guilarte. “Now that we know that lead decreases neurogenesis in the hippocampus and alters the ability of these new neurons to communicate, in future studies we hope to determine if environmental enrichment can reverse these detrimental effects of lead.”

Guilarte has studied lead’s effects at the molecular level on rat brain development for more than a decade. In November 2002, Guilarte and colleagues reported that environmental enrichment that stimulates brain activity can reverse the long-term learning deficits caused by lead poisoning.

Source-Eurealert
SRM
'"/>




Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Researchers urge caution in using ear tube surgery
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Research of Ritalin
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. A Compilation of recent Diabetes Research articles
9. Research on causes for falling helps develop preventive strategies
10. New standards for Human Research Safety
11. Research on Celiac Disease in children
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2016)... ... June 25, 2016 , ... Experts from ... at AcademyHealth’s Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center ... care topics including advance care planning, healthcare costs and patient and family engagement. ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... "With 30 ... their specific project," said Christina Austin - CEO of Pixel Film Studios. , ... and all within Final Cut Pro X . Simply select a ProHand generator ...
(Date:6/25/2016)... ... 25, 2016 , ... Dr. Calvin Johnson has dedicated his ... implemented orthobiologic procedures as a method for treating his patients. The procedure is ... to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to help ...
(Date:6/24/2016)... ... 2016 , ... A recent article published June 14 on E ... goes on to state that individuals are now more comfortable seeking to undergo not ... as calf and cheek reduction. The Los Angeles area medical group, Beverly Hills Physicians ...
(Date:6/24/2016)... ... ... Marcy was in a crisis. Her son James, eight, was out of control. Prone to ... , “When something upset him, he couldn’t control his emotions,” remembers Marcy. “If there ... my other children and say he was going to kill them. If we were ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Ill. , June 23, 2016  In a startling report ... are failing their residents by lacking a comprehensive, proven plan to ... a definitive ranking of how states are tackling the worst ... to only four states – Kentucky , ... Vermont . Of the 28 failing states, three ...
(Date:6/23/2016)... Bracket , a leading clinical trial technology and specialty ... Bracket eCOA (SM) 6.0, at the 52 nd ... in Philadelphia , Pennsylvania.  A demonstration of ... its kind to fully integrate with RTSM, will be held ... a flexible platform for electronic clinical outcomes assessments that is ...
(Date:6/23/2016)...  Guerbet announced today that it has been named ... . One of 12 suppliers to receive ... support of Premier members through exceptional local customer service ... to lower costs. ... outstanding customer service from Premier," says Massimo Carrara ...
Breaking Medicine Technology: