Navigation Links
Research Explains How Lead Exposure Produces Learning Deficits

A study of young adult rats by researchers provides evidence that explains exactly how exposure to lead during brain development produces// learning deficits.

The study shows that exposure to levels of lead that are similar to those measured in lead-intoxicated children reduce the birth and survival of new neurons (neurogenesis) in the brain. Lead also alters the normal development of newly born neurons in a part of the brain (hippocampus) known to be important for learning and memory.

“There was a dogma in neuroscience that you were born with all the neurons you would ever have, but that thinking has changed dramatically in the last 20 years,” said Tomás R. Guilarte, PhD, senior author of the study and professor of environmental health sciences at the Johns Hopkins Bloomberg School of Public Health. “The exciting idea is that scientists have discovered ways to increase the number of new neurons, and this may facilitate learning in the hippocampus portion of the brain.”

The researchers studied young adult rats, using a group of lead-treated and non-treated (control) rats. When they examined the brains of lead-exposed rats, they found that fewer neurons were born and those neurons that were born survived for a shorter amount of time and had abnormal development.

Guilarte explained that newly born neurons extend processes to form new connections with other neurons in the brain—like branches growing off of a tree limb—which allow learning and memory to take place. The length of the neuronal processes, called dendrites, in lead-exposed rats were shorter and twisted when compared to the long and relatively straight dendrites in neurons found in control rats.

“The fewer connections between neurons found in lead-exposed rats decrease their ability to communicate, which has a major impact on the rat’s ability to learn. Previously, we knew that lead impaired cognitive function, but we didn’t know exactly how,” sa id Guilarte. “Now that we know that lead decreases neurogenesis in the hippocampus and alters the ability of these new neurons to communicate, in future studies we hope to determine if environmental enrichment can reverse these detrimental effects of lead.”

Guilarte has studied lead’s effects at the molecular level on rat brain development for more than a decade. In November 2002, Guilarte and colleagues reported that environmental enrichment that stimulates brain activity can reverse the long-term learning deficits caused by lead poisoning.


Related medicine news :

1. Kidney Stones - Interesting New Research implicates bacteria as its cause
2. Researchers urge caution in using ear tube surgery
3. Paracetamol May Cause Live Damage Warns Consumer Education and Research Centre
4. Researchers Scale to assess the Severity of Epilepsy in Kids
5. Research of Ritalin
6. Researchers trick Alzheimers Enzyme
7. Researchers find new HIV hiding place
8. A Compilation of recent Diabetes Research articles
9. Research on causes for falling helps develop preventive strategies
10. New standards for Human Research Safety
11. Research on Celiac Disease in children
Post Your Comments:

(Date:10/12/2015)... ... 2015 , ... The American Society of Clinical Hypnosis (ASCH) ... and clinical training in a health care discipline. , Many practitioners claim ... losing weight, managing pain, or stopping smoking, etc. Frequently, extravagant statements and guarantees ...
(Date:10/12/2015)... ... October 12, 2015 , ... AcousticSheep LLC, creators of ... in honor of Breast Cancer Awareness Month. During the month of October, ... a SleepPhones® Classic product to a breast cancer patient at the Cleveland Clinic. ...
(Date:10/12/2015)... ... October 12, 2015 , ... To help ... its charitable donation to the National Breast Cancer Foundation. The National Breast Cancer ... breast cancer through early detection, education, and support services. , The annual campaign ...
(Date:10/12/2015)... ... October 12, 2015 , ... NFL football fans who are interested in having an opportunity to ... CLICK HERE to donate to Smile for a Lifetime (S4L) Foundation and gift ... all-inclusive trip to the 2016 NFL Super Bowl! , Donors contributing $20.00 or more between ...
(Date:10/12/2015)... , ... October 12, 2015 , ... The translation for ... seamless migration of complete ARIS installations into the Microsoft world. The ARIS models ... As Microsoft Visio® is very familiar for both IT and Office users it is ...
Breaking Medicine News(10 mins):
(Date:10/12/2015)... October 12, 2015 ... to grow at 7.2% CAGR, microscopy market ... rising focus on nanotechnology, technological advancements, and ... report available with ... . --> Complete report on ...
(Date:10/12/2015)...   Royal Philips (NYSE: PHG, AEX: PHIA), ... a collaboration with Genomic Health , Inc. (NASDAQ: ... diagnostic tests, to leverage Philips digital pathology tools in ... testing processes.    --> ... samples and plays a crucial role in the diagnosis ...
(Date:10/12/2015)... , Oct. 12, 2015 Indivior PLC (LON: ... District of Delaware granted the Company,s ... Pharmaceuticals, Abbreviated New Drug Application (ANDA) No. 205299 to market ... (buprenorphine and naloxone) Sublingual Film (CIII) in the ... --> Since August 2013, Indivior has received Paragraph IV ...
Breaking Medicine Technology: