Navigation Links
Rescuing Injured Hearts by Enhancing Regeneration

only the p38 MAP kinase inhibitor had increased proliferation of cardiomyocytes, but no longer had improved heart function at three months. Those receiving only FGF1 maintained their functional improvement, but did not show as much cell proliferation as those receiving the p38 MAP kinase inhibitor. Rats receiving both agents had the greatest improvements in both cell proliferation and heart function.

The findings suggest that getting cardiomyocytes to replicate is not enough to rescue heart function, but that angiogenesis is also needed, Engel says.

“Regeneration is not just making more cardiomyocytes,” he says. “Cardiomyocytes need a blood supply and oxygen to survive. FGF1 did not have a great effect on cell proliferation, but we found it was providing a new blood supply. If you just inhibit p38 MAP kinase, you don’t get blood vessels.”

Two important steps are needed to turn these findings into a treatment, Engel says. First is to show that the treatment works when not given immediately after the heart attack, since many people sustain progressive damage to their hearts from repeated minor infarctions. In this study, rats were treated soon after injury.

Second is the need to develop a safe delivery method. Because FGF1 stimulates angiogenesis, it has the potential for serious side effects if it goes to places other than the heart, possibly promoting tumor growth, for example. And the p38 MAP kinase inhibitor has been shown to damage the liver.

“Every treatment trying to induce proliferation of cardiomyocytes also carries a risk of inducing tumor growth, and thus you have to limit the time and location of treatment,” Engel adds.

One possibility is to inject smaller doses of the agents into the damaged area of the heart in gel form, or instill them through a catheter, so that they would remain in the heart and be released slowly over time. Engel and colleagues recently reported another compound
'"/>




Page: 1 2 3

Related medicine news :

1. Stem Cell Therapy Shows Promise for Rescuing Deteriorating Vision
2. Stem Cell Therapy Shows Promise for Rescuing Deteriorating Vision
3. Mobilizing Stem Cells at the Injured Site Using Hyperbaric Oxygen Treatments.
4. Guidelines For Treating Severely Injured Patients On The Anvil
5. Engineered Tissue Implants benefited Knee Injured patients
6. A Realistic Arm on the Anvil for Injured Soldiers
7. Vitamin E supports Female Hearts
8. Reconstituted Blood Better For Young Hearts
9. A Call To Open Up The Channel Of Goodwill To Rescue The Dying Hearts
10. Surgeons in India to Mend ‘Pakistani Hearts’ by treating 70 Childrn
11. Novel Biological Pacemaker Under Construction for Weak Hearts

Post Your Comments:
(Date:12/4/2009)... -- Medithrive, Inc. has won the Patient,s Choice ...a by popular vote conducted by the online website,...operation, the SF Bay community has selected Medit...icinal marijuana. ,, The rapid rise and popul...sary which caters to the consumer, provides a beau...
(Date:12/4/2009)...re/ -- The large, two-day free health clinic spons...NAFC) in Kansas City on Wednesday and Thursday is ...ninsured and has not seen a doctor recently. All p...entive primary care. ,, "Many people who atten...is fall in Houston, New Orleans and Little Rock fo...
(Date:12/4/2009)...wswire/ -- In response to the U.S. Justice Depart...n of boldione, desoxymethyltestosterone, and 19-no...", under the Controlled Substances Act (CSA), John...oducts Association (NPA), the oldest and largest ...acturers of dietary supplements and other natural ...
(Date:12/4/2009)...from the School of Medicine,s Department of Nutrit...h products of lipid peroxidation and some drugs of...The pathways were identified by a combination of m...ings shed new light on the mechanism of action of ...n as "the date rape drug." The manuscript publishe...
(Date:12/4/2009)...y or 3 weeks later, study shows , , FRID...repair or reconstruction of multiple-ligament knee...udy has found. , Multiple-ligament knee injurie... occur in high-impact car crashes or in certain sp...r these injuries hasn,t been definitively establis...
Breaking Medicine News(10 mins):Health News:Free Health Clinic Event Is Not Just for the Sick 2Health News:Natural Products Association Issues Statement on DEA's Steroid Classification Action 2Health News:Case Western Reserve researchers' new pathway discovery published as 'Paper of the Week' 2Health News:Timing of Multiple-Ligament Knee Surgery May Not Matter 2
...dinburgh Royal Infirmary's accident and emergency ...where else in Scotland to be seen by a doctor.// ...ospital chiefs who face mounting criticism over cl...at more than a third of patients attending A&E spe...
...he rate of people admitted into hospitals with dia...new report by the Australian Institute of Health a...n O'Brien, says that the study shows that between ...diabetes, it is increasing in the community and so...
...he latest study by the UC Davis researchers states...crease their nutrition values by choosing better a...vis team, which is being published in the Septembe...es that need to be changed in order to improve the...
...eports have shown that the number of people dying ... pledge by the government 2002 to reduce the death...stics now show that deaths from heroin, cocaine an... concentrating on the wrong policy-making issues. ...
...ccording to the findings of a UCSF study to be pub..."Obstetrics and Gynecology," the risk of miscarria...est to identify genetic // or chromosomal abnormal...ed during the first and second trimester of pregna...
...oston: U.S. scientists at Harvard Medical School's...out a visual device that may prove a boon// to peo...o gauge the success rate of the high-tech device, ...h comprises of a small camera, pocket-sized comput...
Other Medicine News:Health News:Inordinately Long Waiting Times at A&E Infirmary 2Health News:Kids From Low-Income Groups Could Enhance Their Nutrition By Choosing Better After School Snacks 2Health News:Kids From Low-Income Groups Could Enhance Their Nutrition By Choosing Better After School Snacks 3Health News:Despite The Governments Vow Drug Death Rates On The Rise In UK 2Health News:Prenatal Test and Miscarriage 2Health News:Prenatal Test and Miscarriage 3
(Date:12/4/2009)...ewswire-FirstCall/ -- Watson Pharmaceuticals, Inc....ceutical company, today confirmed that its subsidi...bbreviated New Drug Application (ANDA) with the U....o market its 8mg ramelteon tablets prior to the ex...l Company Limited. Watson,s 8mg ramelteon tablet ...
(Date:12/4/2009)...wswire-FirstCall/ -- AstraZeneca (NYSE: AZN ) to...tion (FDA) has approved once-daily SEROQUEL XR...as adjunctive (add-on) treatment to antidepressant...SEROQUEL XR is the only medication in its class ap...isorder as adjunctive therapy and acute depressive...
(Date:12/3/2009)... COLLEGE, Pa., Dec. 3 Ambry Geneti... an agreement to provide extended bioinformatics g...ware for next-generation sequencing projects perfo....com/cgi-bin/prnh/20090428/LA06744LOGO ) ,, Anj...Ambry has been providing genomics solutions on Ill...
Breaking Medicine Technology:Watson Files FDA Application for Generic Rozerem(R) 2Watson Files FDA Application for Generic Rozerem(R) 3US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 2US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 3US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 4US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 5US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 6US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 7US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 8US FDA Approves SEROQUEL XR(R) For Add-On Treatment of Major Depressive Disorder 9Ambry Genetics and SoftGenetics Form Exclusive Alliance for Extended Bioinformatics Support for Next Generation Sequencing Projects 2Ambry Genetics and SoftGenetics Form Exclusive Alliance for Extended Bioinformatics Support for Next Generation Sequencing Projects 3Echo Therapeutics and Handok Pharmaceuticals Sign South Korea License for Needle free Symphony 28TM 29 Transdermal Continuous Glucose Monitoring Syste 49185 1Echo Therapeutics and Handok Pharmaceuticals Sign South Korea License for Needle free Symphony 28TM 29 Transdermal Continuous Glucose Monitoring Syste 49185 2Echo Therapeutics and Handok Pharmaceuticals Sign South Korea License for Needle free Symphony 28TM 29 Transdermal Continuous Glucose Monitoring Syste 49185 3Echo Therapeutics and Handok Pharmaceuticals Sign South Korea License for Needle free Symphony 28TM 29 Transdermal Continuous Glucose Monitoring Syste 49185 4Unique Collaboration Between TB Alliance and Tibotec To Accelerate Tuberculosis Drug Development 49180 1Unique Collaboration Between TB Alliance and Tibotec To Accelerate Tuberculosis Drug Development 49180 2Unique Collaboration Between TB Alliance and Tibotec To Accelerate Tuberculosis Drug Development 49180 3Unique Collaboration Between TB Alliance and Tibotec To Accelerate Tuberculosis Drug Development 49180 4Unique Collaboration Between TB Alliance and Tibotec To Accelerate Tuberculosis Drug Development 49180 5Unique Collaboration Between TB Alliance and Tibotec To Accelerate Tuberculosis Drug Development 49180 67 Proven Steps 3A How to Defeat Stress Without Going Through the Embarrassment of Counseling 3A Proven Ways to Defeat Stress 49176 17 Proven Steps 3A How to Defeat Stress Without Going Through the Embarrassment of Counseling 3A Proven Ways to Defeat Stress 49176 27 Proven Steps 3A How to Defeat Stress Without Going Through the Embarrassment of Counseling 3A Proven Ways to Defeat Stress 49176 3
...in Previous Nonresponders also Reported, KENILWOR...SE: SGP ) today provided an update on the clinica...ational oral hepatitis C,protease inhibitor. Initi...ment-naive (previously untreated) hepatitis C pati... with PEGINTRON(TM) (peginterferon,alfa-2b) and RE...
...son Addresses Executives Before Day-Long ...17 Representatives from more than 50,Greater Wash...aster,preparedness specialists from Deloitte & Tou...f Greater Washington (Roundtable), the American Re...r for Disability Special,Needs and Preparedness, a...
Other Medicine Technology:Initial Results of Phase II Study with HCV Protease Inhibitor Boceprevir in Treatment-Naive Hepatitis C Patients Show a High Rate of Early Virologic Response 2Initial Results of Phase II Study with HCV Protease Inhibitor Boceprevir in Treatment-Naive Hepatitis C Patients Show a High Rate of Early Virologic Response 3Initial Results of Phase II Study with HCV Protease Inhibitor Boceprevir in Treatment-Naive Hepatitis C Patients Show a High Rate of Early Virologic Response 4Initial Results of Phase II Study with HCV Protease Inhibitor Boceprevir in Treatment-Naive Hepatitis C Patients Show a High Rate of Early Virologic Response 5Initial Results of Phase II Study with HCV Protease Inhibitor Boceprevir in Treatment-Naive Hepatitis C Patients Show a High Rate of Early Virologic Response 6Initial Results of Phase II Study with HCV Protease Inhibitor Boceprevir in Treatment-Naive Hepatitis C Patients Show a High Rate of Early Virologic Response 7Initial Results of Phase II Study with HCV Protease Inhibitor Boceprevir in Treatment-Naive Hepatitis C Patients Show a High Rate of Early Virologic Response 8Initial Results of Phase II Study with HCV Protease Inhibitor Boceprevir in Treatment-Naive Hepatitis C Patients Show a High Rate of Early Virologic Response 9Deloitte and Nonprofit Roundtable Host Real-World Disaster Exercise as Next Step in Developing Preparedness Plan for Greater Washington Region 2Deloitte and Nonprofit Roundtable Host Real-World Disaster Exercise as Next Step in Developing Preparedness Plan for Greater Washington Region 3Deloitte and Nonprofit Roundtable Host Real-World Disaster Exercise as Next Step in Developing Preparedness Plan for Greater Washington Region 4
BioLon
...isc is the right viscoelastic agent for the surgeo...extracap technique. Amvisc possesses sufficient vi...ens removal. Amvisc is highly cohesive so that com... quickly accomplished. Amvisc is priced to compete...
...lon GV is a sterile, non-pyrogenic, transparent vi...flammatory, high molecular weight (average = 5 mil...on GV contains 14 mg/mL of sodium hyaluronate 7000...sphate buffer (pH 7.0-7.5). This polymer consists ...
...lon is a sterile, nonpyrogenic, viscoelastic prepa... molecular weight fraction of sodium hyaluronate.,...te dissolved in physiological sodium chloride phos...ght polymer is made up of repeating disaccharide u...
Medicine Products: