Navigation Links
Repeated Liver Cell Proliferation, a Cause for Liver Cancer

mor cells," said Karin. Blocking JNK prevents liver injury but also inhibits liver regeneration, so the timing and context of activation are very important, he added.

"In this research, we set out to identify what causes inflammation in response to liver injury, as well as what stimulates the proliferation of surviving hepatocytes," said Karin. "Since we previously knew that JNK activity is required for normal liver cell proliferation, we wondered if the same activity is required for production of liver cancer in carcinogen-exposed mice. The results were clear JNK1 is critical for tumor development."

The scientists genetically removed JNK1 to test if its increased activation, caused by the absence of IKK?ò, was responsible for accelerated tumor development. When JNK1 was removed, the number and size of cancerous liver tumors decreased, and the tumors grew more slowly. Increased JNK1 activation was found in diseased liver and tumors when compared to normal tissue.

Hepatocellular carcinoma (HCC), the most common form of liver cancer, is the third leading cause of cancer deaths worldwide. Its major risk factors are persistent infection with hepatitis B and C viruses, and exposure to toxic chemicals, including alcohol ?V all of which cause chronic liver injury and inflammation. Although not common in the United States., the incidence of HCC is on an upward trajectory, with little hope for treatment or cure through chemotherapy, radiation or other traditional cancer treatments.

"We now understand development of liver cancer in mice. Since inflammation drives both damage and regeneration in liver tissue, it is the repeating cycle of damage, inflammation and regeneration that leads to liver cancer," said Karin. "However, this knowledge is not satisfactory until we find out if it applies to humans."

Source: Eurekaert
'"/>




Page: 1 2

Related medicine news :

1. New Findings for Repeated Miscarriages
2. Repeated checking causes memory distrust
3. Repeated Heart Surgery with Older Blood Transfusion Pack More Death Risk
4. Repeated Weight loss Messages Have No Effect On Couch Potatoes
5. Genes May Trigger Repeated Premature Birth In Blacks
6. Blood Cells Capable of Regenerating Liver
7. Liver donors can thrive after transplant
8. Heavy Drinking Raises Risk of Liver Cancer
9. Arthritis Drug May Cause Liver Damage
10. Liver transplant oversight urged
11. Liver key to extending life
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Repeated Liver Cell Proliferation Cause for Liver Cancer

(Date:7/29/2015)... ... July 29, 2015 , ... One of the world’s leading ... the potentially lifesaving impact of removing aluminum from Alzheimer’s disease patients, announced the ... is based on a successful pilot study published in The Journal of Alzheimer’s ...
(Date:7/29/2015)... ... , ... One may not expect to encounter a kickball game or the ... was happening on the campus of Piedmont Crossing , a local 60-acre retirement ... Only , a five-star childcare center which operates on the same campus. As many ...
(Date:7/28/2015)... (PRWEB) , ... July 29, 2015 , ... Talking About ... 18, 2015 — 1:30 p.m. – 3:00 p.m. EDT, http://www.fdanews.com/productpipeline , When ... can — and can’t — say about it is tightly regulated by the FDA. ...
(Date:7/28/2015)... ... July 29, 2015 , ... The insurance telematics or usage-based insurance (UBI) industry ... to access the on-board vehicle data and better understand customer behavior behind the wheel. ... vehicle data. However times are changing and automakers realize that with the Internet of ...
(Date:7/28/2015)... ... July 28, 2015 , ... A skin cancer screening program offered by the ... A award for “helping to make the world a better place.” , The Choose ... the American Society of Association Executives. Power of A recognizes organizations annually that “distinguish ...
Breaking Medicine News(10 mins):Health News:Children's Medical Safety Research Institute Announces Innovative Study on Alzheimer’s Treatment Is Subject of Crowd Funding Campaign 2Health News:Children's Medical Safety Research Institute Announces Innovative Study on Alzheimer’s Treatment Is Subject of Crowd Funding Campaign 3Health News:North Carolina Retirement Community Re-Launches Intergenerational Programming with Onsite Daycare Center 2Health News:North Carolina Retirement Community Re-Launches Intergenerational Programming with Onsite Daycare Center 3Health News:North Carolina Retirement Community Re-Launches Intergenerational Programming with Onsite Daycare Center 4Health News:FDAnews Announces — Talking About Your Product Pipeline: How FDA and SEC Regulate Life Sciences Communications Webinar, Aug. 19, 2015 2Health News:FDAnews Announces — Talking About Your Product Pipeline: How FDA and SEC Regulate Life Sciences Communications Webinar, Aug. 19, 2015 3Health News:FDAnews Announces — Talking About Your Product Pipeline: How FDA and SEC Regulate Life Sciences Communications Webinar, Aug. 19, 2015 4Health News:General Motors Engaging Insurance Partners for the Connected Car 2Health News:General Motors Engaging Insurance Partners for the Connected Car 3Health News:ASDS Skin Cancer Program Honored 2Health News:ASDS Skin Cancer Program Honored 3
... Stepped-up vaccination requirements, a boost in resources for prevention and ... that dispelled the stigma of HIV/AIDS are needed to curb ... says a new report from the Institute of Medicine. ... liver cancer, liver disease, and death each year -- taking ...
... ... Saturday and Sunday, January 16-17, 2010, 9 a.m. to 5 p.m. The mattress retailer will ... ... NBC-4 Health & Fitness Expo on Saturday and Sunday, January 16-17, 2010, 9 a.m. to ...
... , WASHINGTON, Jan. 11 ... nation, and the American Red Cross encourages everyone to get vaccinated ... (Logo: http://www.newscom.com/cgi-bin/prnh/20090108/RedCrossLOGO ) , National Influenza Vaccination Week, which ... how to prevent the spread of the flu and to encourage ...
... PHOENIX, Jan. 11 Dr. Leonard Kirschner has been appointed ... Jan. 1. He joins the other board members in providing ... longtime healthcare leader in Arizona, Dr. Kirschner brings extensive managed ... president of AARP Arizona and is a member of the ...
... National Salt Reduction Initiative, a New York City-led partnership of ... targets to guide a voluntary reduction of salt levels in ... limit of salt each day causing widespread high blood ... stroke in ways that they cannot control on their ...
... safe practices only about half the time, study finds, ... made for kids are getting better at portraying safety ... they,re still missing the mark about half the time. ... been tracking injury-prevention practices in movies since 1995. The ...
Cached Medicine News:Health News:IOM report recommends steps to tackle hepatitis B and C 2Health News:IOM report recommends steps to tackle hepatitis B and C 3Health News:Mattress Warehouse to Present at the NBC-4 Health & Fitness Expo in Washington, DC 2Health News:Don't Let the Flu Get to You: American Red Cross Encourages Everyone to Get Vaccinated During National Influenza Vaccination Week 2Health News:Don't Let the Flu Get to You: American Red Cross Encourages Everyone to Get Vaccinated During National Influenza Vaccination Week 3Health News:Dr. Leonard Kirschner Joins SCAN Health Plan Arizona Board of Directors 2Health News:Cities and states propose voluntary framework for cutting salt in packaged and restaurant foods 2Health News:Cities and states propose voluntary framework for cutting salt in packaged and restaurant foods 3Health News:Seat Belts, Bike Helmets Go Unused in Movies Aimed at Kids 2Health News:Seat Belts, Bike Helmets Go Unused in Movies Aimed at Kids 3
(Date:7/28/2015)...  Express Scripts Holding Company (Nasdaq: ESRX ) ... Scripts stockholders of $600.1 million, or $0.88 per diluted ... Table 4, were $1.44 for the second quarter. ... across healthcare are validating the need for size and ... "But, what matters most is how that size and ...
(Date:7/28/2015)... Calif. , July 28, 2015  Nevro ... device company that is providing innovative evidence-based solutions ... the publication of the SENZA-RCT results in the ... Journal of the American Society of Anesthesiologists. ... ground-breaking study that was the first to directly ...
(Date:7/28/2015)... CHICAGO , July 28, 2015 The ... a patient safety fundraising campaign, " Surviving Your Hospital ... receiving the care they deserve! None of these patients ... JD (Founder and Executive Director, PPAHS) referring to the ... of the National Coalition to Promote Continuous Monitoring ...
Breaking Medicine Technology:Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 2Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 3Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 4Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 5Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 6Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 7Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 8Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 9Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 10Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 11Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 12Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 13Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 14Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 15Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 16Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 17Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 18Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 19Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 20Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 21Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 22Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 23Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 24Express Scripts Announces 2nd Quarter Results; Increases 2015 Guidance Range 25Nevro Announces Publication of SENZA-RCT Results in Anesthesiology 2Surviving Your Hospital Stay: Physician-Patient Alliance for Health & Safety Launches Fundraising for Patient Safety 2
... Oct 24 /PRNewswire-Asia-FirstCall/ -- Sinovac Biotech Ltd. (Nasdaq: ... in China, announced today that Sinovac Biotech (Hong Kong) ... has received the Certificate of Drug/Product Registration from the ... vaccine Anflu®. Sinovac filed the application with the Hong ...
... Inc. (Nasdaq: CEPH ) today announced that ... NUVIGIL® (armodafinil) Tablets [C-IV] and PROVIGIL® (modafinil) Tablets [C-IV] ... Administration (FDA).  Both the NUVIGIL and PROVIGIL REMS consist ... potential risks associated with the use of these medications, ...
Cached Medicine Technology:Sinovac Receives Drug Registration Certificate from Hong Kong Department of Health for Seasonal Flu Vaccine Anflu(R) 2Cephalon Announces FDA Approval of Risk Evaluation and Mitigation Strategies for NUVIGIL and PROVIGIL 2Cephalon Announces FDA Approval of Risk Evaluation and Mitigation Strategies for NUVIGIL and PROVIGIL 3Cephalon Announces FDA Approval of Risk Evaluation and Mitigation Strategies for NUVIGIL and PROVIGIL 4
... Add the perfect mix of powerful, ... practice, with the Palomar StarLux® Pulsed Light ... handpieces to one compact base unit ... systems for different treatments., You can choose ...
Perfect for physicians who prefer a Heavier and Longer tubing, permitting them maximum access around the OR table. 12 feet in length Sizes availabe to fit any vacuum canisters...
... The Klein Pump provides ... requiring tumescent infiltration. Operates on ... off switch with safety Interlock ... Single Spike Tubing, Double Spike ...
Inquire...
Medicine Products: