( According to researchers at the Univers...)Repeated Liver Cell Proliferation, a Cause for Liver Cancer,Health

According to researchers at the University of California, San Diego (UCSD) School of Medicine, liver cancer can possibly be caused by cycles of liver cell// death and renewal – liver cell proliferation.

The research, appearing online the week of June 19 in advance of publication in the journal Proceedings of the National Academy of Sciences, underscores the importance of JNK1-mediated cell death and compensatory proliferation. The findings by Michael Karin, Ph.D., professor pharmacology in UCSD?|s Laboratory of Gene Regulation and Signal Transduction, and colleagues strongly suggest that the control of tissue renewal through the IKK and JNK pathways plays a key role in liver cancer in mouse models.

One link between inflammation and cancer is known to involve the NF-kB pathway, which regulates gene expression. In research published in the journal Cell in 2005, Karin and his colleagues at UCSD implicated the pathway's activator, IKK , in chemically induced liver cancer. However, the surprising outcome of those studies was the finding that while NF-??B activation in hepatocytes (liver cells) prevents liver cancer, its activation in inflammatory cells, such as tissue macrophages, promotes tumor development.

In their latest work, the research team studied what precedes inflammation ?V the injury of hepatocytes caused by toxic chemicals, which sets in motion the inflammation process.

Their research showed that the absence of IKK?ò in hepatocytes led to increased c-Jun N-terminal kinase (JNK) activation after exposure to a chemical carcinogen used to elicit liver cancer in mice. Importantly, deletion of the gene that codes for the major isoform of JNK in liver cells, JNK1, prevented the development of liver cancer and reversed the tumor-enhancing effect caused by ablation of IKK?ò.

"We found that long-term JNK activation leads to cell death; if activated briefly, it stimulates proliferation of pre-malignant and cancerous tu
'"/>




Page: 1 2
Related medicine news :

1. New Findings for Repeated Miscarriages
2. Repeated checking causes memory distrust
3. Repeated Heart Surgery with Older Blood Transfusion Pack More Death Risk
4. Repeated Weight loss Messages Have No Effect On Couch Potatoes
5. Genes May Trigger Repeated Premature Birth In Blacks
6. Blood Cells Capable of Regenerating Liver
7. Liver donors can thrive after transplant
8. Heavy Drinking Raises Risk of Liver Cancer
9. Arthritis Drug May Cause Liver Damage
10. Liver transplant oversight urged
11. Liver key to extending life