Navigation Links
Renegade RNA: Clues to Cancer and Normal Growth

Researchers at Johns Hopkins have discovered that a tiny piece of genetic code apparently goes where no bit of it has gone //before, and it gets there under its own internal code.

MicroRNAs, already implicated in cancer and normal development, latch on to and gum up larger strands of RNA that carry instructions for making the proteins that do all the cell’s work. They are, says Joshua Mendell, M.D., Ph.D., an assistant professor in the McKusick-Nathans Institute of Genetic Medicine at Hopkins, like “molecular rheostats that fine-tune how much protein is being made from each gene.”

That’s why normally microRNAs always have appeared to stick close to the cell’s protein-making machinery.

But during a survey of more than 200 of the 500 known microRNAs found in human cells, Mendell’s team discovered one lone microRNA “miles away” --- in cellular terms --- from all the others.

“It was so clearly in the wrong place at the wrong time for what we thought it was supposed to be doing that we just had to figure out why,” says Hun-Way Hwang, a graduate student in human genetics and contributor to the study.

Consisting of only 20 to 25 nucleotide building blocks (compared to other types of RNA that can be thousands of nucleotides long), each microRNA has a different combination of blocks. Mendell’s team realized that six building blocks at the end of the wayward miR-29b microRNA were noticeably different from the ends of other microRNAs.

Suspicious that the six-block end might have something to do with miR-29b’s location, the researchers chopped them off and stuck them on the end of another microRNA. When put into cells, the new microRNA behaved just like miR-29b, wandering far away from the cell’s protein-making machinery and into the nucleus, where the cell’s genetic material is kept.

The researchers then stuck the same six-block end onto another type of small RNA, a small-interfering RNA or siRNA t
'"/>




Page: 1 2

Related medicine news :

1. Innovative yeast genome may handle Cancer Clues
2. Researchers Discover New Clues To Identify Tooth Decay
3. Leeches Provide Clues Regarding The Prevention Of Heart Disease
4. Excavations Reveal Clues Of Early Warfare
5. Sleeping Computers Yield Clues About Genetic Disorders
6. Clues To Identify Psychological Seizures
7. A Human Brain Gene Could Hold Clues On The Evolution Of Brain Capacity
8. Clues to the Mystery of Lou Gehrigs Disease
9. Clues Found On How Deadly Bacterium Gains Foothold
10. Clues to Allay Aging
11. Regrowth of Zebrafishs Tail Fin may Offer Clues for Treating Human Injuries
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Renegade RNA Clues Cancer and Normal Growth

(Date:9/2/2015)... ... ... an article published August 12 by International Business Times, a new bill was ... juries in cases meant to decide if a police officer used deadly or excessive force ... Ferguson and New York City that absolved police officers of charges in the deaths of ...
(Date:9/2/2015)... ... , ... Date and time: Oct. 3, 2015, 9 a.m. to 4 p.m. ... Bryn Athyn, Pa 19009 , Cost: $50 per person; includes lunch , The Quakertown, ... author Sam Keen based on his new book which he co-authored with his son, ...
(Date:9/2/2015)... ... September 02, 2015 , ... ... announces its latest addition to its screen mirroring and extending product line -- ... Wireless Display, which operates in local WIFI setting, the new Splashtop Wired XDisplay ...
(Date:9/2/2015)... ... September 02, 2015 , ... Michael Elliot Media announces ... a plus-size actress as the primary love interest in the film. The campaign is ... film, significantly affects how and what we think,” Michael Elliot, an award-winning screenwriter and ...
(Date:9/2/2015)... (PRWEB) , ... September 02, 2015 , ... Ericson is ... CDI Education Director for HCPro and Associate Director of Education for the Association for ... Advancing CDI and ICD-10 for CDI Boot Camps. She serves as a CDI subject ...
Breaking Medicine News(10 mins):Health News:Article on Recent Grand Jury Law Brings Increased Accountability to Wrongful Death Cases, says the Law Offices of Burg & Brock 2Health News:Article on Recent Grand Jury Law Brings Increased Accountability to Wrongful Death Cases, says the Law Offices of Burg & Brock 3Health News:justCommunity, Inc. and Bryn Athyn Men’s Groups Present Workshop on Family Reconciliation 2Health News:Splashtop Launches Wired XDisplay, the Fastest Screen Sharing Solution for Extending and Mirroring Your Computer Screen to Mobile Devices 2Health News:Splashtop Launches Wired XDisplay, the Fastest Screen Sharing Solution for Extending and Mirroring Your Computer Screen to Mobile Devices 3Health News:Award-Winning Screenwriter Uses Crowdfunding Campaign to Change Hollywood’s Ideal of Beauty to Include PLUS-SIZE Women 2Health News:ezDI Names Noted CDI Educator Cheryl Ericson as Company’s Clinical Documentation Manager 2Health News:ezDI Names Noted CDI Educator Cheryl Ericson as Company’s Clinical Documentation Manager 3Health News:ezDI Names Noted CDI Educator Cheryl Ericson as Company’s Clinical Documentation Manager 4
... Exercise is known to have a positive effect on maintaining ... of the Journal of Thoracic Oncology has shown ... and secondary prevention of cancer. The Journal of Thoracic ... for the Study of Lung Cancer. Dr. Jennifer Temel at ...
... for All Michigan Residents Will ... recession sends record numbers of Michigan residents onto the ... health insurance, any mid-year cuts to Medicaid would harm ... hospital executives, long-term-care and mental health providers implored the ...
... Media Plays Major Role in Prompting Parent-Teen Discussions ... Dads Have Opportunity to Engage More with KidsNEW ... survey of parents, attitudes about teen drug and ... Partnership for a Drug-Free America and MetLife Foundation. ...
... -- Dr. Hisao Asamura and his team of researchers at ... records of 2,281 patients who underwent lung cancer resection surgery ... May issue of the Journal of Thoracic Oncology , ... of Lung Cancer. Dr. Asamura and his team found that ...
... NASHVILLE, Tenn., May 4 Healthcare Management Systems, Inc.(R) ... as a hospital information technology provider. HMS has ... top HIT vendors; they currently develop, sell and support ... Over the last decade, HMS has expanded its ...
... A new study on old rats by a Penn State ... heart disease and aging in women. , Heart disease is ... of 75. After menopause, women lose their ability to produce ... somehow make women more vulnerable to heart disease and heart ...
Cached Medicine News:Health News:EO Medicaid Cuts Would Harm People 2Health News:EO Medicaid Cuts Would Harm People 3Health News:National Survey: Parents Report Increased Awareness of Risks of Teen Prescription Drug Abuse, But Preventative Action Lags 2Health News:National Survey: Parents Report Increased Awareness of Risks of Teen Prescription Drug Abuse, But Preventative Action Lags 3Health News:National Survey: Parents Report Increased Awareness of Risks of Teen Prescription Drug Abuse, But Preventative Action Lags 4Health News:National Survey: Parents Report Increased Awareness of Risks of Teen Prescription Drug Abuse, But Preventative Action Lags 5Health News:Healthcare Management Systems Celebrates 25 Years 2Health News:Penn State professor investigates estrogen, heart disease connection in women 2
(Date:9/2/2015)... Sept. 2, 2015 Research and Markets ( http://www.researchandmarkets.com/research/l8z67c/pharmaceutical ... Affairs in China (Basel, Switzerland - November 26-27, 2015)" ... provide a detailed overview of the key areas of pharmaceutical ... Hong Kong , Macau and ... - All important aspects of gaining and maintaining a ...
(Date:9/2/2015)... Miss. , Sept. 2, 2015   Gulf Coast Tattoo ... removal services with the cutting-edge Astanza Duality laser in ... unwanted ink erase their tattoo regret and take back control of ... but extends its services to Biloxi ... region. "With tattoo regret being as prevalent as it ...
(Date:9/2/2015)... 2015  Research and Markets ( http://www.researchandmarkets.com/research/rf2c5p/an_introduction ) ... Introduction to the Medical Devices Directive (London, UK ... offering. This seminar provides a ... It will explain the Directives and which products ... to choose one and outline what a manufacturer ...
Breaking Medicine Technology:Pharmaceutical Regulatory Affairs in China Seminar: Basel, Switzerland - November 26-27, 2015 2Gulf Coast Tattoo Removal Delivers Unrivaled Tattoo Removal Results To Biloxi And Gulfport With Astanza Duality 2
... Accurately tests for Nystagmus when ... 10" high by 8" diameter. Light ... ball bearings for effortless spin mechanism. ... from patient. Includes both Adult and ...
Diagnose dry eye, assess the effectiveness of permanent punctal occlusion, collagen - dissolvable in 3-5 days, all are 2 mm long. Sterile...
Clear Base Stand Magnifiers are ideal for any visual task that requires high magnification....
Contour design eyelid implants....
Medicine Products: