Navigation Links
Regeneration of muscle

Skeletal muscle has a remarkable capacity to regenerate following exercise or injury and harbors two different types of adult stem cells to accomplish the job: satellite cells and adult stem cells // that can be isolated as side population (SP) cells. A certain group of these stem cells is involved in muscle tissue repair, but is only triggered into the muscle cell development pathway by injury.

In previous studies, researchers have demonstrated that Pax7 is required to turn adult stem cells into muscle cells during regeneration. Here, the researchers worked with mouse models and in vitro experiments to investigate whether Pax7 is sufficient to initiate muscle cell formation in injured tissue.

It was seen that stem cells taken from regenerating muscle in mice lacking the Pax7 gene could not become muscle cells, and that by putting Pax7 back into stem cells taken from uninjured muscle, they can generate a population of cells that readily differentiate into muscle cells.

When stem cells engineered to express Pax7 proteins were injected into the muscles of mice lacking dystrophin (the protein defective in muscular dystrophy), the cells differentiated, forming dystrophin-expressing muscle cells in the defective muscle. Researchers say this shows that engineered "donor cells" can differentiate in living tissue and help repair damaged muscle of recipient mice. When the researchers injected Pax7 (using a gene therapy virus) into the damaged muscle of mice lacking Pax7, they observed the production of muscle-forming cells that not only gave rise to differentiated muscle cells, but also aided in tissue repair.

Thus, researchers argue that these results establish Pax7 as a key regulator of muscle cell differentiation in specific populations of adult stem cells during muscle tissue regeneration in mice. If therapeutic strategies that activate Pax7 in adult stem cells can turn them into muscle cells, effectively replenishing injured or dis eased muscle tissue, there's hope of reversing the debilitating effects of progressive muscle-wasting diseases.

Researchers say the results on these mouse adult stem cells are encouraging however they say the usefulness of such an approach in humans will require intensive investigation.
'"/>




Related medicine news :

1. Limb Regeneration In Humans: A Future Possibility
2. Research Throws Light On Regeneration of Hearing Cells
3. Oncomodulin- Path To Nerve Regeneration
4. Growth Factor Aids in Regeneration of Heart Blood Vessel
5. Regeneration After Spinal Cord Injury
6. Rescuing Injured Hearts by Enhancing Regeneration
7. Limb Regeneration Exists Innately In All Vertebrates – Says Researc
8. Vanderbilt Performs States First Stem Cell Heart Regeneration Therapy
9. UF Launches Project to Bridge the Regeneration Gap
10. Liver Regeneration may Be Simpler Than Previously Thought
11. Liver Regeneration Unplugged
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/9/2016)... ... December 09, 2016 , ... MEDI+SIGN®, a provider of ... a new solution for Emergency Departments (ED) has been added to their portfolio. ... Department examination rooms, and with a simplified pallet of information available to the ...
(Date:12/8/2016)... ... December 08, 2016 , ... The West Virginia Medical Institute ... The name change aligns the entire company with its existing Quality Insights ... , “We are very proud of the achievements associated with the West Virginia ...
(Date:12/8/2016)... ... December 08, 2016 , ... Russ DiGilio , ... first national #QuackGivesBack campaign which supported local breast cancer organizations during National Breast ... Quack Gives Back initiative, and we’re very pleased with the participation in ...
(Date:12/8/2016)... , ... December 08, 2016 , ... ... offering Medication Therapy Management (MTM), adherence, and other pharmacist-delivered patient care services, has ... general counsel and Eric Hoessel to vice president of sales. , Litsinger ...
(Date:12/8/2016)... , ... December 08, 2016 , ... David J. ... global law firm Greenberg Traurig, LLP, will speak at DeviceTalks West, Dec. 12, 2016, ... the DeviceTalks series, and attorneys from the firm’s global Life Sciences & Medical Technology ...
Breaking Medicine News(10 mins):
(Date:12/9/2016)... Texas , Dec. 9, 2016  RxWiki Inc., ... apps, and digital marketing strategies of thousands of pharmacies ... it won Austin Inno,s "50 on Fire" ... "We,re pleased to accept the award as ... Loughlin , Chief Executive Officer at RxWiki. "Our platform ...
(Date:12/9/2016)... Dec. 9, 2016  Forge Therapeutics, Inc. today ... Stock Exchange: EVT, TecDAX, ISIN: DE0005664809) to advance ... the treatment of bacterial infections including those caused ... as an attractive antibacterial target for more than ... suitable chemical starting points has hampered its progress. ...
(Date:12/8/2016)... NEW YORK , Dec. 8, 2016 ... ... such as reducing loss of blood during surgeries, lowering the ... surgeries, and decreasing risks of SSIs. The patient warming systems ... and intravascular warming systems.These benefits in turn reduce the stay ...
Breaking Medicine Technology: