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Recurrent Gliomas: Vorinostat Shows Anti-cancer Activity

with the target pathways. Dr. Galanis says the researchers plan to expand this analysis to all study patients. This will help define a patient population that has a higher likelihood of benefiting from treatment -- allowing treatment individualization in the future.

Vorinostat is the first FDA approved oral anti-cancer agent that inhibits an enzyme, histone deacetylase, that is closely associated with DNA in cells. By inhibiting the deacetylation of histones -- proteins that help organize the structure of DNA -- vorinostat alters the expression of several important genes and proteins resulting in tumor cell death and stopping tumor growth.

Dr. Galanis says that study findings indicate that vorinostat by itself shows anti-cancer activity in glioblastoma multiforme. Plans are ongoing to combine vorinostat with other drugs in future clinical trials for brain tumor patients.


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