Navigation Links
Recurrent Gliomas: Vorinostat Shows Anti-cancer Activity

CHICAGO Findings presented today at the American Society of Clinical Oncology Annual Meeting by Eva Galanis, M.D., a Mayo Clinic oncologist, reveals that a novel application of the drug vorinostat shows activity in patients with recurrent glioblastoma multiforme. The study was conducted by North Central Cancer Treatment Group (NCCTG) researchers, based at Mayo Clinic in Rochester, Minn. Eva is the lead investigator of the study.

Glioblastoma multiforme is a lethal primary brain tumor. The average survival of glioblastoma patients is 12-16 months. These tumors spread quickly to other parts of the brain, and because of this are difficult to treat and often recur. When the tumor recurs, treatment options are limited, and patients survive for an average of three to four months.

"Existing treatment interventions have minimal impact on the outcome of recurrent glioblastoma multiforme patients," Dr. Galanis says. "Using vorinostat to treat glioblastoma multiforme patients who have relapsed following surgery, radiation and chemotherapy, we found that 15 percent of the patients had no tumor recurrence for six months or longer following treatment initiation. The median overall survival of the patients enrolled on the trial was 5.7 months -- similar patient populations enrolled in prior NCCTG trials had a median overall survival of between 4 and 4.4 months."

This study was the first application of vorinostat in targeting brain cancer. Vorinostat is approved by the U.S. Food and Drug Administration (FDA) for the treatment of cutaneous T cell lymphoma in patients who have failed two or more systemic therapies.

An additional group of patients in this study was treated with vorinostat prior to surgery, and a gene and protein analysis of their resected tumors was performed. This analysis confirmed increase in histone acetylation and showed gene changes indicating that vorinostat reaches the glioblastoma tumors and interferes with the target pathways. Dr. Galanis says the researchers plan to expand this analysis to all study patients. This will help define a patient population that has a higher likelihood of benefiting from treatment -- allowing treatment individualization in the future.

Vorinostat is the first FDA approved oral anti-cancer agent that inhibits an enzyme, histone deacetylase, that is closely associated with DNA in cells. By inhibiting the deacetylation of histones -- proteins that help organize the structure of DNA -- vorinostat alters the expression of several important genes and proteins resulting in tumor cell death and stopping tumor growth.

Dr. Galanis says that study findings indicate that vorinostat by itself shows anti-cancer activity in glioblastoma multiforme. Plans are ongoing to combine vorinostat with other drugs in future clinical trials for brain tumor patients.


Related medicine news :

1. Estrogen Does Not Prevent Recurrent Strokes
2. Radiation Therapy An Effective Solution For Recurrent Prostate Cancer
3. Prevention Of Recurrent Leg Ulcers
4. Measuring Urinary Protein Helps In Detecting Recurrent Bladder Cancer
5. Sertraline Can Prevent Recurrent Depressive Episodes In Diabetics
6. Angola Warned of Recurrent Cholera Outbreaks
7. Gemzar the New Drug for Recurrent Ovarian Cancer
8. Recurrent Stroke Risk is Minimized by Statin
9. Blood Markers Predict Risk for Recurrent Stroke and Mortality
10. Targeted Compound Helps Recurrent Prostate Cancer Patients
11. Ancient Indian Herb May Prove Cure For Recurrent UTI
Post Your Comments:

(Date:11/30/2015)... , ... November 30, 2015 , ... ... only four states in the U.S. require dental technicians to be certified or ... dental industry, NADL created the “What’s In Your Mouth?” campaign to inform dentists ...
(Date:11/30/2015)... ... November 30, 2015 , ... MOSI recently added two ... along with Back to the Jurassic to their collection of interactive exhibits within the ... dynamic worlds that will allow guests to get closer than ever to a range ...
(Date:11/30/2015)... ... 2015 , ... In an effort to provide local families ... Christian Church of Flint, MI, hosted a family-oriented evening themed on “Candy Land”, ... candy dubbed “Candy Mountain”. , A Forever Recovery, a holistic treatment center for ...
(Date:11/30/2015)... ... November 30, 2015 , ... The presidential race normally deals with political issues ... it a national news story when Donald Trump makes disparaging remarks about Hillary Clinton’s ... more than anyone wants to admit when it comes to how people are viewed ...
(Date:11/30/2015)... ... November 30, 2015 , ... Rick Sommer, president of Intellitec ... Management of Information Systems course. Based in Wilmington Delaware, Intellitec Solutions is an ... before student in the Enterprise Resource Planning (ERP) Systems class. The course focuses ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... décembre 2015 MEDTEC Japon ... conférence d,Asie portant sur la conception ... manufacturière, se tiendra à ... 22 avril 2016. ... Photo - Logo ...
(Date:11/30/2015)... -- Nevro Corp. (NYSE: NVRO ), a global medical ... treatment of chronic pain, today announced that the Patent Trial ... Office (USPTO) has denied instituting an inter partes ... --> --> On ... two petitions challenging the validity of certain claims of the ...
(Date:11/30/2015)... 2015 Next week, December 2-3, BIOMEDevice ... ) co-located events covering the latest in Medtech innovation, ... will draw more than 3,000 design industry professionals to ... The events, combined show floor will host more than ... --> --> BIOMEDevice features suppliers ...
Breaking Medicine Technology: